Epilepsy MERFISH Report

1. Overview

  • Project: Epilepsy MERFISH Analysis

1.1 Sample Information

A brief sample information is generated from the submission table for the following analysis.

Sample Index and Basic Information
Expt Case CHOC_Path_ID Sample_Index Sample_Region Sex Age Age_Group Genotype Diagnosis Gene.Panel Region DataPath Comment
1 1300 SP24-1300-1A 1300_A7 Left frontal tuber female 10 year Junior Epilepsy tuberous sclerosis 500 region_0 Y:_Imaging_data_2\202409191416_20240919Ivy1300A7B12H500ADBCP1407x02_VMSC05201 Exclude because not enough cells contained
1 1300 SP24-1300-1B 1300_B11 Left frontal tuber female 10 year Junior Epilepsy tuberous sclerosis 500 region_1 Y:_Imaging_data_2\202409191416_20240919Ivy1300A7B12H500ADBCP1407x02_VMSC05201 NA
2 4_12112023 SP24-1463-1A 1463_TLE Temporal Lobe female 6 month Junior Epilepsy focal cortical dysplasia IIa 500 region_0 Y:_Imaging_data_2\202409191416_20240919Ivy41211H500ADBCP1407x01_VMSC00101 NA
2 4_12112023 SP24-1463-1A 1463_TLE_dup Temporal Lobe female 6 month Junior Epilepsy focal cortical dysplasia IIa 500 region_1 Y:_Imaging_data_2\202409191416_20240919Ivy41211H500ADBCP1407x01_VMSC00101 NA
3 NS02 NA NS02_FLE Frontal Lobe female 29 year Adult Epilepsy Frontal lobe epilepsy 300 region_0 Z:_Imaging_data_17_DATA_202202141032_20220214-NS02Ctx300VZG172_VMSC00101 NA
4 NS01 NA NS01_TLE Temporal Lobe female 50 year Adult Epilepsy MTS 300 region_0 Z:_Imaging_data\202112261340_122621Lobotomy01-Ctx-frzn-300GPM_VMSC00101 NA

1.2 Sample Section Information

Junior Epilepsy Sample Collection

Junior Epilepsy Sample Collection

Adult Epilepsy Sample Collection

Adult Epilepsy Sample Collection

1.3 Sample Slice Pictures

NS01 Slice Experiment Note

NS01 Slice Experiment Note

NS02 Slice Experiment Note

NS02 Slice Experiment Note

2. Data Quality Control

2.1 MERSCOPE Quality Summary

The summaries present the data quality assessment automatically generated by MERSCOPE for each experiment. We mainly focus on the transcripts level for each sample. So we’re looking for high density in transcripts, based on the transcripts count per field of view (FOV), transcript density in FOV, and frequency of transcripts detected.

Generally, log10 transcript count > 4.0 in most area can be considered as a good quality standard.

Need to note that the low accuracy in DAPI cell boundary is not a concern, as a self-designed cell segmentation processing will take over this task.

2.1.1 (Bad Quality!) 1300_A7

2.1.2 1300_B11

2.1.3 1463_TLE

2.1.4 1463_TLE_dup

2.1.5 NS02_FLE

2.1.6 NS01_TLE

2.2 Bad Sample: Low Cell Count Captured

Cell Detection Comapre on Bad Sample

Cell Detection Comapre on Bad Sample

3. Data Processing & Analysis

3.1 Cell Segmentation & Filtering

Based on the spatial information and images obtained from MERFISH, we developed a machine learning model using the Cellpose algorithm to distinguish individual cells via MERFISH DAPI images.

To ensure the data quality and accuracy of cells, we have defined the minimum and maximum values for cell volume and gene count per cell. The cell volume should be between [100, 2500], and the gene count per cell > 25. After filter the outliers, the qualified cells count is shown in the following table.

Outliers were filtered from the data, and the qualified cell count is presented below. The transcript count Violin and transcript count Spatial Map are displayed here as part of the quality control reveal.

3.1.1 Cell Count after Filtering

Cell Total Count After Filtering
Sample Index Cell Count
X1300_B11 22938
X41211_TLE 36727
X41211_TLE_dup 31720
NS01_TLE 57074
NS02_TLE 51179

3.1.2 Transcript Count Violin

Transcript Count Violin After Filtering

Transcript Count Violin After Filtering

3.1.3 Transcript Count Spatial Map

Transcript Count Spatial Map After Filtering

Transcript Count Spatial Map After Filtering

3.2 Batch Effect & Dimension Reduction

We use Scanpy for the analysis of single-cell level transcriptome data. The initial stage of our analysis involves the elimination of batch effects, thereby ensuring that different samples from various batches are distributed within the same domain and are statistically reasonable to be integrated and compared. To achieve this, we utilize the Harmony algorithm.

Subsequently, we present visualizations of the batch difference by Leiden UMAP clusters. Also, we illustrate the distributions of the Leiden clusters for future analysis.

Umap of all samples combined cells

Umap of all samples combined cells

Umap of cells and colored by batch

Umap of cells and colored by batch

4. Cell Annotation

We use a recent published tool: Map My Cell and selected marker genes to perform cell type annotations for each cell. The annotation is based on adult human brain database.

With the annotation, we can identify and plot the selected types of cells in each sample.

4.1 Cell Type Umap

Cells are annotated from low resolution to high resolution as follows:

4.2 Cell Type Spatial Map

4.3 Glutamatergic-only Spatial Map

4.3 Non-Neuron Spatial Map

4.4 Cell Type Count Table

Cell Type Count
cell_type_new X1300_B11 X41211_TLE X41211_TLE_dup NS01_TLE NS02_TLE Total
Astrocyte 3391 3915 3548 7519 5677 24050
Endothelial 1315 1909 1692 4553 2795 12264
Microglia 2871 3697 3135 5323 5581 20607
OPC 1392 1846 1642 3837 8666 17383
Oligo 7380 15486 13732 14265 12096 62959
VLMC 718 980 857 2663 2344 7562
L2/3/4 IT 979 2022 1703 5854 3509 14067
L5/6 IT 2235 3663 2790 6395 4336 19419
L5/6 NP 153 278 149 287 177 1044
L6b 846 573 517 507 387 2830
Lamp5 195 290 235 682 599 2001
Pvalb 402 552 466 1334 1092 3846
Sst 713 868 742 1717 1294 5334
Vip 348 648 512 2138 2626 6272
Total 22938 36727 31720 57074 51179 199638

5. Epilepsy Gene Selection

5.1 Reference

From literal search, we located a list of epilepsy-related gene. Within this recent published paper: Integrative analysis of epilepsy-associated genes reveals expression-phenotype correlations, they cross-referenced multiple public dataset (including publich database OMIM and two recent studies by Macnee et al and Oliver et al), and then category the epilepsy-related genes into three different groups:

CEG: core-epilepsy gene, where seizures are the dominant phenotype

DEEG: developmental and epileptic encephalopathy gene, that are associated with developmental and epileptic encephalopathy.

SRG: seizure-related gene, which are characterized by the presence of seizures and gross brain malformations.

Epilepsy Genes within MERFISH Gene Panel
Gene Group_OMIM Group_Oliver
SYN1 CEG Focal, DEE
GRIN2A CEG Focal, DEE, MCD
KCNC1 CEG DEE, PME
HCN1 CEG & DEEG GGE, DEE
RELN CEG Focal, MCD
RORB CEG GGE, DEE
GRIN1 DEEG & SRG DEE, MCD
GRIN2B DEEG & SRG DEE, MCD
NTRK2 DEEG DEE
CPLX1 DEEG DEE
CUX2 DEEG GGE, DEE
GAD1 DEEG DEE
GRIA4 SRG DEE

6. Gene differentiation expresssion (Junior Epilepsy v.s. Adult Epilepsy)

Here, we use Pseudobulk to compute gene differential expression (DE). P value are adjusted using Benjamini–Hochberg procedure. The statistical significance was cut-off by log2(Fold Change) > 1 or log2(Fold Change) < -1 and p_value < 0.05.

The result are visualized via Volcano plot: a type of scatterplot that shows statistical significance (P value) versus magnitude of change (fold change).

The comparison is between Junior Epilepsy and Adult Epilepsy samples. A positive fold change means higher expression in the Junior Epilepsy group.

6.1 all

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 17109.6023 6.058502 0.4967209 12.196993 0.0000000 0.0000000
GRIA4 15782.3513 5.815645 0.2056857 28.274433 0.0000000 0.0000000
CHODL 14639.5845 5.596199 1.2570297 4.451923 0.0000085 0.0000327
GRM5 8919.3801 5.349343 0.2023444 26.436823 0.0000000 0.0000000
GPHN 7470.1533 4.842121 0.2199321 22.016440 0.0000000 0.0000000
SCTR 2697.6004 4.784964 0.6321602 7.569226 0.0000000 0.0000000
DLG4 24747.9825 4.302214 0.2593342 16.589460 0.0000000 0.0000000
CXCL10 4325.0420 4.214883 1.0448478 4.033969 0.0000548 0.0001866
SIM1 3348.3003 4.071995 1.0612040 3.837146 0.0001245 0.0003838
NOS3 4991.6027 3.621857 0.4074298 8.889525 0.0000000 0.0000000
RIMS1 9901.6993 3.321792 0.3171455 10.474031 0.0000000 0.0000000
MKI67 3702.6292 3.286472 1.0160152 3.234668 0.0012178 0.0030293
CREBBP 33853.3785 -3.112338 0.2578415 -12.070739 0.0000000 0.0000000
NR5A1 2038.5487 3.096564 0.3330988 9.296233 0.0000000 0.0000000
FLT1 6526.9568 3.089490 0.3139040 9.842149 0.0000000 0.0000000
PTEN 3400.9610 3.070543 0.4789985 6.410339 0.0000000 0.0000000
SNCA 16427.6211 3.034861 0.2810896 10.796777 0.0000000 0.0000000
CTSS 1168.6189 2.880994 0.2310513 12.469064 0.0000000 0.0000000
GAD2 5203.8532 2.869569 0.3238998 8.859435 0.0000000 0.0000000
P2RY12 4066.4935 2.817710 0.4621991 6.096313 0.0000000 0.0000000
DCN 5704.7830 2.674465 0.3427524 7.802909 0.0000000 0.0000000
TLX3 1777.4211 -2.566114 0.4929845 -5.205263 0.0000002 0.0000010
MEIS2 6077.8481 2.564418 0.2426044 10.570370 0.0000000 0.0000000
MAPK1 18880.2409 2.411323 0.2948895 8.177040 0.0000000 0.0000000
TACR2 919.1629 2.341556 0.3339996 7.010654 0.0000000 0.0000000
GRIN3B 1360.3547 2.309626 0.3849048 6.000511 0.0000000 0.0000000
NPY1R 3770.9522 2.226018 0.4471097 4.978683 0.0000006 0.0000031
NEGR1 8892.0999 2.175917 0.3207339 6.784182 0.0000000 0.0000000
SYT6 6799.6499 -2.152440 0.3760339 -5.724058 0.0000000 0.0000001
RELN 1331.2747 2.116777 0.2682924 7.889813 0.0000000 0.0000000
CX3CL1 20220.6923 -2.083974 0.2134867 -9.761611 0.0000000 0.0000000
NRG3 6729.4807 2.072832 0.2721787 7.615702 0.0000000 0.0000000
IGF1 1526.6643 2.045955 0.2902614 7.048663 0.0000000 0.0000000
NR2F2 5553.9270 1.964020 0.3471202 5.658038 0.0000000 0.0000001
KCNQ1 3516.4355 -1.943907 0.3678687 -5.284240 0.0000001 0.0000007
RIMS2 7725.5260 1.923782 0.2309806 8.328763 0.0000000 0.0000000
FEZF2 9562.0059 -1.799563 0.2242161 -8.026020 0.0000000 0.0000000
TAC1 2082.6850 1.773969 0.2702942 6.563105 0.0000000 0.0000000
ROS1 1958.9448 1.754657 0.2689879 6.523180 0.0000000 0.0000000
PCP4 1261.3991 1.746375 0.3870129 4.512447 0.0000064 0.0000253
CA12 1371.2461 -1.727721 0.4478359 -3.857933 0.0001143 0.0003634
MAP4K3 8547.5531 1.724050 0.1758685 9.803062 0.0000000 0.0000000
KCTD4 1329.0205 1.674541 0.4518321 3.706113 0.0002105 0.0006108
SLC32A1 11042.6906 1.664773 0.2829494 5.883644 0.0000000 0.0000000
CRH 3253.2816 1.664136 0.3018486 5.513149 0.0000000 0.0000002
AGTR1 501.6256 1.648033 0.4097596 4.021952 0.0000577 0.0001941
CD74 104855.0678 -1.639918 0.3985839 -4.114360 0.0000388 0.0001352
SPI1 9747.6288 -1.637524 0.4766786 -3.435280 0.0005919 0.0015370
PRKCD 17121.7438 -1.594292 0.2552943 -6.244919 0.0000000 0.0000000
DBH 1223.2051 -1.573010 0.1929283 -8.153341 0.0000000 0.0000000
CDH7 2754.5287 -1.562227 0.4535669 -3.444315 0.0005725 0.0015131
BACE1 49613.0136 -1.544059 0.1473621 -10.477987 0.0000000 0.0000000
CAMK2G 84752.0351 -1.539843 0.2251320 -6.839731 0.0000000 0.0000000
CSF1 10560.2258 -1.515836 0.2037734 -7.438833 0.0000000 0.0000000
TLR4 3711.2648 1.507040 0.2972595 5.069779 0.0000004 0.0000020
SOX10 77987.3289 -1.506085 0.3021871 -4.983950 0.0000006 0.0000030
MS4A7 1980.6393 1.488433 0.2355058 6.320153 0.0000000 0.0000000
INPP5D 19173.0397 -1.487025 0.3048244 -4.878302 0.0000011 0.0000048
TREM2 5048.9133 -1.483212 0.2358210 -6.289566 0.0000000 0.0000000
HTR1A 2684.6540 -1.478658 0.2753891 -5.369341 0.0000001 0.0000004
WNT2 633.5141 1.473197 0.3277980 4.494221 0.0000070 0.0000272
OLIG1 17725.1960 1.468817 0.3047467 4.819797 0.0000014 0.0000062
THEMIS 1286.4018 -1.418237 0.2876932 -4.929685 0.0000008 0.0000038
TH 1561.6196 -1.402319 0.2851797 -4.917317 0.0000009 0.0000040
MRC2 9614.0281 -1.401374 0.3027323 -4.629087 0.0000037 0.0000151
IL10 569.8812 1.378284 0.2675873 5.150781 0.0000003 0.0000013
SCIMP 1179.6339 -1.376017 0.2068501 -6.652241 0.0000000 0.0000000
MTOR 6141.3886 1.369079 0.3160344 4.332058 0.0000148 0.0000553
SLC6A4 888.3102 -1.366935 0.3809283 -3.588432 0.0003327 0.0009034
ADGRA1 26558.6013 -1.366717 0.2015838 -6.779892 0.0000000 0.0000000
TNF 1275.9038 1.361001 0.2607774 5.219017 0.0000002 0.0000010
SYN1 93115.0065 -1.343238 0.3437184 -3.907959 0.0000931 0.0003028
RSPO1 740.9538 -1.342887 0.3757122 -3.574244 0.0003512 0.0009452
CALB2 8087.8958 1.319462 0.2114885 6.238931 0.0000000 0.0000000
CALB1 3058.4410 1.316861 0.5497699 2.395295 0.0166070 0.0315107
TSHZ1 12382.6165 -1.304771 0.2426078 -5.378108 0.0000001 0.0000004
NOS1 8516.2284 -1.295660 0.3175886 -4.079682 0.0000451 0.0001552
SLC17A7 87196.7635 -1.279864 0.2496045 -5.127569 0.0000003 0.0000015
ACE 3379.6983 -1.278600 0.2068934 -6.179992 0.0000000 0.0000000
SNCG 24857.5916 -1.257202 0.2189195 -5.742761 0.0000000 0.0000001
BDKRB1 605.6795 -1.247884 0.3892670 -3.205729 0.0013472 0.0032686
NDST4 539.6998 1.242686 0.3222970 3.855718 0.0001154 0.0003634
SYNGAP1 86464.1372 -1.226274 0.2529273 -4.848324 0.0000012 0.0000055
CHRNA5 934.1902 1.214986 0.2509702 4.841158 0.0000013 0.0000056
IL1B 1616.5859 1.210718 0.5471742 2.212673 0.0269202 0.0474087
ERBB2 6020.2458 -1.207482 0.3200309 -3.773016 0.0001613 0.0004822
DLK1 800.6403 1.205097 0.5145928 2.341846 0.0191886 0.0357223
COL11A1 8572.7779 1.202174 0.2000881 6.008222 0.0000000 0.0000000
PTK2B 43937.6410 -1.175081 0.2531423 -4.641980 0.0000035 0.0000144
VIP 2974.2819 1.165792 0.4182245 2.787479 0.0053120 0.0111514
KCNC1 26237.7740 -1.164357 0.3030004 -3.842756 0.0001217 0.0003791
GPR15 619.1832 1.157212 0.3092066 3.742522 0.0001822 0.0005393
HS3ST1 3238.4045 -1.146838 0.3153823 -3.636342 0.0002765 0.0007650
BIN1 142797.1102 -1.138472 0.4081751 -2.789176 0.0052842 0.0111514
PILRA 4097.7667 1.128833 0.3034353 3.720178 0.0001991 0.0005834
OPN3 3124.8536 1.095974 0.4019130 2.726894 0.0063934 0.0131419
SLC29A2 4242.6742 1.094583 0.2815131 3.888211 0.0001010 0.0003249
NTNG2 9264.2365 -1.075223 0.2842195 -3.783075 0.0001549 0.0004679
ADGRG7 385.5928 1.069946 0.2594532 4.123849 0.0000373 0.0001313
SHARPIN 7126.6591 -1.065966 0.3248322 -3.281589 0.0010322 0.0025893
BCL11B 6954.6037 -1.052317 0.2661953 -3.953178 0.0000771 0.0002565
FERMT2 5422.6979 1.046030 0.2496489 4.190007 0.0000279 0.0001007
ADRB1 8232.0723 1.030563 0.2495494 4.129698 0.0000363 0.0001295
AQP4 20655.0744 1.028441 0.3952102 2.602263 0.0092611 0.0181636
PAX6 10568.9615 -1.025487 0.3179093 -3.225721 0.0012566 0.0030995
ADARB2 11355.7530 1.024988 0.4636825 2.210538 0.0270678 0.0474087
CST7 469.8917 -1.023855 0.2029317 -5.045319 0.0000005 0.0000022
ITGA7 32097.4946 -1.023414 0.3564187 -2.871381 0.0040868 0.0088299
SORL1 61557.0171 -1.020904 0.1674758 -6.095831 0.0000000 0.0000000
CCKBR 7617.3445 -1.008808 0.2278290 -4.427916 0.0000095 0.0000361
TRPM4 6292.9152 -1.004985 0.3172868 -3.167435 0.0015379 0.0036861

6.2 Astrocyte

X baseMean log2FoldChange lfcSE stat pvalue padj
CHODL 1819.84655 6.694103 1.5622536 4.284902 0.0000183 0.0000946
GRM5 594.19327 5.891105 0.5992189 9.831308 0.0000000 0.0000000
GPHN 768.65210 5.386108 0.3770165 14.286134 0.0000000 0.0000000
SIM1 478.02520 5.112587 1.3783527 3.709201 0.0002079 0.0008090
GRIA4 323.52976 5.001913 0.4043258 12.370999 0.0000000 0.0000000
IFNG 2076.57330 4.940661 0.6381759 7.741848 0.0000000 0.0000000
SCTR 284.12071 4.694662 0.8019823 5.853823 0.0000000 0.0000000
NOS3 246.72166 4.078517 0.7343231 5.554118 0.0000000 0.0000002
DLG4 2218.45722 4.045893 0.3034787 13.331719 0.0000000 0.0000000
RIMS1 511.17939 3.994107 0.3222864 12.393038 0.0000000 0.0000000
SEMA5B 1999.00564 3.858389 1.4389054 2.681475 0.0073298 0.0177238
C3 1753.45604 -3.806749 1.3448875 -2.830533 0.0046470 0.0120252
ROS1 162.80489 3.685655 0.4119504 8.946842 0.0000000 0.0000000
CREBBP 4777.11217 -3.662592 0.2563606 -14.286877 0.0000000 0.0000000
CXCL10 522.71459 3.625022 1.2901990 2.809661 0.0049594 0.0126122
CACNG5 134.74713 3.392719 0.3754480 9.036455 0.0000000 0.0000000
MKI67 387.44575 3.204019 0.8438787 3.796776 0.0001466 0.0006006
IGF2 349.80114 3.157754 0.8471752 3.727392 0.0001935 0.0007818
ICAM1 410.27474 -2.982423 0.8603897 -3.466363 0.0005276 0.0018309
DCN 195.79636 2.967766 0.3758362 7.896434 0.0000000 0.0000000
CD74 2673.02349 -2.953381 1.0700616 -2.760010 0.0057800 0.0144499
INPP5D 1154.49646 -2.728381 0.6408999 -4.257110 0.0000207 0.0001053
NR5A1 183.08935 2.714669 0.5831691 4.655029 0.0000032 0.0000199
MEIS2 1685.67026 2.637961 0.2344578 11.251323 0.0000000 0.0000000
CD4 171.35254 -2.607766 0.3554656 -7.336199 0.0000000 0.0000000
PTEN 274.07601 2.543331 0.3769716 6.746744 0.0000000 0.0000000
LAMP5 859.25652 2.518818 0.3006821 8.377014 0.0000000 0.0000000
PENK 133.63349 2.451003 0.3516540 6.969928 0.0000000 0.0000000
PRSS12 86.26600 2.289959 0.4795074 4.775649 0.0000018 0.0000117
CRH 100.90247 2.265751 0.3088219 7.336755 0.0000000 0.0000000
KCNQ1 77.16263 -2.257145 0.2847393 -7.927057 0.0000000 0.0000000
MAPK1 1607.86828 2.223523 0.2988396 7.440523 0.0000000 0.0000000
HTR1A 71.17693 -2.197500 0.3021280 -7.273407 0.0000000 0.0000000
MTOR 603.03972 2.148243 0.2565697 8.372944 0.0000000 0.0000000
CST7 50.85678 -2.144183 0.4317716 -4.966012 0.0000007 0.0000049
CHRNA5 96.66573 2.142851 0.3557424 6.023604 0.0000000 0.0000000
NRG3 929.04973 2.073946 0.1959924 10.581762 0.0000000 0.0000000
SLC6A4 68.67662 -2.056120 0.5091683 -4.038192 0.0000539 0.0002445
GPR15 41.39499 2.035436 0.4618028 4.407587 0.0000105 0.0000593
NEGR1 234.57551 2.021147 0.3612932 5.594201 0.0000000 0.0000002
P2RY12 89.75925 1.997038 0.3959104 5.044166 0.0000005 0.0000034
GRIN3B 125.66819 1.969225 0.4701541 4.188467 0.0000281 0.0001381
PCP4 112.71524 1.929571 0.4308063 4.478976 0.0000075 0.0000443
CSF1 3889.25987 -1.895085 0.2851234 -6.646542 0.0000000 0.0000000
SNCA 535.29728 1.892247 0.2844958 6.651231 0.0000000 0.0000000
RIMS2 138.47975 1.866658 0.3793921 4.920128 0.0000009 0.0000061
SPI1 169.01307 -1.861904 0.5728554 -3.250216 0.0011532 0.0036977
KCND2 645.97132 -1.823311 0.3868906 -4.712730 0.0000024 0.0000157
DBH 75.24390 -1.809003 0.3122461 -5.793515 0.0000000 0.0000001
RELN 85.69460 1.798383 0.3319694 5.417315 0.0000001 0.0000005
ADAM10 147.35448 1.784882 0.6261544 2.850545 0.0043644 0.0113939
PRKCD 502.43845 -1.770570 0.2948372 -6.005247 0.0000000 0.0000000
CX3CL1 928.56996 -1.744907 0.4495677 -3.881301 0.0001039 0.0004379
MAP4K3 760.75819 1.694357 0.2569497 6.594121 0.0000000 0.0000000
HLA-DMB 59.53603 -1.684440 0.5858189 -2.875360 0.0040357 0.0106297
TH 95.99234 -1.677139 0.3900623 -4.299669 0.0000171 0.0000901
SULF2 192.21083 -1.631846 0.5333485 -3.059623 0.0022162 0.0063472
BDKRB1 30.65876 -1.610951 0.4823646 -3.339695 0.0008387 0.0028439
BACE1 2134.69691 -1.608648 0.2488594 -6.464082 0.0000000 0.0000000
ERBB2 3610.53882 -1.605596 0.3106618 -5.168307 0.0000002 0.0000018
MRC2 592.24921 -1.591174 0.5656055 -2.813222 0.0049048 0.0125818
TLR4 2249.21434 1.581308 0.3250876 4.864250 0.0000011 0.0000077
PKP2 158.99839 -1.552312 0.5134456 -3.023322 0.0025002 0.0070243
PDGFRA 115.44275 1.537230 0.6202284 2.478490 0.0131940 0.0292649
LGALS3 1434.52892 -1.521665 0.2793557 -5.447053 0.0000001 0.0000004
OLIG1 465.55177 1.503309 0.2409833 6.238230 0.0000000 0.0000000
SYT6 60.90397 -1.498519 0.3535034 -4.239051 0.0000224 0.0001122
IL1B 73.19315 1.498150 0.5730491 2.614348 0.0089398 0.0210979
FIBCD1 66.94239 1.467247 0.3564700 4.116047 0.0000385 0.0001805
CAMK2G 25875.10774 -1.440218 0.3332367 -4.321908 0.0000155 0.0000830
MS4A7 65.95022 1.421419 0.5699958 2.493736 0.0126407 0.0284304
CTNNA3 70.03597 1.419853 0.3599522 3.944560 0.0000799 0.0003520
NPAS1 74.68930 -1.419176 0.5359974 -2.647729 0.0081034 0.0192783
KCTD4 52.54530 1.413563 0.4564678 3.096743 0.0019566 0.0058303
PTK2B 1652.23788 -1.383340 0.2338225 -5.916197 0.0000000 0.0000000
TACR2 42.59861 1.380939 0.3727701 3.704533 0.0002118 0.0008114
TSHZ1 1332.75569 -1.363388 0.2084189 -6.541575 0.0000000 0.0000000
SORL1 9782.86718 -1.357761 0.2309157 -5.879900 0.0000000 0.0000000
CASS4 90.54747 1.341102 0.2982683 4.496295 0.0000069 0.0000416
GAD2 75.08892 1.330876 0.4378771 3.039383 0.0023706 0.0067244
MUSK 109.71273 -1.323634 0.4557935 -2.904020 0.0036840 0.0098799
RSPO1 38.86291 -1.297118 0.3918085 -3.310592 0.0009310 0.0031209
TRPM4 1300.23478 -1.294440 0.4346961 -2.977804 0.0029032 0.0080797
ADGRA1 455.34146 -1.288002 0.2647951 -4.864145 0.0000011 0.0000077
NXPH4 68.12224 1.287584 0.4202233 3.064048 0.0021836 0.0063154
SHARPIN 895.29341 -1.255025 0.3860995 -3.250523 0.0011519 0.0036977
SNCG 2119.68867 -1.252879 0.3608142 -3.472365 0.0005159 0.0018118
TAC1 94.73297 1.249630 0.3874317 3.225420 0.0012579 0.0039060
ITGA7 18974.01094 -1.247976 0.3647723 -3.421247 0.0006233 0.0021382
HTR3A 71.97826 -1.243347 0.4002325 -3.106561 0.0018928 0.0056976
SYN1 1583.90946 -1.238420 0.4295905 -2.882792 0.0039417 0.0104756
NPY1R 40.37699 1.238274 0.4810563 2.574073 0.0100509 0.0231642
SYNGAP1 8911.06835 -1.184470 0.4373328 -2.708395 0.0067609 0.0166207
NOS1 206.55580 -1.176125 0.5105109 -2.303820 0.0212328 0.0438211
NTNG2 2973.81898 -1.174496 0.4384507 -2.678741 0.0073899 0.0177238
SLCO2A1 41.41941 1.158339 0.3981810 2.909076 0.0036250 0.0098107
THEMIS 62.32583 -1.144445 0.3472950 -3.295309 0.0009831 0.0032587
ADARB2 102.51294 1.136249 0.3197807 3.553213 0.0003806 0.0014033
CAMK2A 1463.99374 1.130100 0.2769881 4.079958 0.0000450 0.0002076
ITGAX 105.61173 -1.129599 0.2596814 -4.349942 0.0000136 0.0000744
GRIA2 6902.00979 1.124970 0.2556917 4.399711 0.0000108 0.0000603
CD79A 97.33703 1.122738 0.2850714 3.938447 0.0000820 0.0003558
PDGFRB 9141.79477 -1.099957 0.2990062 -3.678710 0.0002344 0.0008866
SCIMP 72.30973 -1.099341 0.2743137 -4.007605 0.0000613 0.0002742
CALB2 50.22089 1.086052 0.3997960 2.716515 0.0065973 0.0163547
PAX6 8987.35306 -1.081086 0.2607583 -4.145932 0.0000338 0.0001637
PSEN2 915.25987 -1.069032 0.3068933 -3.483399 0.0004951 0.0017597
LY9 125.97353 -1.066187 0.2864800 -3.721681 0.0001979 0.0007889
ACE 159.27116 -1.065968 0.3457277 -3.083260 0.0020475 0.0060400
CDH7 84.53609 -1.048139 0.3336074 -3.141834 0.0016789 0.0051060
CD33 119.96147 1.031598 0.2632065 3.919349 0.0000888 0.0003796
FN1 705.98788 -1.021086 0.3122979 -3.269588 0.0010770 0.0035303
RORB 2641.65042 -1.011495 0.3443011 -2.937821 0.0033053 0.0091127
AQP4 16262.71646 1.004155 0.4262698 2.355679 0.0184889 0.0386825

6.3 Endothelial

X baseMean log2FoldChange lfcSE stat pvalue padj
GPHN 105.397147 6.872375 0.9231475 7.444504 0.0000000 0.0000000
GRM5 60.212097 6.084098 0.9403392 6.470110 0.0000000 0.0000000
GRIA4 28.671707 4.931340 0.9443380 5.222008 0.0000002 0.0000028
P2RY12 60.655966 4.852388 0.7190922 6.747936 0.0000000 0.0000000
DLG4 154.974583 4.540505 0.5111288 8.883289 0.0000000 0.0000000
SEMA5B 84.945813 4.264285 0.7537764 5.657228 0.0000000 0.0000003
ROS1 17.920048 4.233761 0.9785961 4.326362 0.0000152 0.0001260
CRH 11.874282 4.229943 1.1611717 3.642823 0.0002697 0.0013992
PTEN 96.969080 3.994704 0.6505167 6.140816 0.0000000 0.0000000
FLT1 3718.932617 3.953958 0.3701657 10.681589 0.0000000 0.0000000
IFNG 151.862551 3.894761 0.5053816 7.706575 0.0000000 0.0000000
SIM1 13.763803 3.802401 1.1031418 3.446883 0.0005671 0.0026937
CREBBP 1674.625511 -3.749443 0.3815023 -9.828099 0.0000000 0.0000000
RELN 25.828359 3.704195 0.7520922 4.925187 0.0000008 0.0000107
NR5A1 24.519446 3.574405 0.7808126 4.577801 0.0000047 0.0000463
CHODL 67.168290 3.521006 0.7449427 4.726547 0.0000023 0.0000243
CACNG5 45.498939 3.381748 0.5696623 5.936408 0.0000000 0.0000001
DBH 32.079022 -2.904256 0.5228394 -5.554776 0.0000000 0.0000005
CCR6 21.842622 -2.834969 0.5532148 -5.124535 0.0000003 0.0000044
SCTR 17.322809 2.787078 0.7387125 3.772886 0.0001614 0.0009133
CTSS 35.546299 2.711786 0.5608086 4.835493 0.0000013 0.0000154
GRIN3B 18.398343 2.684172 0.7610409 3.526975 0.0004203 0.0020705
CXCL10 23.910550 2.650536 0.7281380 3.640157 0.0002725 0.0013992
NXPH4 32.892945 2.617323 0.5982749 4.374783 0.0000122 0.0001078
FEZF2 65.269918 -2.608922 0.4131996 -6.313952 0.0000000 0.0000000
MUSK 13.949806 -2.575487 0.6323269 -4.073031 0.0000464 0.0002939
PILRA 51.813016 2.552705 0.5939819 4.297615 0.0000173 0.0001337
SNCA 81.107497 2.514225 0.4420304 5.687902 0.0000000 0.0000003
NOS3 1102.610564 2.469713 0.3259451 7.577082 0.0000000 0.0000000
ADAM10 78.771542 2.378449 0.6201768 3.835114 0.0001255 0.0007258
GAD2 9.178752 2.335659 0.8756001 2.667495 0.0076419 0.0267466
NEGR1 37.028556 2.334610 0.6265921 3.725885 0.0001946 0.0010786
NRG3 33.964332 2.325276 0.5561394 4.181103 0.0000290 0.0002128
MTOR 148.614203 2.265180 0.4214983 5.374113 0.0000001 0.0000013
MEIS2 33.018637 2.195545 0.5622354 3.905027 0.0000942 0.0005569
MAPK1 315.321825 2.188328 0.3656681 5.984466 0.0000000 0.0000001
CELSR1 32.498998 2.178100 0.5540784 3.931033 0.0000846 0.0005113
RIMS1 43.407059 2.163590 0.5837469 3.706383 0.0002102 0.0011413
OPRM1 31.186347 -2.163396 0.4823109 -4.485480 0.0000073 0.0000691
RIMS2 35.611353 2.150232 0.5227434 4.113360 0.0000390 0.0002660
LAMP5 75.076885 2.032214 0.4279807 4.748378 0.0000021 0.0000227
PENK 22.821861 1.999423 0.5860232 3.411849 0.0006452 0.0030111
CHRNA5 11.613890 1.993956 0.7725671 2.580948 0.0098529 0.0331757
GRIA2 110.869550 1.929307 0.4421524 4.363443 0.0000128 0.0001099
PRKCD 147.959376 -1.920624 0.3952769 -4.858933 0.0000012 0.0000143
CX3CL1 1043.255411 -1.894131 0.4017526 -4.714670 0.0000024 0.0000248
TLX3 11.742405 -1.881562 0.7774148 -2.420281 0.0155085 0.0491103
MAP4K3 279.445125 1.780267 0.3522561 5.053902 0.0000004 0.0000061
SPI1 63.980321 -1.763922 0.5420216 -3.254339 0.0011366 0.0048762
CST7 12.429918 -1.719700 0.6263627 -2.745534 0.0060412 0.0214263
SYT6 15.793590 -1.712200 0.6119140 -2.798105 0.0051403 0.0185445
DCN 269.776035 1.662474 0.5047213 3.293844 0.0009883 0.0043813
CD74 4747.484295 -1.641053 0.3822290 -4.293377 0.0000176 0.0001337
MRC2 118.727294 -1.626714 0.3989426 -4.077563 0.0000455 0.0002939
MS4A4A 30.898018 -1.611109 0.5061979 -3.182766 0.0014588 0.0060630
OLIG1 98.112992 1.581913 0.4346915 3.639164 0.0002735 0.0013992
INPP5D 3313.777745 -1.514745 0.3695073 -4.099365 0.0000414 0.0002755
SNCG 529.758151 -1.511691 0.3054744 -4.948666 0.0000007 0.0000099
IGF2 1040.097708 -1.491283 0.3570609 -4.176552 0.0000296 0.0002128
PDGFRB 385.274236 -1.486095 0.3450191 -4.307284 0.0000165 0.0001332
TREM2 21.165074 -1.479298 0.5744702 -2.575065 0.0100221 0.0333236
EPHA7 56.429594 1.465798 0.4489681 3.264814 0.0010954 0.0047765
CAMK2G 635.818566 -1.445333 0.3268815 -4.421581 0.0000098 0.0000899
TBX1 144.769468 -1.432017 0.5119867 -2.796981 0.0051583 0.0185445
CSF1 438.981538 -1.401881 0.3404953 -4.117183 0.0000384 0.0002660
ERBB4 41.479900 1.377118 0.4682478 2.941003 0.0032715 0.0127974
NPNT 49.576279 1.365229 0.4431369 3.080829 0.0020642 0.0083195
DEPTOR 1077.027752 -1.365196 0.4689701 -2.911053 0.0036021 0.0138475
NR2F2 261.518485 1.346924 0.3413142 3.946288 0.0000794 0.0004910
SHARPIN 339.889787 -1.343778 0.4310370 -3.117548 0.0018236 0.0074628
KCNQ1 212.744550 -1.335741 0.4631059 -2.884310 0.0039227 0.0146964
SYNGAP1 695.993797 -1.285596 0.3851652 -3.337778 0.0008445 0.0038731
ITGA7 188.064538 -1.282343 0.3686858 -3.478146 0.0005049 0.0024419
CD33 34.287898 1.274061 0.4810400 2.648555 0.0080837 0.0279254
BACE1 372.503581 -1.166499 0.3228712 -3.612893 0.0003028 0.0015197
SYN1 285.626876 -1.165271 0.4166240 -2.796936 0.0051590 0.0185445
OPALIN 158.433853 1.110707 0.4426832 2.509034 0.0121062 0.0392713
PTK2B 349.536248 -1.106025 0.3734177 -2.961897 0.0030575 0.0121387
LRATD2 395.453221 -1.100806 0.3438311 -3.201589 0.0013667 0.0057706
APP 10412.461440 -1.076211 0.3253214 -3.308148 0.0009392 0.0042341
FERMT2 195.081444 1.065227 0.4062786 2.621913 0.0087438 0.0298185
KCND2 36.401913 -1.062125 0.4370243 -2.430357 0.0150840 0.0483414

6.4 L2_3_4 IT

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 1414.10723 5.724100 0.6095089 9.391330 0.0000000 0.0000000
GRIA4 5238.99619 5.698078 0.2174273 26.206820 0.0000000 0.0000000
GRM5 1705.73923 5.157038 0.2494547 20.673248 0.0000000 0.0000000
GPHN 1232.79751 4.479422 0.3416514 13.111089 0.0000000 0.0000000
CHODL 747.36371 4.456506 1.3874314 3.212055 0.0013179 0.0037873
DLG4 5081.68264 4.412676 0.2592517 17.020816 0.0000000 0.0000000
NOS3 411.46501 3.952416 0.5539703 7.134709 0.0000000 0.0000000
RIMS1 1806.46970 3.456719 0.3933298 8.788347 0.0000000 0.0000000
MEIS2 1278.98223 3.387079 0.4687771 7.225350 0.0000000 0.0000000
SNCA 3308.76313 3.382261 0.3271699 10.337934 0.0000000 0.0000000
PCP4 174.89252 3.092448 0.3818959 8.097622 0.0000000 0.0000000
CXCL10 279.98073 3.052312 0.7361045 4.146575 0.0000337 0.0001561
PTEN 394.29465 2.981078 0.6037612 4.937512 0.0000008 0.0000044
CREBBP 4280.81337 -2.970685 0.2585912 -11.487959 0.0000000 0.0000000
CTSS 153.69233 2.911577 0.3645472 7.986830 0.0000000 0.0000000
NR5A1 322.06219 2.910149 0.2790201 10.429889 0.0000000 0.0000000
NOS1 299.83028 -2.829230 0.2558768 -11.057002 0.0000000 0.0000000
TACR2 159.39548 2.730509 0.5139937 5.312340 0.0000001 0.0000007
SCTR 118.81128 2.637707 0.3375050 7.815313 0.0000000 0.0000000
MKI67 349.03996 2.628956 0.7545083 3.484330 0.0004934 0.0016181
WNT2 191.18577 2.598276 0.3399989 7.642013 0.0000000 0.0000000
AGTR1 107.27282 2.500924 0.5476623 4.566543 0.0000050 0.0000257
GRIN3B 245.09011 2.464172 0.4524959 5.445734 0.0000001 0.0000004
P2RY12 160.22010 2.428406 0.4587155 5.293927 0.0000001 0.0000008
ROS1 390.67261 2.276594 0.2996401 7.597762 0.0000000 0.0000000
THEMIS 168.75071 -2.258217 0.4376833 -5.159478 0.0000002 0.0000015
MAPK1 4073.36415 2.241834 0.2384605 9.401280 0.0000000 0.0000000
DCN 159.09729 2.241737 0.3374432 6.643303 0.0000000 0.0000000
CX3CL1 4712.81710 -2.212191 0.2220618 -9.962053 0.0000000 0.0000000
SPI1 264.57839 -2.189665 0.6288304 -3.482124 0.0004975 0.0016181
NPY1R 899.02616 2.167603 0.4326587 5.009960 0.0000005 0.0000032
MAP4K3 1262.53471 2.100587 0.2244849 9.357363 0.0000000 0.0000000
NEGR1 1930.97863 2.070587 0.2769092 7.477496 0.0000000 0.0000000
KCTD4 305.90590 2.061354 0.4076831 5.056267 0.0000004 0.0000025
MTOR 859.85760 2.011567 0.2720109 7.395170 0.0000000 0.0000000
FIBCD1 156.26762 1.996249 0.4433976 4.502165 0.0000067 0.0000342
SYT6 211.88059 -1.982892 0.6310932 -3.141995 0.0016780 0.0046420
PILRA 569.98700 1.956839 0.4187756 4.672762 0.0000030 0.0000160
CA12 77.54382 -1.908195 0.3014348 -6.330376 0.0000000 0.0000000
AQP4 479.10599 1.904241 0.4887204 3.896382 0.0000976 0.0003854
CAMK2G 10969.06461 -1.899264 0.2817127 -6.741846 0.0000000 0.0000000
NRG3 1440.35096 1.897574 0.2586487 7.336492 0.0000000 0.0000000
PDYN 839.56820 -1.887674 0.3285593 -5.745308 0.0000000 0.0000001
RIMS2 1975.08955 1.877842 0.2095077 8.963114 0.0000000 0.0000000
HS3ST1 700.68234 -1.843978 0.3289400 -5.605819 0.0000000 0.0000002
ACE 649.02857 -1.836986 0.3567475 -5.149261 0.0000003 0.0000016
TYROBP 165.20760 -1.785821 0.2564182 -6.964486 0.0000000 0.0000000
ADGRA1 4382.61546 -1.768863 0.1648095 -10.732774 0.0000000 0.0000000
ERBB4 270.21190 1.758982 0.4659175 3.775309 0.0001598 0.0005988
TSHZ1 2387.69630 -1.743494 0.3339579 -5.220699 0.0000002 0.0000011
SIM1 181.00078 1.721225 0.6716441 2.562704 0.0103861 0.0231148
SOX10 644.35967 -1.694829 0.4092363 -4.141445 0.0000345 0.0001572
BIN1 17456.04687 -1.693056 0.4843997 -3.495163 0.0004738 0.0015845
DLK1 141.93330 1.688238 0.5363631 3.147567 0.0016464 0.0045974
TH 230.33644 -1.646592 0.4388622 -3.751958 0.0001755 0.0006412
MRC1 153.67001 1.640824 0.4098830 4.003152 0.0000625 0.0002611
DBH 318.39924 -1.638913 0.2907291 -5.637252 0.0000000 0.0000002
PENK 296.64402 1.607675 0.5229344 3.074334 0.0021097 0.0056771
SYN1 22334.11370 -1.564147 0.3663339 -4.269730 0.0000196 0.0000920
SNCG 4120.49224 -1.562270 0.3805987 -4.104770 0.0000405 0.0001788
CD74 1196.86678 -1.548711 0.4693207 -3.299898 0.0009672 0.0028629
ROBO1 1179.48790 1.528919 0.2523187 6.059474 0.0000000 0.0000000
KCNC1 5933.60145 -1.496276 0.3680284 -4.065654 0.0000479 0.0002085
CREB1 126.28493 1.495265 0.5437669 2.749828 0.0059627 0.0147079
PRKCD 3122.08730 -1.486625 0.2666479 -5.575238 0.0000000 0.0000002
BACE1 4413.97109 -1.479332 0.2407567 -6.144511 0.0000000 0.0000000
TRPM4 402.46827 -1.478238 0.2629636 -5.621456 0.0000000 0.0000002
COL11A1 719.07692 1.466579 0.5972382 2.455602 0.0140649 0.0297372
OLIG1 195.23184 1.465696 0.3661785 4.002681 0.0000626 0.0002611
SLC17A7 25001.95521 -1.427496 0.2630715 -5.426265 0.0000001 0.0000004
GPR15 101.14423 1.423103 0.3219565 4.420171 0.0000099 0.0000487
CACNG5 195.70943 1.414950 0.3684402 3.840377 0.0001228 0.0004785
SST 281.92916 -1.405312 0.6174144 -2.276124 0.0228386 0.0427862
BCL11B 510.37172 -1.394837 0.2599860 -5.365047 0.0000001 0.0000006
RELN 170.95931 1.384287 0.3353117 4.128361 0.0000365 0.0001639
CHRNA5 95.40491 1.349446 0.3323593 4.060202 0.0000490 0.0002103
ADGRG7 61.14773 1.348038 0.5084545 2.651246 0.0080195 0.0185452
SYNGAP1 25353.29365 -1.348024 0.2713296 -4.968215 0.0000007 0.0000038
ECHDC3 491.02965 -1.343345 0.2274148 -5.907025 0.0000000 0.0000000
ID4 113.29475 1.335697 0.3575266 3.735937 0.0001870 0.0006751
MS4A4A 78.12706 1.310539 0.4104120 3.193228 0.0014069 0.0039662
SLC6A4 160.43350 -1.305336 0.3849850 -3.390614 0.0006974 0.0021502
HTR1A 1137.63939 -1.298857 0.4530780 -2.866741 0.0041472 0.0103158
OPN3 693.10022 1.294974 0.3651883 3.546043 0.0003911 0.0013305
FEZF2 187.13191 -1.289924 0.4436391 -2.907599 0.0036422 0.0092938
NTNG2 552.79103 -1.280799 0.3608046 -3.549842 0.0003855 0.0013267
CD79A 162.12271 -1.266193 0.3367760 -3.759749 0.0001701 0.0006293
KCNQ1 103.20503 -1.262285 0.2952036 -4.275982 0.0000190 0.0000920
PTK2B 19312.30735 -1.253037 0.3384506 -3.702275 0.0002137 0.0007620
IL10 84.23095 1.246898 0.3628233 3.436653 0.0005889 0.0018465
SLC29A2 576.64581 1.238736 0.3250609 3.810781 0.0001385 0.0005257
NDNF 87.77478 -1.188095 0.3638112 -3.265691 0.0010920 0.0032002
IGF2 135.31502 1.186190 0.3410782 3.477764 0.0005056 0.0016268
CUX2 11841.32374 -1.182885 0.2628934 -4.499487 0.0000068 0.0000342
PSEN2 2294.99732 -1.173339 0.2236655 -5.245953 0.0000002 0.0000010
NDST4 44.40551 1.172480 0.3356012 3.493670 0.0004764 0.0015845
PDGFRA 211.41542 1.161419 0.5016575 2.315163 0.0206040 0.0398613
TAC1 147.40313 1.161037 0.3513361 3.304632 0.0009510 0.0028434
TLR4 110.23444 1.157085 0.5020730 2.304615 0.0211881 0.0407252
NPNT 208.74833 1.151046 0.2914234 3.949737 0.0000782 0.0003172
C1QA 138.38346 -1.136638 0.4690844 -2.423099 0.0153887 0.0316324
ADAM10 228.99898 1.128802 0.4602943 2.452350 0.0141927 0.0297945
EPHA10 4893.34362 -1.121976 0.4827603 -2.324085 0.0201210 0.0391829
SYP 29393.76797 -1.121516 0.2865493 -3.913866 0.0000908 0.0003633
CDH7 182.71460 -1.093394 0.4233954 -2.582442 0.0098104 0.0221669
NPTX1 5279.31132 1.080519 0.3480644 3.104365 0.0019069 0.0052263
CSF1 257.93652 -1.071540 0.3494332 -3.066509 0.0021657 0.0057713
ICAM1 122.13957 -1.035491 0.3191058 -3.244976 0.0011746 0.0034087
CCKBR 2070.49883 -1.032441 0.1965625 -5.252482 0.0000002 0.0000010
PLCG2 77.82207 1.024988 0.3035205 3.376998 0.0007328 0.0022362
ETV1 502.01392 1.014865 0.3733697 2.718124 0.0065653 0.0159290
CCR6 58.17102 1.009513 0.3973712 2.540480 0.0110700 0.0242721
UBE3A 1697.29111 1.007687 0.1895249 5.316908 0.0000001 0.0000007

6.5 L5_6 IT

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 2847.52415 6.239040 0.9043592 6.898851 0.0000000 0.0000000
GRIA4 2443.01921 5.643501 0.3033411 18.604474 0.0000000 0.0000000
GRM5 2042.84803 5.432306 0.3551056 15.297720 0.0000000 0.0000000
CHODL 1929.43768 5.311141 1.4444785 3.676857 0.0002361 0.0008629
GPHN 1618.65880 5.023820 0.2824390 17.787277 0.0000000 0.0000000
DLG4 6316.34404 4.337494 0.2870119 15.112597 0.0000000 0.0000000
CXCL10 757.45965 4.063033 1.1733716 3.462699 0.0005348 0.0016663
RIMS1 3227.73161 4.019554 0.3383425 11.880134 0.0000000 0.0000000
NOS3 532.62776 3.860130 0.5011419 7.702669 0.0000000 0.0000000
SCTR 212.98522 3.661916 0.5307039 6.900112 0.0000000 0.0000000
SIM1 465.08494 3.623841 0.7176092 5.049882 0.0000004 0.0000026
NR5A1 375.53481 3.604366 0.4513559 7.985641 0.0000000 0.0000000
SNCA 5831.09089 3.595490 0.2592217 13.870327 0.0000000 0.0000000
MKI67 766.68461 3.334108 1.1481733 2.903837 0.0036862 0.0085915
PTEN 704.24801 3.196165 0.5980722 5.344112 0.0000001 0.0000007
CREBBP 5805.16854 -2.762146 0.2494416 -11.073317 0.0000000 0.0000000
CTSS 150.17912 2.717805 0.3444054 7.891296 0.0000000 0.0000000
TACR2 261.09865 2.556233 0.4247950 6.017569 0.0000000 0.0000000
CX3CL1 5856.11503 -2.369349 0.2234727 -10.602408 0.0000000 0.0000000
AGTR1 109.39685 2.289187 0.4127354 5.546378 0.0000000 0.0000002
NEGR1 2799.04099 2.269343 0.2797251 8.112763 0.0000000 0.0000000
NOS1 411.82694 -2.268805 0.2803424 -8.092979 0.0000000 0.0000000
MAP4K3 1688.40276 2.225716 0.2484869 8.957075 0.0000000 0.0000000
NPY1R 1474.72352 2.220387 0.4442953 4.997548 0.0000006 0.0000033
SPI1 349.53069 -2.209690 0.6235236 -3.543875 0.0003943 0.0012550
MEIS2 466.16752 2.172815 0.2842944 7.642836 0.0000000 0.0000000
MAPK1 4794.52273 2.158751 0.2885949 7.480212 0.0000000 0.0000000
GRIN3B 283.43083 2.138377 0.3631441 5.888507 0.0000000 0.0000000
FOS 817.35873 2.111059 0.5857039 3.604310 0.0003130 0.0010649
NRG3 1693.81482 2.070037 0.2722460 7.603552 0.0000000 0.0000000
ROS1 336.59550 2.066791 0.2947750 7.011421 0.0000000 0.0000000
P2RY12 177.21064 2.030460 0.3836899 5.291930 0.0000001 0.0000009
PCP4 303.19473 1.959702 0.3729542 5.254538 0.0000001 0.0000010
NDST4 77.70848 1.916836 0.3765177 5.090960 0.0000004 0.0000022
MTOR 1033.09290 1.902366 0.3328157 5.715973 0.0000000 0.0000001
BCL11B 898.15719 -1.882025 0.3190563 -5.898725 0.0000000 0.0000000
CD74 1639.47192 -1.873189 0.3600540 -5.202522 0.0000002 0.0000013
MRC1 167.88602 1.847155 0.3212966 5.749066 0.0000000 0.0000001
GPR15 106.12390 1.837038 0.2999330 6.124828 0.0000000 0.0000000
OLIG1 414.76391 1.835573 0.3806226 4.822554 0.0000014 0.0000078
SYT6 677.08521 -1.822372 0.4352468 -4.186985 0.0000283 0.0001213
RIMS2 2266.71518 1.819424 0.2468341 7.371039 0.0000000 0.0000000
COL11A1 1534.90319 1.760368 0.2878154 6.116307 0.0000000 0.0000000
OPN3 1015.80197 1.745024 0.4109223 4.246604 0.0000217 0.0000973
HTR1A 453.96638 -1.731576 0.3820662 -4.532136 0.0000058 0.0000279
PILRA 765.19163 1.730139 0.4266804 4.054883 0.0000502 0.0002062
ACE 1007.86916 -1.726374 0.4352511 -3.966386 0.0000730 0.0002842
PRKCD 2765.05569 -1.717378 0.2837613 -6.052192 0.0000000 0.0000000
TSHZ1 2233.31841 -1.687809 0.2855947 -5.909805 0.0000000 0.0000000
ID4 249.06872 1.685940 0.3739018 4.509044 0.0000065 0.0000306
CAMK2G 18242.46645 -1.682458 0.2163526 -7.776466 0.0000000 0.0000000
ADAM10 389.43158 1.616080 0.5041503 3.205552 0.0013480 0.0035948
SYN1 35305.58350 -1.612453 0.2667607 -6.044568 0.0000000 0.0000000
ITGA7 2937.66212 -1.607106 0.4822430 -3.332565 0.0008605 0.0024652
FOXP2 594.87489 1.606635 0.5277756 3.044163 0.0023333 0.0058038
DBH 360.12657 -1.569021 0.3080210 -5.093876 0.0000004 0.0000022
CA12 91.28894 -1.534226 0.2875444 -5.335615 0.0000001 0.0000007
CREB1 148.76736 1.530447 0.4480494 3.415799 0.0006360 0.0019014
PTK2B 12066.79828 -1.525195 0.3012183 -5.063422 0.0000004 0.0000024
TYROBP 210.27895 -1.505396 0.3396772 -4.431844 0.0000093 0.0000432
CHRNA5 124.96123 1.497759 0.2944223 5.087112 0.0000004 0.0000022
KCNC1 6747.71351 -1.496792 0.3181998 -4.703936 0.0000026 0.0000135
PENK 314.82995 1.483512 0.3363115 4.411124 0.0000103 0.0000468
KCTD4 203.03051 1.476177 0.4585989 3.218884 0.0012869 0.0034629
DCN 189.59860 1.473732 0.3158149 4.666444 0.0000031 0.0000159
DLK1 199.06969 1.469520 0.5339238 2.752302 0.0059178 0.0131704
BACE1 6900.79852 -1.455495 0.2111476 -6.893258 0.0000000 0.0000000
SYNGAP1 24677.57259 -1.448042 0.2736450 -5.291681 0.0000001 0.0000009
EPHA1 192.40170 1.442087 0.3946400 3.654183 0.0002580 0.0009313
SST 405.72506 -1.421158 0.6060268 -2.345042 0.0190249 0.0372939
SNCG 5734.97324 -1.405591 0.3904142 -3.600255 0.0003179 0.0010693
IL10 91.20479 1.400273 0.3326838 4.209019 0.0000256 0.0001133
OXGR1 109.13921 -1.391998 0.5629576 -2.472651 0.0134115 0.0279564
ADGRG7 93.89682 1.362416 0.4090432 3.330739 0.0008662 0.0024652
BIN1 20187.64235 -1.350826 0.3732693 -3.618904 0.0002959 0.0010425
ADGRA1 8247.91203 -1.345368 0.2216044 -6.071038 0.0000000 0.0000000
SLC29A2 906.00631 1.340701 0.3960936 3.384810 0.0007123 0.0020875
NMBR 83.43934 1.339405 0.3706337 3.613823 0.0003017 0.0010480
FEZF2 2143.50678 -1.335427 0.2879034 -4.638455 0.0000035 0.0000179
SCIMP 159.79268 -1.315858 0.2723970 -4.830661 0.0000014 0.0000076
IGF2 204.83235 1.312295 0.4296632 3.054241 0.0022563 0.0057083
HTR3A 168.43129 -1.271207 0.3050740 -4.166880 0.0000309 0.0001287
DRD1 2246.53390 -1.244692 0.3432221 -3.626492 0.0002873 0.0010246
UBE3A 2415.29815 1.240538 0.2254731 5.501935 0.0000000 0.0000003
SLC17A7 38695.92632 -1.221467 0.2039331 -5.989547 0.0000000 0.0000000
HS3ST1 646.30564 -1.203411 0.3202601 -3.757606 0.0001715 0.0006347
CSF1 310.41493 -1.198343 0.2598129 -4.612332 0.0000040 0.0000199
TRPM4 919.95879 -1.197225 0.4270836 -2.803257 0.0050589 0.0115188
RELN 174.47593 1.192826 0.2588525 4.608131 0.0000041 0.0000199
CD79A 190.26234 -1.177231 0.2808196 -4.192125 0.0000276 0.0001203
EPHA10 3220.97229 -1.173910 0.4269724 -2.749382 0.0059708 0.0131892
GAD2 135.65104 1.172069 0.3397770 3.449523 0.0005616 0.0017315
CACNG5 363.29217 1.166045 0.3070722 3.797299 0.0001463 0.0005481
ERBB4 415.81156 1.160562 0.4157107 2.791754 0.0052423 0.0118452
SHARPIN 1009.43107 -1.158032 0.3776387 -3.066507 0.0021658 0.0055388
CCKBR 3202.60724 -1.153365 0.1905473 -6.052905 0.0000000 0.0000000
TH 363.98989 -1.150744 0.4127904 -2.787720 0.0053080 0.0119029
NRG1 1295.39654 -1.128962 0.3457180 -3.265559 0.0010925 0.0029667
NPNT 263.85429 1.123076 0.2815224 3.989296 0.0000663 0.0002651
WNT2 103.92623 1.122749 0.3428595 3.274663 0.0010579 0.0028994
GRIN3A 1887.35582 -1.110143 0.2660844 -4.172148 0.0000302 0.0001276
ICAM1 182.09868 -1.104178 0.2732303 -4.041197 0.0000532 0.0002156
TREM2 135.57861 -1.100798 0.3590531 -3.065837 0.0021706 0.0055388
GRIN1 55714.51435 -1.099636 0.3611159 -3.045105 0.0023260 0.0058038
NDNF 85.30265 -1.093002 0.3078978 -3.549885 0.0003854 0.0012400
ADRB1 2289.16628 1.089772 0.4433187 2.458213 0.0139630 0.0287018
SLC6A4 165.85537 -1.074689 0.3093745 -3.473746 0.0005132 0.0016162
PKP2 75.17802 1.071454 0.3243633 3.303251 0.0009557 0.0026438
NTNG2 2779.97269 -1.071153 0.2240733 -4.780369 0.0000017 0.0000094
SOX10 1428.80280 -1.060088 0.3931436 -2.696440 0.0070085 0.0153668
PSEN2 3024.34293 -1.057626 0.3120210 -3.389597 0.0007000 0.0020719
GPR55 103.82893 1.045147 0.3514086 2.974166 0.0029379 0.0071868
TLR4 134.80392 1.033671 0.4378141 2.360981 0.0182267 0.0364534
SLC32A1 211.99225 1.026122 0.3238011 3.168988 0.0015297 0.0040428
TRHR 149.75686 1.022369 0.3577750 2.857576 0.0042689 0.0098719
ANPEP 113.34187 1.011292 0.3034865 3.332247 0.0008615 0.0024652
NPTX1 7878.93201 1.000784 0.2522103 3.968054 0.0000725 0.0002842
TNF 205.38326 1.000619 0.2801213 3.572091 0.0003541 0.0011647

6.6 L5_6 NP

X baseMean log2FoldChange lfcSE stat pvalue padj
CHODL 228.416965 6.930169 1.6616383 4.170684 0.0000304 0.0003423
CXCL10 64.016175 6.693552 1.0937303 6.119929 0.0000000 0.0000000
IFNG 197.165043 6.413956 0.7604774 8.434117 0.0000000 0.0000000
SCTR 44.119375 6.078005 2.2076942 2.753101 0.0059034 0.0263825
GRM5 131.850010 5.998501 0.6666771 8.997611 0.0000000 0.0000000
GRIA4 268.199104 5.921954 0.5500846 10.765533 0.0000000 0.0000000
GPHN 78.352330 5.708460 0.7250779 7.872893 0.0000000 0.0000000
NOS3 53.445576 5.170710 0.9741095 5.308141 0.0000001 0.0000023
MKI67 56.348173 4.239351 0.9493488 4.465536 0.0000080 0.0001003
DLG4 304.468937 4.110224 0.4082862 10.067016 0.0000000 0.0000000
SIM1 44.270549 4.001679 0.9549157 4.190610 0.0000278 0.0003285
PTEN 38.941928 3.950304 0.7677053 5.145600 0.0000003 0.0000051
CTSS 6.286876 3.902807 1.3335426 2.926646 0.0034264 0.0169949
RIMS1 162.688663 3.771732 0.5191103 7.265763 0.0000000 0.0000000
SNCA 322.080969 3.610596 0.4196148 8.604549 0.0000000 0.0000000
NR5A1 18.070171 3.546346 0.8986025 3.946512 0.0000793 0.0007555
CREBBP 299.938669 -3.004422 0.4051515 -7.415552 0.0000000 0.0000000
MAP4K3 116.868462 2.984437 0.4522584 6.598963 0.0000000 0.0000000
MEIS2 152.181876 2.910296 0.6212608 4.684501 0.0000028 0.0000409
LAMP5 16.322168 2.624458 0.7136364 3.677584 0.0002355 0.0017174
HTR1A 33.835980 -2.467926 0.5968747 -4.134747 0.0000355 0.0003832
SPI1 29.432329 -2.442885 0.7393349 -3.304166 0.0009526 0.0054940
MAPK1 171.415529 2.442337 0.4986871 4.897535 0.0000010 0.0000150
VIPR2 16.127691 -2.405445 0.7572210 -3.176675 0.0014897 0.0078607
CX3CL1 312.039955 -2.394234 0.3950010 -6.061337 0.0000000 0.0000000
PRKCD 38.776508 -2.319285 0.7596752 -3.052995 0.0022657 0.0117061
GRIN3B 15.748870 2.316418 0.7101543 3.261852 0.0011069 0.0062387
ROS1 22.523375 2.296774 0.6463510 3.553447 0.0003802 0.0026941
P2RY12 10.217067 2.190958 0.8429304 2.599215 0.0093437 0.0362069
CACNG5 13.623552 2.176194 0.8032136 2.709358 0.0067414 0.0288251
OLIG1 42.993012 2.170387 0.5402513 4.017367 0.0000589 0.0006028
MTOR 51.328339 2.161466 0.4811192 4.492580 0.0000070 0.0000969
NEGR1 157.435809 2.046614 0.4160335 4.919350 0.0000009 0.0000146
TRPM4 27.935024 -1.931173 0.5753248 -3.356666 0.0007889 0.0047718
ACE 46.135887 -1.895493 0.5020988 -3.775139 0.0001599 0.0012436
NPY1R 27.800113 1.822452 0.6898849 2.641676 0.0082497 0.0337469
SYT6 149.672809 -1.763022 0.3950531 -4.462748 0.0000081 0.0001003
ITGA7 61.994590 -1.700584 0.5771368 -2.946588 0.0032130 0.0162618
HS3ST1 63.726721 -1.684414 0.4462860 -3.774293 0.0001605 0.0012436
NRG3 92.180934 1.634759 0.4179433 3.911437 0.0000917 0.0008126
CAMK2G 1170.840722 -1.540864 0.3134362 -4.916039 0.0000009 0.0000146
PILRA 42.118895 1.535957 0.5829004 2.635025 0.0084131 0.0337469
EPHA10 214.145854 -1.530452 0.4760629 -3.214810 0.0013053 0.0070373
KCNC1 220.098624 -1.511629 0.4685113 -3.226451 0.0012534 0.0069074
ADGRA1 353.682431 -1.457249 0.4311305 -3.380066 0.0007247 0.0045731
SYN1 1216.659802 -1.447488 0.3675925 -3.937751 0.0000822 0.0007555
BACE1 597.456114 -1.435786 0.3580691 -4.009802 0.0000608 0.0006028
SYNGAP1 1166.196217 -1.424617 0.4077888 -3.493516 0.0004767 0.0031952
BCL11B 500.812903 -1.412879 0.3741997 -3.775736 0.0001595 0.0012436
PSEN2 186.878168 -1.364132 0.3948580 -3.454740 0.0005508 0.0035948
COL11A1 397.289237 1.355253 0.3485312 3.888470 0.0001009 0.0008627
SLC29A2 69.911685 1.310516 0.4765306 2.750120 0.0059573 0.0263825
RIMS2 117.672398 1.281637 0.3838420 3.338971 0.0008409 0.0049653
TSHZ1 226.254330 -1.280158 0.4622549 -2.769376 0.0056164 0.0257937
SYP 2270.099494 -1.277014 0.3439385 -3.712913 0.0002049 0.0015398
CCKBR 34.820042 -1.274947 0.4842404 -2.632881 0.0084664 0.0337469
FGFR3 45.293337 -1.266371 0.5114754 -2.475918 0.0132894 0.0499360
NRG1 107.035301 -1.209792 0.4419770 -2.737229 0.0061959 0.0269577
OPALIN 133.923936 1.179372 0.4169921 2.828284 0.0046798 0.0218981
ADAM17 133.621952 -1.149979 0.4323974 -2.659542 0.0078247 0.0328903
NPTX1 445.053990 1.117155 0.4249940 2.628636 0.0085728 0.0337469
SLC17A7 1216.326932 -1.113670 0.3299559 -3.375209 0.0007376 0.0045731
FEZF2 938.785876 -1.080873 0.3085653 -3.502900 0.0004602 0.0031704
RPH3A 1461.376366 -1.007007 0.3505214 -2.872883 0.0040674 0.0196570

6.7 L6b

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 341.01243 5.354484 0.4457571 12.012113 0.0000000 0.0000000
GRM5 287.75018 5.177892 0.5151698 10.050845 0.0000000 0.0000000
GRIA4 181.70967 5.089709 0.4909136 10.367831 0.0000000 0.0000000
CHODL 200.45375 4.830863 0.6143844 7.862932 0.0000000 0.0000000
GPHN 228.47184 4.715876 0.4616666 10.214895 0.0000000 0.0000000
DLG4 995.91791 3.833912 0.4242702 9.036486 0.0000000 0.0000000
RIMS1 513.31219 3.607169 0.4410231 8.179094 0.0000000 0.0000000
CXCL10 109.82057 3.561418 0.4535581 7.852176 0.0000000 0.0000000
SNCA 934.61500 3.440405 0.4005381 8.589456 0.0000000 0.0000000
PTEN 101.61267 3.346554 0.6032107 5.547901 0.0000000 0.0000005
NOS3 79.63960 3.206746 0.5071246 6.323389 0.0000000 0.0000000
AGTR1 28.48605 3.135541 0.6244156 5.021561 0.0000005 0.0000069
CTSS 33.57578 3.026150 0.6066653 4.988171 0.0000006 0.0000078
CREBBP 1031.03904 -2.945548 0.3640731 -8.090540 0.0000000 0.0000000
SIM1 73.27519 2.904113 0.5278259 5.502028 0.0000000 0.0000007
SCTR 25.25303 2.803266 0.6410844 4.372695 0.0000123 0.0001097
MEIS2 365.27962 2.798349 0.3820161 7.325211 0.0000000 0.0000000
NOS1 96.74164 -2.640617 0.4508157 -5.857420 0.0000000 0.0000001
OLIG1 82.61542 2.521022 0.5546261 4.545444 0.0000055 0.0000539
P2RY12 29.53828 2.519820 0.5969009 4.221505 0.0000243 0.0002045
CX3CL1 1513.68240 -2.416760 0.3738100 -6.465211 0.0000000 0.0000000
SYT6 724.41855 -2.386910 0.6315028 -3.779730 0.0001570 0.0010771
NR5A1 54.59304 2.371145 0.5265227 4.503405 0.0000067 0.0000636
NPY1R 219.35377 2.349535 0.4884349 4.810334 0.0000015 0.0000178
GRIN3B 53.46155 2.343378 0.4981690 4.703981 0.0000026 0.0000269
FOS 147.41867 2.319744 0.6242261 3.716192 0.0002022 0.0013560
TACR2 32.60109 2.307993 0.5621645 4.105547 0.0000403 0.0003131
MKI67 97.64982 2.289546 0.5416047 4.227337 0.0000236 0.0002045
MAP4K3 281.59582 2.192186 0.3954492 5.543533 0.0000000 0.0000005
PDYN 179.22990 -2.120471 0.4182663 -5.069667 0.0000004 0.0000056
MAPK1 835.21440 2.058887 0.3959084 5.200413 0.0000002 0.0000031
SPI1 68.25795 -2.057898 0.6206816 -3.315545 0.0009146 0.0048182
PRKCD 581.75834 -2.017561 0.4187993 -4.817488 0.0000015 0.0000178
NRG3 322.96116 1.968655 0.3848701 5.115116 0.0000003 0.0000046
IGF2 50.10649 1.954426 0.5833544 3.350323 0.0008072 0.0043294
CACNG5 41.77723 1.895806 0.5329574 3.557143 0.0003749 0.0022120
TMEM119 36.10576 1.890705 0.5836439 3.239483 0.0011975 0.0059873
SYN1 4493.62349 -1.880488 0.3541374 -5.310050 0.0000001 0.0000018
ROS1 103.53376 1.860812 0.4494844 4.139880 0.0000347 0.0002785
MRC1 21.93051 1.847168 0.6095906 3.030178 0.0024441 0.0110924
SST 74.79717 -1.832985 0.6087675 -3.010977 0.0026041 0.0116395
TSHZ1 397.66583 -1.796035 0.4467486 -4.020236 0.0000581 0.0004398
CHRNA5 23.19293 1.766890 0.6042930 2.923897 0.0034568 0.0149964
ACE 157.35978 -1.759081 0.4250317 -4.138705 0.0000349 0.0002785
NEGR1 481.03406 1.724503 0.3718002 4.638251 0.0000035 0.0000357
COL11A1 260.84812 1.716517 0.4721284 3.635700 0.0002772 0.0017400
PILRA 130.42195 1.709653 0.4793715 3.566447 0.0003619 0.0021785
KCNC1 859.28784 -1.702691 0.4248217 -4.008013 0.0000612 0.0004516
ADGRA1 1772.45214 -1.699124 0.3824487 -4.442751 0.0000089 0.0000819
RIMS2 544.04172 1.691633 0.3593912 4.706939 0.0000025 0.0000269
CAMK2G 5172.71820 -1.665057 0.3521688 -4.728009 0.0000023 0.0000257
RELN 28.49995 1.664563 0.5848188 2.846289 0.0044232 0.0181264
OXGR1 22.92828 -1.638792 0.6817526 -2.403793 0.0162260 0.0495964
CD79A 39.42029 -1.625150 0.5144489 -3.159012 0.0015831 0.0076557
SLC29A2 156.29690 1.616874 0.4635730 3.487852 0.0004869 0.0028165
CTNNA3 31.22030 1.584788 0.5568033 2.846227 0.0044241 0.0181264
HTR3A 22.25106 -1.522850 0.6190027 -2.460167 0.0138872 0.0440509
PTK2B 2237.49686 -1.503851 0.4374201 -3.438002 0.0005860 0.0032014
BACE1 1343.27816 -1.478124 0.3714448 -3.979392 0.0000691 0.0004853
HS3ST1 146.13371 -1.466957 0.4238097 -3.461358 0.0005375 0.0030490
SLC6A4 35.93769 -1.454105 0.5764951 -2.522320 0.0116584 0.0386429
MTOR 179.82912 1.452971 0.3957002 3.671898 0.0002408 0.0015783
SYNGAP1 4876.69907 -1.443817 0.3981517 -3.626298 0.0002875 0.0017670
SLC17A7 6590.27232 -1.440437 0.3617273 -3.982106 0.0000683 0.0004853
LAMP5 98.50754 1.424309 0.5081012 2.803199 0.0050598 0.0201710
HTR1A 264.59026 -1.413695 0.3878283 -3.645158 0.0002672 0.0017137
KCTD4 32.62631 1.407866 0.5307185 2.652754 0.0079838 0.0282046
MRC2 264.78812 -1.380969 0.5022841 -2.749378 0.0059708 0.0234853
ADRB1 284.59780 1.365656 0.3966701 3.442801 0.0005757 0.0032014
SHARPIN 162.01889 -1.297608 0.4495735 -2.886308 0.0038979 0.0166649
PENK 67.29120 1.288237 0.4756458 2.708394 0.0067610 0.0249310
AQP4 136.70522 1.282468 0.4947029 2.592399 0.0095309 0.0326932
DBH 39.60097 -1.276974 0.5141315 -2.483751 0.0130007 0.0416870
TRPM4 192.41794 -1.227035 0.4628998 -2.650758 0.0080311 0.0282046
BCL11B 826.07206 -1.223221 0.3892597 -3.142429 0.0016755 0.0078457
CDH12 253.24297 -1.201917 0.3693561 -3.254085 0.0011376 0.0057860
SYP 6456.38175 -1.193344 0.3648168 -3.271076 0.0010714 0.0055449
NPTX1 1970.64425 1.181716 0.4015070 2.943201 0.0032484 0.0143025
GRIN1 10077.12057 -1.173114 0.4497586 -2.608320 0.0090988 0.0315782
CCKBR 467.52467 -1.166305 0.3667303 -3.180279 0.0014713 0.0072341
SERPINF1 161.57519 -1.137961 0.4199188 -2.709956 0.0067292 0.0249310
UBE3A 453.56764 1.137544 0.3608524 3.152379 0.0016195 0.0077055
SORL1 1780.96704 -1.127229 0.3594896 -3.135637 0.0017148 0.0079042
SNCG 1011.75475 -1.126211 0.4123139 -2.731441 0.0063058 0.0241586
PSEN2 423.18001 -1.091304 0.4066799 -2.683447 0.0072868 0.0265382
EPHA10 382.79303 -1.084883 0.4051047 -2.678032 0.0074056 0.0266421
APP 12582.87391 -1.078978 0.3839647 -2.810096 0.0049527 0.0200142
MAPT 4211.62846 -1.068203 0.3726325 -2.866640 0.0041485 0.0174832
KCND2 312.65085 -1.058480 0.3883976 -2.725248 0.0064253 0.0243009
CRTAC1 644.81076 -1.012735 0.3703615 -2.734450 0.0062485 0.0241586
NNAT 3217.17395 -1.011871 0.4065501 -2.488920 0.0128132 0.0415372
MINK1 1635.97779 -1.008545 0.4120157 -2.447833 0.0143718 0.0451031

6.8 Lamp5

X baseMean log2FoldChange lfcSE stat pvalue padj
GPHN 141.47521 6.060092 0.6720277 9.017622 0.0000000 0.0000000
GRM5 203.00891 5.605468 0.6266163 8.945614 0.0000000 0.0000000
GRIA4 833.58063 5.355684 0.3616108 14.810631 0.0000000 0.0000000
RIMS1 330.04393 4.494384 0.4443001 10.115651 0.0000000 0.0000000
IFNG 112.92356 4.043787 0.5467198 7.396452 0.0000000 0.0000000
DLG4 495.69619 4.041352 0.3694753 10.938084 0.0000000 0.0000000
NOS3 65.39994 3.931675 0.6618808 5.940155 0.0000000 0.0000001
CHODL 57.28381 3.819861 0.7996253 4.777064 0.0000018 0.0000241
SCTR 28.35067 3.785153 0.7836319 4.830270 0.0000014 0.0000194
TACR2 22.50443 3.413183 0.8263940 4.130212 0.0000362 0.0003689
RELN 59.60546 3.360670 0.5577914 6.024958 0.0000000 0.0000000
CXCL10 30.44420 3.358956 0.7735191 4.342434 0.0000141 0.0001487
FOS 99.81080 3.018476 0.7409628 4.073722 0.0000463 0.0004121
NR5A1 21.70636 2.930980 0.7698789 3.807066 0.0001406 0.0010547
CREBBP 507.81195 -2.841111 0.3708323 -7.661446 0.0000000 0.0000000
GAD2 1102.90336 2.829517 0.4200353 6.736378 0.0000000 0.0000000
IGF1 87.00903 2.663510 0.5148849 5.173020 0.0000002 0.0000041
TYROBP 32.84460 -2.662689 0.5688121 -4.681140 0.0000029 0.0000358
THEMIS 18.90166 -2.653675 0.7208571 -3.681278 0.0002321 0.0015747
CDH7 31.11840 -2.612299 0.5583383 -4.678703 0.0000029 0.0000358
DCN 18.23625 2.552677 0.8008191 3.187583 0.0014347 0.0071734
ANPEP 13.54895 2.537239 0.8806702 2.881032 0.0039638 0.0170699
MAP4K3 105.30297 2.530594 0.4327472 5.847742 0.0000000 0.0000001
GRIN3B 23.50741 2.522269 0.7645883 3.298858 0.0009708 0.0051236
SNCA 113.44519 2.508350 0.4062737 6.174040 0.0000000 0.0000000
MAPK1 242.12448 2.479500 0.3777529 6.563815 0.0000000 0.0000000
NRG3 93.93860 2.387923 0.4716222 5.063212 0.0000004 0.0000069
CD74 204.58663 -2.354216 0.6077897 -3.873405 0.0001073 0.0008497
CX3CL1 369.23705 -2.334052 0.3539969 -6.593424 0.0000000 0.0000000
CTSS 13.49475 2.317963 0.8578125 2.702179 0.0068887 0.0272676
HTR1A 25.36167 -2.284446 0.5951186 -3.838639 0.0001237 0.0009530
NR2F2 22.63017 2.272949 0.6861102 3.312804 0.0009237 0.0049668
MTOR 102.57845 2.217730 0.4414149 5.024140 0.0000005 0.0000080
PCP4 20.27643 2.146293 0.7459800 2.877145 0.0040129 0.0170699
MRC2 31.89783 -2.102320 0.5272037 -3.987681 0.0000667 0.0005762
FEZF2 33.89373 -2.099503 0.5141869 -4.083151 0.0000444 0.0004085
MEIS2 40.71285 2.079228 0.5711160 3.640641 0.0002720 0.0018025
CRH 256.59403 1.961337 0.3501473 5.601463 0.0000000 0.0000004
NDNF 21.62800 1.948311 0.7698746 2.530686 0.0113840 0.0381698
PTEN 65.98544 1.939160 0.6889743 2.814560 0.0048844 0.0204714
ROS1 38.51084 1.931501 0.5513272 3.503365 0.0004594 0.0027278
SLC6A4 15.90521 -1.827669 0.7197554 -2.539292 0.0111077 0.0380869
VIP 19.02378 -1.824506 0.6929924 -2.632793 0.0084686 0.0313448
CSF1 98.82874 -1.793774 0.3947327 -4.544274 0.0000055 0.0000638
OLIG1 48.58792 1.730394 0.5097962 3.394285 0.0006881 0.0038451
TAC1 44.43273 1.726078 0.5486058 3.146299 0.0016535 0.0081250
NPTX2 70.78832 -1.701576 0.5621251 -3.027041 0.0024696 0.0117306
BMP2 30.77655 1.617481 0.6636263 2.437337 0.0147959 0.0473801
ACE 84.87622 -1.613050 0.4486660 -3.595213 0.0003241 0.0020528
SCIMP 21.06039 -1.609930 0.6179832 -2.605135 0.0091838 0.0331314
NPY1R 29.98448 1.602147 0.6592422 2.430286 0.0150869 0.0477753
FERMT2 31.79604 1.592866 0.5730060 2.779841 0.0054386 0.0221427
DBH 20.54408 -1.560379 0.6282537 -2.483677 0.0130034 0.0425972
NOS1 930.22462 -1.518226 0.3343210 -4.541220 0.0000056 0.0000638
HS3ST1 65.86712 -1.475456 0.5020679 -2.938759 0.0032953 0.0149073
CAMK2G 1653.00934 -1.460137 0.2921304 -4.998236 0.0000006 0.0000087
RIMS2 115.43811 1.446576 0.3875890 3.732242 0.0001898 0.0013522
PLAGL1 350.29694 1.424927 0.3233255 4.407098 0.0000105 0.0001148
CALB1 91.70097 1.407427 0.5057603 2.782795 0.0053893 0.0221427
KCNC1 1204.50196 -1.396505 0.3592428 -3.887357 0.0001013 0.0008252
TSHZ1 198.12277 -1.385189 0.3650391 -3.794632 0.0001479 0.0010805
SULF2 97.63252 -1.354356 0.3901672 -3.471221 0.0005181 0.0030134
SNCG 135.65151 -1.319280 0.3686503 -3.578675 0.0003453 0.0021396
CHRM4 125.72639 -1.314264 0.3624226 -3.626330 0.0002875 0.0018621
ROBO1 70.07068 1.279842 0.5236144 2.444245 0.0145156 0.0470106
PRKCD 451.83356 -1.268693 0.3086708 -4.110181 0.0000395 0.0003885
PILRA 70.55395 1.253375 0.4723557 2.653455 0.0079672 0.0298771
SLC29A2 85.74191 1.249480 0.4636200 2.695052 0.0070378 0.0274762
LHX6 404.57837 -1.246277 0.3359052 -3.710205 0.0002071 0.0014395
SYN1 2183.05373 -1.242016 0.3727328 -3.332188 0.0008617 0.0047226
NEGR1 101.48352 1.205174 0.3960168 3.043241 0.0023405 0.0113056
ADGRA1 356.79231 -1.204740 0.3736055 -3.224633 0.0012613 0.0064193
SYNGAP1 1147.91574 -1.186637 0.3351691 -3.540414 0.0003995 0.0024225
BACE1 714.96460 -1.174882 0.2876651 -4.084203 0.0000442 0.0004085
SORL1 523.11534 -1.169482 0.3003199 -3.894120 0.0000986 0.0008252
PTK2B 129.12849 -1.133259 0.4269624 -2.654236 0.0079488 0.0298771
SLC17A7 186.09545 -1.129639 0.3856825 -2.928936 0.0034012 0.0151461
CCKBR 150.34240 -1.123058 0.3770620 -2.978444 0.0028972 0.0135359
ETV1 207.17084 1.106480 0.4222570 2.620396 0.0087828 0.0320909
GRIA3 1321.49200 -1.087148 0.3190839 -3.407093 0.0006566 0.0037426
UBE3A 154.48111 1.068845 0.3617520 2.954636 0.0031304 0.0143897
PRSS12 374.13120 -1.032530 0.3872633 -2.666222 0.0076709 0.0295433
SLC32A1 1122.28383 1.021677 0.4029336 2.535596 0.0112256 0.0380869

6.9 Microglia

X baseMean log2FoldChange lfcSE stat pvalue padj
GRM5 230.07275 5.459006 0.4909126 11.120119 0.0000000 0.0000000
DLG4 877.56313 5.289647 0.3621794 14.605047 0.0000000 0.0000000
GRIA4 184.09496 5.225674 0.5184348 10.079713 0.0000000 0.0000000
IFNG 633.52031 4.660607 0.4295268 10.850561 0.0000000 0.0000000
CXCL10 80.95386 4.564888 0.8196777 5.569126 0.0000000 0.0000004
CREBBP 2864.71193 -4.080077 0.3115102 -13.097730 0.0000000 0.0000000
CTSS 413.07436 3.655102 0.3706592 9.861084 0.0000000 0.0000000
CDH7 230.81515 -3.314586 0.3821789 -8.672866 0.0000000 0.0000000
CHODL 229.04538 3.297434 0.7716301 4.273335 0.0000193 0.0001425
MKI67 108.50154 3.210188 0.6881419 4.665009 0.0000031 0.0000269
NR5A1 89.93129 3.190311 0.4784111 6.668555 0.0000000 0.0000000
SNCA 550.65051 3.087846 0.3456062 8.934579 0.0000000 0.0000000
GPHN 156.96599 3.083974 0.3902375 7.902812 0.0000000 0.0000000
P2RY12 2822.98823 3.060851 0.5560475 5.504658 0.0000000 0.0000005
SCTR 38.93731 2.902379 0.5997784 4.839086 0.0000013 0.0000121
IGF1 141.25750 2.794564 0.4749579 5.883814 0.0000000 0.0000001
GRIN3B 59.35139 2.777159 0.5598645 4.960413 0.0000007 0.0000067
FLT1 145.85457 2.695626 0.4078074 6.610046 0.0000000 0.0000000
RIMS1 204.24782 2.590504 0.4298610 6.026376 0.0000000 0.0000000
IYD 188.04919 -2.589560 0.3469674 -7.463410 0.0000000 0.0000000
SEMA5B 314.73910 2.547877 0.7132392 3.572262 0.0003539 0.0017173
KCNQ1 2595.54869 -2.477251 0.4717625 -5.251055 0.0000002 0.0000017
MS4A7 1092.95532 2.443028 0.4526174 5.397556 0.0000001 0.0000009
MAPK1 767.50167 2.422809 0.4138398 5.854462 0.0000000 0.0000001
MEIS2 115.11503 2.370583 0.4028679 5.884269 0.0000000 0.0000001
DCN 112.40523 2.309712 0.5125293 4.506498 0.0000066 0.0000527
NEGR1 172.37069 2.290404 0.4579212 5.001743 0.0000006 0.0000056
SYT6 2906.14392 -2.270066 0.5559090 -4.083520 0.0000444 0.0003054
RIMS2 129.90256 2.248913 0.4479255 5.020729 0.0000005 0.0000053
TLR4 392.47603 2.189916 0.5802674 3.773978 0.0001607 0.0008807
PRKCD 7381.29905 -2.172173 0.3943681 -5.507983 0.0000000 0.0000005
SIM1 75.38409 2.126910 0.5928340 3.587699 0.0003336 0.0016458
CHRNA5 25.59215 2.097813 0.5985993 3.504537 0.0004574 0.0020829
PTEN 134.50910 2.087615 0.5583080 3.739182 0.0001846 0.0009882
MRC2 5299.43821 -2.077615 0.3910417 -5.313028 0.0000001 0.0000013
TNF 401.51972 1.995994 0.6437400 3.100622 0.0019311 0.0068050
TRHR 26.33168 1.977349 0.5623751 3.516067 0.0004380 0.0020579
MTOR 201.83040 1.973278 0.3752644 5.258368 0.0000001 0.0000017
THEMIS 77.15026 -1.957863 0.3774014 -5.187746 0.0000002 0.0000023
IL1B 725.56095 1.948049 0.7222093 2.697347 0.0069894 0.0189353
FEZF2 201.36637 -1.885076 0.3342079 -5.640429 0.0000000 0.0000003
ADAM10 115.16276 1.856704 0.6839759 2.714576 0.0066361 0.0185309
KCTD4 28.93073 1.848521 0.6030772 3.065148 0.0021756 0.0074882
CD74 85493.15089 -1.836366 0.4691054 -3.914614 0.0000905 0.0005361
CACNG5 51.42828 1.831370 0.4677768 3.915052 0.0000904 0.0005361
TREM2 4321.92053 -1.797892 0.2910026 -6.178267 0.0000000 0.0000000
ANPEP 25.60691 1.789627 0.5671291 3.155590 0.0016017 0.0058033
PCP4 32.17738 1.778993 0.5539027 3.211742 0.0013193 0.0050067
CHAT 33.29722 -1.776300 0.4468857 -3.974841 0.0000704 0.0004632
INPP5D 12585.52766 -1.773066 0.3839976 -4.617389 0.0000039 0.0000329
NOS1 143.16811 -1.770725 0.4143445 -4.273558 0.0000192 0.0001425
NTF3 17.12858 1.760495 0.6532207 2.695099 0.0070368 0.0189353
SPI1 7814.25818 -1.750942 0.5016719 -3.490212 0.0004826 0.0021646
PKP2 26.00963 1.749971 0.5935253 2.948435 0.0031939 0.0100573
OLIG1 269.80540 1.745326 0.3793109 4.601307 0.0000042 0.0000345
NPNT 63.61753 1.735930 0.4417724 3.929467 0.0000851 0.0005250
PDYN 107.06027 -1.733119 0.4392424 -3.945701 0.0000796 0.0005120
RSPO1 20.30822 -1.705764 0.5251530 -3.248128 0.0011617 0.0045108
FEV 127.24587 -1.689931 0.4108969 -4.112786 0.0000391 0.0002755
TLX3 26.33513 -1.679445 0.6597250 -2.545674 0.0109067 0.0262470
GAD2 57.89901 1.670751 0.5590531 2.988538 0.0028032 0.0091180
HTR1F 21.19517 1.668193 0.5940292 2.808268 0.0049809 0.0147434
NR2F2 67.97435 1.656230 0.4593293 3.605757 0.0003112 0.0015615
CX3CL1 316.21592 -1.639973 0.3037137 -5.399735 0.0000001 0.0000009
SHARPIN 518.08336 -1.567620 0.4449355 -3.523252 0.0004263 0.0020352
NRG3 111.73524 1.561596 0.4532611 3.445245 0.0005705 0.0024475
CHRNA7 27.08965 1.547892 0.5963850 2.595458 0.0094465 0.0234972
CELSR1 71.53484 1.545743 0.4088884 3.780354 0.0001566 0.0008746
MAS1 66.55138 -1.544764 0.4649290 -3.322580 0.0008919 0.0036667
DEPTOR 2105.03210 -1.521521 0.3410730 -4.460984 0.0000082 0.0000635
MUSK 22.40233 -1.497600 0.4980886 -3.006695 0.0026410 0.0087837
CAMK2G 1843.57127 -1.484405 0.2915664 -5.091139 0.0000004 0.0000038
FOXP2 88.55209 1.462528 0.4910078 2.978625 0.0028955 0.0093158
NOSTRIN 104.03619 -1.443439 0.4720673 -3.057698 0.0022304 0.0075886
LAMP5 348.52788 1.420345 0.3354464 4.234193 0.0000229 0.0001656
BMP2 22.40017 1.415789 0.5470370 2.588105 0.0096505 0.0238047
IL10 33.85017 1.408730 0.5710490 2.466917 0.0136282 0.0315152
TH 38.89304 -1.405761 0.4436981 -3.168283 0.0015334 0.0056737
FERMT2 92.61500 1.400773 0.4316365 3.245262 0.0011734 0.0045108
BACE1 956.17119 -1.394616 0.3540690 -3.938826 0.0000819 0.0005157
SORL1 17899.70567 -1.394029 0.2945608 -4.732568 0.0000022 0.0000199
BIN1 10779.71654 -1.381952 0.4648792 -2.972713 0.0029518 0.0093950
NPY1R 66.46961 1.349436 0.4756929 2.836781 0.0045571 0.0137643
TACR2 27.25122 1.334985 0.5117175 2.608831 0.0090852 0.0230365
NOS3 101.81577 1.332839 0.4026767 3.309949 0.0009331 0.0037836
CAMK2A 1675.01507 1.325240 0.3775955 3.509681 0.0004486 0.0020750
WNT2 18.86221 1.324573 0.5600011 2.365304 0.0180153 0.0392097
HTR3A 27.01440 -1.309664 0.4830334 -2.711332 0.0067014 0.0185383
ABI3 2699.24468 -1.308722 0.3771086 -3.470410 0.0005197 0.0022621
TRPM4 809.40668 -1.284829 0.4041497 -3.179091 0.0014774 0.0055355
MAP4K3 265.01331 1.284377 0.3378384 3.801749 0.0001437 0.0008179
ROS1 53.00405 1.266027 0.4229033 2.993656 0.0027566 0.0090660
SCIMP 215.18149 -1.249585 0.3089250 -4.044946 0.0000523 0.0003521
COL11A1 65.29318 1.247800 0.4106177 3.038836 0.0023749 0.0079884
NPTX1 349.94626 1.243254 0.3327755 3.736016 0.0001870 0.0009882
GRIA2 807.84268 1.226027 0.3390434 3.616135 0.0002990 0.0015529
CALB2 73.57797 1.217971 0.3968495 3.069101 0.0021470 0.0074768
CD79A 45.18247 -1.212063 0.4647370 -2.608061 0.0091057 0.0230365
PTK2B 1876.34169 -1.205223 0.3146175 -3.830755 0.0001278 0.0007415
SLC6A4 24.02360 -1.205089 0.4920519 -2.449109 0.0143210 0.0326078
NGF 41.45567 -1.187783 0.4390161 -2.705557 0.0068190 0.0186891
CD8A 95.60468 -1.160322 0.4264115 -2.721132 0.0065059 0.0184398
DRD2 34.58097 -1.150992 0.4232608 -2.719345 0.0065411 0.0184398
ADAM17 1111.84516 -1.136260 0.3624972 -3.134535 0.0017213 0.0061385
SYNGAP1 1484.04508 -1.132557 0.3262058 -3.471909 0.0005168 0.0022621
FOS 3483.21571 1.128845 0.4482940 2.518092 0.0117993 0.0278863
MINK1 3415.08402 -1.101623 0.3901580 -2.823532 0.0047498 0.0142013
RELN 49.27938 1.098168 0.4482332 2.449993 0.0142859 0.0326078
DBH 28.58925 -1.096729 0.4624973 -2.371320 0.0177247 0.0388629
ITGA7 282.06860 -1.069476 0.3659788 -2.922236 0.0034753 0.0107962
RBP4 511.25626 1.057588 0.2931008 3.608273 0.0003082 0.0015615
ERBB2 162.71875 -1.055268 0.4528468 -2.330298 0.0197904 0.0424489
HLA-DMB 1502.05856 -1.051327 0.3097497 -3.394116 0.0006885 0.0029114
TSHZ1 348.31452 -1.044590 0.3209146 -3.255040 0.0011338 0.0044746
C1QA 4364.33412 -1.040175 0.3121085 -3.332735 0.0008600 0.0035852
SYN1 2054.46692 -1.030604 0.4029999 -2.557330 0.0105479 0.0255917
PSEN2 487.34452 -1.030045 0.3265309 -3.154510 0.0016077 0.0058033
HS3ST1 92.97866 -1.011369 0.3545981 -2.852156 0.0043424 0.0132510
SOX10 930.18713 -1.007355 0.3678951 -2.738158 0.0061784 0.0177555

6.10 Oligo

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 890.51003 5.147318 0.5468405 9.412833 0.0000000 0.0000000
GRIA4 1054.90078 5.135536 0.3481122 14.752531 0.0000000 0.0000000
DLG4 2152.70602 4.371352 0.2306683 18.950813 0.0000000 0.0000000
GPHN 1192.97433 4.327927 0.3956237 10.939504 0.0000000 0.0000000
CA12 346.11966 -4.236190 0.3983917 -10.633227 0.0000000 0.0000000
TLX3 1075.51694 -4.103208 0.4571430 -8.975766 0.0000000 0.0000000
NOSTRIN 1525.66062 -4.046916 0.3802661 -10.642328 0.0000000 0.0000000
CDH7 1111.32748 -3.994923 0.2861127 -13.962762 0.0000000 0.0000000
NMBR 607.05935 -3.947066 0.2378154 -16.597184 0.0000000 0.0000000
GRM5 524.53213 3.664903 0.2925434 12.527723 0.0000000 0.0000000
NR5A1 289.57390 3.217098 0.3105306 10.360002 0.0000000 0.0000000
TEK 1347.78047 -3.178170 0.2310654 -13.754418 0.0000000 0.0000000
RSPO1 227.19795 -3.134258 0.3548045 -8.833761 0.0000000 0.0000000
SST 1143.35866 -3.088000 0.5016566 -6.155606 0.0000000 0.0000000
CREBBP 5379.80705 -3.085051 0.2756171 -11.193251 0.0000000 0.0000000
MAPK1 2414.33923 3.049196 0.2957179 10.311164 0.0000000 0.0000000
PTEN 438.15513 2.983045 0.3897466 7.653806 0.0000000 0.0000000
GRIN3B 216.08835 2.859617 0.5044156 5.669168 0.0000000 0.0000001
SCTR 58.99333 2.772649 0.4087328 6.783525 0.0000000 0.0000000
DRD2 348.67641 -2.769746 0.2911371 -9.513546 0.0000000 0.0000000
NPTX2 3207.40072 -2.691791 0.4005568 -6.720124 0.0000000 0.0000000
IL10 86.57165 2.541261 0.4259525 5.966065 0.0000000 0.0000000
MKI67 252.04181 2.526032 0.6503930 3.883855 0.0001028 0.0003711
CACNG5 535.26386 2.519343 0.3048761 8.263498 0.0000000 0.0000000
MEIS2 1218.69084 2.457311 0.2510933 9.786445 0.0000000 0.0000000
CD8A 227.02668 -2.400592 0.3389862 -7.081682 0.0000000 0.0000000
SCIMP 286.44546 -2.376634 0.2456495 -9.674899 0.0000000 0.0000000
ADRB1 194.60939 2.344471 0.3219515 7.282062 0.0000000 0.0000000
SNCA 2481.32451 2.341087 0.2272873 10.300119 0.0000000 0.0000000
ITGAL 396.98466 -2.290565 0.3968028 -5.772552 0.0000000 0.0000001
FEZF2 917.57696 -2.246346 0.2910121 -7.719080 0.0000000 0.0000000
SPI1 366.44102 -2.242811 0.5567874 -4.028129 0.0000562 0.0002055
KCNQ1 193.08891 -2.227148 0.2866548 -7.769442 0.0000000 0.0000000
GLP2R 394.20190 -2.219191 0.3505637 -6.330352 0.0000000 0.0000000
NPTX1 893.90817 2.158772 0.3134500 6.887133 0.0000000 0.0000000
NEGR1 657.79333 2.070183 0.4412992 4.691111 0.0000027 0.0000126
CD19 170.81685 -2.047098 0.2939615 -6.963832 0.0000000 0.0000000
LAMP5 763.37328 2.024019 0.3690883 5.483835 0.0000000 0.0000003
OLIG1 10480.86919 2.020023 0.2954422 6.837286 0.0000000 0.0000000
TH 216.34655 -1.977499 0.3631112 -5.445987 0.0000001 0.0000003
NDNF 199.25392 -1.951244 0.3020615 -6.459759 0.0000000 0.0000000
MS4A4A 231.96319 1.905008 0.3009035 6.330959 0.0000000 0.0000000
CHODL 440.11992 1.859641 0.7323582 2.539251 0.0111090 0.0234876
BDKRB1 199.85193 -1.832304 0.4157847 -4.406859 0.0000105 0.0000431
DBH 101.97588 -1.808009 0.3518088 -5.139182 0.0000003 0.0000016
RIMS2 384.64767 1.804002 0.2963586 6.087228 0.0000000 0.0000000
CHAT 95.32738 -1.789711 0.2976787 -6.012224 0.0000000 0.0000000
TSHR 100.12408 -1.766129 0.4551137 -3.880633 0.0001042 0.0003716
VTN 291.67360 -1.759079 0.3516914 -5.001770 0.0000006 0.0000029
NPY1R 157.22551 1.738180 0.3437889 5.055952 0.0000004 0.0000023
ICAM1 117.10338 -1.737736 0.3098465 -5.608375 0.0000000 0.0000001
RELN 190.13397 1.724539 0.4553519 3.787266 0.0001523 0.0005123
KCTD4 403.55337 1.709085 0.5513925 3.099579 0.0019380 0.0048205
SLCO2A1 75.67406 1.685145 0.3439662 4.899157 0.0000010 0.0000046
NOS3 200.16863 1.673834 0.3411887 4.905890 0.0000009 0.0000045
NDST4 87.74352 -1.661201 0.5249942 -3.164227 0.0015550 0.0039678
CAMK2A 3054.34272 1.660383 0.1949352 8.517616 0.0000000 0.0000000
LCN2 147.45123 -1.636668 0.4357654 -3.755846 0.0001728 0.0005689
CSN1S1 112.82325 1.618219 0.3015694 5.365993 0.0000001 0.0000005
CTSS 73.91481 1.606906 0.3139442 5.118444 0.0000003 0.0000017
CD74 4245.94092 -1.604606 0.4370753 -3.671236 0.0002414 0.0007766
COCH 217.03674 -1.593067 0.2983586 -5.339436 0.0000001 0.0000006
CD79A 170.40307 -1.579914 0.3193055 -4.947969 0.0000007 0.0000038
CST7 93.62283 -1.572472 0.3530986 -4.453353 0.0000085 0.0000357
P2RY12 225.30021 1.567109 0.3672285 4.267396 0.0000198 0.0000791
ACE 168.67012 -1.545578 0.2712842 -5.697265 0.0000000 0.0000001
PRF1 104.19843 1.543391 0.3786872 4.075636 0.0000459 0.0001719
SYT6 229.76250 -1.533369 0.6231150 -2.460812 0.0138623 0.0277001
FIBCD1 257.45456 1.531772 0.3039326 5.039840 0.0000005 0.0000025
SLC6A4 213.29426 -1.522407 0.5090301 -2.990800 0.0027825 0.0068067
TACR2 95.46000 1.509979 0.4020693 3.755518 0.0001730 0.0005689
LMNA 5213.54881 1.507799 0.3660019 4.119648 0.0000379 0.0001459
IL1B 213.89130 -1.507027 0.4509226 -3.342097 0.0008315 0.0022716
SIM1 94.29541 1.502098 0.3378794 4.445661 0.0000088 0.0000365
CASP8 185.35085 -1.489660 0.3031537 -4.913877 0.0000009 0.0000044
FOXP2 184.77249 -1.485031 0.3874410 -3.832922 0.0001266 0.0004308
CRH 194.53025 1.444694 0.2756036 5.241926 0.0000002 0.0000009
TREM2 160.41495 -1.421849 0.4179859 -3.401667 0.0006698 0.0019062
NOS1 1330.00430 -1.409801 0.2839672 -4.964660 0.0000007 0.0000035
NGF 145.23912 -1.394932 0.4851841 -2.875057 0.0040395 0.0094897
VIPR2 82.68162 -1.393712 0.2924939 -4.764928 0.0000019 0.0000089
DCN 234.15537 1.390737 0.3725019 3.733501 0.0001888 0.0006142
VIP 127.44069 -1.365062 0.3543302 -3.852515 0.0001169 0.0004043
INPP5D 604.38083 -1.358126 0.2942961 -4.614827 0.0000039 0.0000174
SLC30A3 474.56112 1.351389 0.3019388 4.475705 0.0000076 0.0000327
CALB1 370.56823 -1.342845 0.3980685 -3.373402 0.0007425 0.0020584
SLC14A1 176.83705 -1.339693 0.4233434 -3.164553 0.0015532 0.0039678
TAC1 81.15155 1.332840 0.3770528 3.534888 0.0004079 0.0012421
LYNX1 4076.50471 1.330146 0.4394105 3.027116 0.0024690 0.0060902
FERMT2 1273.35368 1.283969 0.3034528 4.231197 0.0000232 0.0000917
NTS 40.51443 -1.278562 0.4113327 -3.108341 0.0018814 0.0047195
KCNH7 173.77802 1.265881 0.4288104 2.952076 0.0031565 0.0075348
CTNNA3 1622.40890 1.256367 0.3503557 3.585975 0.0003358 0.0010463
CD4 233.83689 -1.248084 0.3771633 -3.309134 0.0009358 0.0025142
NR2F2 174.02060 1.245551 0.4289637 2.903629 0.0036887 0.0087347
TLR4 322.86765 1.241958 0.4983206 2.492288 0.0126923 0.0259098
RIMS1 847.79282 1.217838 0.3487323 3.492186 0.0004791 0.0013903
VCAM1 130.68294 -1.215418 0.3445621 -3.527428 0.0004196 0.0012421
NPAS1 165.90832 -1.213169 0.3631779 -3.340426 0.0008365 0.0022716
HTR1F 97.63981 1.206115 0.3130234 3.853116 0.0001166 0.0004043
EPHA1 214.70453 -1.198127 0.4750007 -2.522368 0.0116568 0.0242986
ANPEP 59.85618 1.194125 0.3382720 3.530074 0.0004154 0.0012421
DRD1 377.22258 -1.192458 0.4012624 -2.971766 0.0029609 0.0071255
IL1RAPL2 209.18278 -1.192318 0.2544087 -4.686625 0.0000028 0.0000126
BACE1 21930.40975 -1.189329 0.1576598 -7.543646 0.0000000 0.0000000
LCT 133.37366 -1.170546 0.5044956 -2.320231 0.0203284 0.0391525
CPLX1 1060.40193 1.162271 0.3180724 3.654109 0.0002581 0.0008214
CX3CL1 670.03715 -1.160733 0.4635395 -2.504066 0.0122775 0.0254136
NPTXR 2708.20249 1.137371 0.2094523 5.430217 0.0000001 0.0000004
DKK3 1763.95920 1.128756 0.5046817 2.236570 0.0253144 0.0477266
TBX1 62.65357 -1.128135 0.4717259 -2.391505 0.0167795 0.0331115
AQP4 1367.62257 1.126596 0.4323478 2.605762 0.0091670 0.0202495
GPC3 85.21457 1.114139 0.3575293 3.116218 0.0018319 0.0046345
LHX6 236.41318 -1.106612 0.2459071 -4.500123 0.0000068 0.0000296
CSF1 3182.54468 -1.084004 0.2138840 -5.068184 0.0000004 0.0000022
UBE3A 1951.82964 1.072671 0.2654602 4.040798 0.0000533 0.0001971
SOX10 51888.56725 -1.060431 0.2297806 -4.614974 0.0000039 0.0000174
CDH12 227.98529 1.057569 0.4526999 2.336137 0.0194841 0.0381940
HRH3 182.03507 1.046110 0.2512592 4.163470 0.0000313 0.0001221
ERBB2 634.32555 -1.043168 0.2893530 -3.605174 0.0003119 0.0009823
NTF3 42.90339 1.042940 0.4230142 2.465496 0.0136824 0.0275509
THEMIS 413.28188 -1.041497 0.3156691 -3.299330 0.0009692 0.0025387
PCP4 79.51484 1.022681 0.4043833 2.528989 0.0114392 0.0240141
CALB2 239.71583 -1.017662 0.2480548 -4.102570 0.0000409 0.0001551

6.11 OPC

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 2646.39869 8.209118 0.8444219 9.721583 0.0000000 0.0000000
CHODL 3679.78755 7.717214 1.0034196 7.690914 0.0000000 0.0000000
SCTR 795.52748 6.959238 0.9272589 7.505172 0.0000000 0.0000000
NOS3 714.67825 6.278041 0.9065428 6.925256 0.0000000 0.0000000
CXCL10 949.99190 5.796814 0.8896339 6.515954 0.0000000 0.0000000
GRM5 708.89040 5.752588 0.5524692 10.412505 0.0000000 0.0000000
SIM1 783.27058 5.674027 0.9300512 6.100769 0.0000000 0.0000000
GPHN 328.96899 5.264201 0.5195050 10.133110 0.0000000 0.0000000
GRIA4 843.49921 5.148130 0.4308721 11.948163 0.0000000 0.0000000
MKI67 517.20853 3.844398 0.9650859 3.983478 0.0000679 0.0003866
RIMS1 375.31542 3.835695 0.3971868 9.657157 0.0000000 0.0000000
CREBBP 2430.53739 -3.760867 0.3123121 -12.042013 0.0000000 0.0000000
DLG4 978.85744 3.673178 0.3878506 9.470600 0.0000000 0.0000000
PTEN 168.49359 3.548889 0.5446862 6.515474 0.0000000 0.0000000
SNCA 581.68555 3.283767 0.4095703 8.017589 0.0000000 0.0000000
DCN 86.61256 3.181678 0.5903909 5.389103 0.0000001 0.0000009
P2RY12 83.66889 3.142226 0.6247671 5.029436 0.0000005 0.0000056
GRIN3B 51.55796 3.117259 0.5602081 5.564467 0.0000000 0.0000004
IGF2 471.44546 3.069887 0.7700141 3.986794 0.0000670 0.0003866
CTSS 25.73341 2.687093 0.6233170 4.310957 0.0000163 0.0001174
IL10 25.17112 2.468721 0.6776161 3.643244 0.0002692 0.0012111
WNT2 23.64781 2.462295 0.5950047 4.138278 0.0000350 0.0002228
OPALIN 1635.05197 2.438850 0.4951024 4.925951 0.0000008 0.0000086
MEIS2 401.08554 2.396952 0.3395427 7.059354 0.0000000 0.0000000
ROS1 73.16922 2.396772 0.5689789 4.212409 0.0000253 0.0001739
GPR37 1209.08755 2.306285 0.6915274 3.335060 0.0008528 0.0031953
MAPK1 820.16806 2.273436 0.4060713 5.598612 0.0000000 0.0000003
SYT6 491.38059 -2.241480 0.4560954 -4.914499 0.0000009 0.0000088
SEMA5B 4613.78979 2.231395 0.8837081 2.525036 0.0115686 0.0305743
ADGRA1 2908.09021 -2.220719 0.3558490 -6.240620 0.0000000 0.0000000
MAP4K3 526.70223 2.215688 0.4058325 5.459611 0.0000000 0.0000006
CTNNA3 83.73439 2.181673 0.5632525 3.873347 0.0001074 0.0005479
VIPR2 591.40514 -2.140043 0.4439278 -4.820701 0.0000014 0.0000128
DRD2 82.25944 -2.130759 0.4277212 -4.981653 0.0000006 0.0000069
CX3CL1 787.02421 -2.100342 0.2974945 -7.060102 0.0000000 0.0000000
GPR15 32.57194 2.091399 0.7128699 2.933774 0.0033487 0.0107740
IL1B 56.38239 2.084119 0.8274443 2.518743 0.0117775 0.0308507
CHRNA5 43.23901 2.054906 0.4765996 4.311599 0.0000162 0.0001174
NRG3 187.56024 2.045019 0.4367518 4.682336 0.0000028 0.0000233
FLT1 105.66661 2.037967 0.5595034 3.642458 0.0002700 0.0012111
PKP2 153.64921 -2.037171 0.7528339 -2.706004 0.0068098 0.0201571
PCP4 43.03596 2.030995 0.5064011 4.010644 0.0000606 0.0003585
TACR2 33.62399 2.030356 0.6199157 3.275213 0.0010558 0.0038113
MRC2 384.58451 -1.956981 0.3768879 -5.192475 0.0000002 0.0000026
NEGR1 348.52699 1.956632 0.4156765 4.707103 0.0000025 0.0000212
MS4A7 35.43110 1.949684 0.4993011 3.904826 0.0000943 0.0005144
NOS1 1916.03779 -1.945642 0.5748550 -3.384578 0.0007129 0.0028135
SLC32A1 162.55765 1.879921 0.5532049 3.398236 0.0006782 0.0027500
NPY1R 61.12406 1.858171 0.5295397 3.509031 0.0004497 0.0019293
MTOR 292.05012 1.827141 0.3800195 4.808018 0.0000015 0.0000133
CASS4 40.29007 1.817250 0.5418880 3.353552 0.0007978 0.0030669
ADAM10 75.80030 1.807394 0.6965720 2.594698 0.0094674 0.0257097
RBP4 652.18025 1.806149 0.7305212 2.472412 0.0134205 0.0342454
HTR1A 101.30243 -1.806064 0.3905599 -4.624294 0.0000038 0.0000293
NPNT 76.66470 1.802460 0.4058715 4.440963 0.0000090 0.0000680
CAMK2G 2718.24745 -1.784092 0.2867279 -6.222247 0.0000000 0.0000000
ECHDC3 193.59958 1.778862 0.6942194 2.562391 0.0103954 0.0279731
TLR4 91.91373 1.773629 0.4574177 3.877483 0.0001055 0.0005479
GAD1 3076.83397 -1.773290 0.5248245 -3.378824 0.0007280 0.0028352
NR5A1 243.56968 1.766365 0.6915136 2.554346 0.0106387 0.0283700
KCND2 2650.00839 -1.749615 0.2767826 -6.321262 0.0000000 0.0000000
TAC1 54.31582 1.747133 0.5008138 3.488588 0.0004856 0.0020533
CSF1 682.50301 -1.743912 0.4469791 -3.901553 0.0000956 0.0005144
CASP8 37.86643 1.715401 0.7068178 2.426935 0.0152270 0.0378756
TRPM4 407.45820 -1.714102 0.4144562 -4.135786 0.0000354 0.0002228
HS3ST1 316.33960 -1.675542 0.3393394 -4.937659 0.0000008 0.0000084
FEZF2 215.61677 -1.657001 0.3251106 -5.096729 0.0000003 0.0000041
CRH 51.69758 1.650229 0.6175947 2.672025 0.0075395 0.0216669
ADGRG7 22.78942 1.645663 0.5328670 3.088319 0.0020129 0.0068486
KCNC1 901.88200 -1.641222 0.5132188 -3.197899 0.0013843 0.0048781
NGF 184.49945 -1.623310 0.3804626 -4.266673 0.0000198 0.0001398
CSPG4 3829.55162 -1.612988 0.4016747 -4.015657 0.0000593 0.0003581
TSHZ1 1377.55355 -1.590965 0.3273676 -4.859875 0.0000012 0.0000109
ANPEP 19.67696 1.576318 0.5739809 2.746290 0.0060273 0.0182050
CD74 1575.11013 -1.574058 0.4169632 -3.775053 0.0001600 0.0007637
SPI1 130.73557 -1.552228 0.4272658 -3.632932 0.0002802 0.0012380
NPTX1 382.08252 1.521193 0.4067124 3.740218 0.0001839 0.0008639
ALDH1L1 1273.82258 -1.517065 0.4478830 -3.387192 0.0007061 0.0028135
FGFR3 4288.55722 -1.512768 0.5675940 -2.665230 0.0076936 0.0218971
RIMS2 318.06786 1.511422 0.3637197 4.155459 0.0000325 0.0002135
NPTX2 647.82551 -1.505661 0.4323268 -3.482692 0.0004964 0.0020695
RSPO1 29.64732 -1.504786 0.6220621 -2.419029 0.0155620 0.0380690
PDGFRB 496.71636 -1.504669 0.3084570 -4.878051 0.0000011 0.0000102
FIBCD1 58.02848 1.492466 0.4501973 3.315139 0.0009160 0.0033473
SOX10 13881.84778 -1.465822 0.4530988 -3.235104 0.0012160 0.0043365
AGTR1 17.11944 1.449630 0.6105093 2.374460 0.0175747 0.0414106
CELSR1 94.62744 1.444878 0.3820260 3.782145 0.0001555 0.0007545
BCL11B 258.36168 -1.437838 0.3692453 -3.893990 0.0000986 0.0005212
AQP4 395.10572 1.419185 0.5309098 2.673119 0.0075150 0.0216669
MS4A4A 41.15761 1.405077 0.5916586 2.374811 0.0175580 0.0414106
GAD2 59.05761 1.398507 0.4390713 3.185148 0.0014468 0.0049797
CRTAC1 2354.47094 -1.394266 0.3339526 -4.175042 0.0000298 0.0002004
SULF2 5546.23315 -1.385946 0.3378921 -4.101743 0.0000410 0.0002529
SYN1 2939.55485 -1.371502 0.3903040 -3.513934 0.0004415 0.0019219
KCNQ1 52.67243 -1.362478 0.4519022 -3.014984 0.0025699 0.0084522
BDKRB1 33.45385 -1.361183 0.4439146 -3.066317 0.0021671 0.0072895
LRATD2 1157.65458 -1.331135 0.3999784 -3.328018 0.0008747 0.0032363
SYNGAP1 3165.00611 -1.329059 0.3624226 -3.667152 0.0002453 0.0011344
BCAN 27602.20501 -1.304338 0.2795404 -4.666010 0.0000031 0.0000246
GRIA3 5108.59991 -1.287321 0.3396874 -3.789724 0.0001508 0.0007440
IGF1 42.02378 1.265174 0.4520960 2.798462 0.0051347 0.0159494
SRC 663.43919 -1.261125 0.3311803 -3.807971 0.0001401 0.0007029
TNF 35.05670 1.260818 0.4768129 2.644261 0.0081869 0.0230794
FERMT2 293.93048 1.227987 0.3669760 3.346233 0.0008192 0.0031087
PAX6 191.49539 -1.210998 0.3792210 -3.193384 0.0014062 0.0048967
HTR3A 25.63823 -1.203554 0.4420268 -2.722808 0.0064730 0.0193535
CAMK2A 1526.72529 1.197719 0.4310558 2.778571 0.0054599 0.0166610
PRKCD 290.39952 -1.188298 0.3471543 -3.422967 0.0006194 0.0025465
ITGA7 702.71945 -1.181834 0.3982090 -2.967873 0.0029987 0.0097540
SHARPIN 411.76969 -1.125597 0.4825242 -2.332726 0.0196625 0.0454465
SORL1 2041.51672 -1.106675 0.2811788 -3.935840 0.0000829 0.0004630
LYNX1 1000.57411 1.081000 0.4446594 2.431073 0.0150542 0.0377630
ERBB2 204.87359 -1.056387 0.4358626 -2.423669 0.0153646 0.0378993
NXPH4 64.48338 1.053289 0.4520549 2.330002 0.0198061 0.0454465
NPAS1 53.43811 -1.020376 0.3930876 -2.595798 0.0094371 0.0257097
CUX2 672.12637 -1.020361 0.3798982 -2.685879 0.0072339 0.0212004
ACE 66.87576 -1.004103 0.4279204 -2.346471 0.0189521 0.0441719

6.12 Pvalb

X baseMean log2FoldChange lfcSE stat pvalue padj
GPHN 340.28709 5.952084 0.5036856 11.817061 0.0000000 0.0000000
GRIA4 1392.34739 5.830218 0.4171307 13.976957 0.0000000 0.0000000
GRM5 408.15278 5.547210 0.5258671 10.548692 0.0000000 0.0000000
CHODL 327.86326 5.157326 1.2315790 4.187572 0.0000282 0.0002318
IFNG 372.50304 4.536237 0.6247318 7.261095 0.0000000 0.0000000
SCTR 83.36617 4.242182 0.7885640 5.379629 0.0000001 0.0000011
DLG4 1070.18286 4.190921 0.3501941 11.967424 0.0000000 0.0000000
SEMA5B 337.08250 3.535134 1.4006621 2.523902 0.0116060 0.0336803
NOS3 116.69930 3.491063 0.6336692 5.509284 0.0000000 0.0000006
RIMS1 327.23853 3.320350 0.4175948 7.951129 0.0000000 0.0000000
CTSS 33.60622 3.272965 0.6324855 5.174767 0.0000002 0.0000029
CXCL10 112.32336 3.207168 0.7341610 4.368481 0.0000125 0.0001089
NR5A1 48.83104 3.150515 0.5549442 5.677174 0.0000000 0.0000003
NDST4 44.09650 3.065051 0.5739225 5.340531 0.0000001 0.0000012
IGF1 164.38701 2.930933 0.5867928 4.994835 0.0000006 0.0000073
GAD2 1489.31169 2.868322 0.4557256 6.293967 0.0000000 0.0000000
SIM1 59.84672 2.824988 0.6911665 4.087275 0.0000436 0.0003313
DRD2 66.07087 -2.748716 0.4481209 -6.133872 0.0000000 0.0000000
AGTR1 18.30880 2.690330 0.7754880 3.469209 0.0005220 0.0029153
MAPK1 489.67133 2.607353 0.3849151 6.773838 0.0000000 0.0000000
CREBBP 1031.84787 -2.578374 0.3508850 -7.348203 0.0000000 0.0000000
TACR2 48.59670 2.551312 0.5969052 4.274234 0.0000192 0.0001622
MEIS2 70.32246 2.470819 0.5354903 4.614124 0.0000039 0.0000377
HTR1A 58.46187 -2.416142 0.4265356 -5.664573 0.0000000 0.0000003
NRG3 294.93222 2.398229 0.4047443 5.925295 0.0000000 0.0000001
OLIG1 106.25306 2.299159 0.4907429 4.685058 0.0000028 0.0000286
MAP4K3 285.04798 2.273376 0.3343909 6.798557 0.0000000 0.0000000
IL1B 25.67686 2.198385 0.6212775 3.538491 0.0004024 0.0024037
CX3CL1 1101.89343 -2.141265 0.3891002 -5.503119 0.0000000 0.0000006
NEGR1 512.15166 2.100561 0.3459740 6.071442 0.0000000 0.0000000
CXCR4 46.49942 -2.056734 0.4617950 -4.453782 0.0000084 0.0000757
SPI1 92.52580 -2.047339 0.5787852 -3.537304 0.0004042 0.0024037
SNCA 197.29272 1.999143 0.4316393 4.631513 0.0000036 0.0000358
TAC1 685.85103 1.977978 0.4871815 4.060042 0.0000491 0.0003631
MTOR 215.77557 1.942150 0.3394867 5.720842 0.0000000 0.0000002
RIMS2 228.24126 1.941239 0.3400633 5.708463 0.0000000 0.0000002
TH 155.42635 -1.908551 0.6885967 -2.771653 0.0055772 0.0193626
PTEN 143.97573 1.904805 0.6670574 2.855535 0.0042964 0.0163045
CRH 262.88631 1.870179 0.3781460 4.945653 0.0000008 0.0000086
EPHA1 32.38911 1.857284 0.5507556 3.372247 0.0007456 0.0037554
KCTD4 21.12645 1.848851 0.7323406 2.524577 0.0115837 0.0336803
GPR15 25.35276 1.841072 0.6475553 2.843112 0.0044675 0.0165299
COCH 54.22919 1.824557 0.4841574 3.768521 0.0001642 0.0011304
CREB1 36.96561 1.784719 0.6353415 2.809070 0.0049685 0.0179350
PILRA 119.04466 1.762130 0.4390910 4.013131 0.0000599 0.0004223
DCN 85.89763 1.732217 0.4147907 4.176122 0.0000297 0.0002372
SLC6A4 24.70304 -1.722382 0.5021651 -3.429912 0.0006038 0.0032494
DBH 74.69448 -1.718401 0.3822887 -4.495035 0.0000070 0.0000643
NMBR 23.09496 1.715958 0.5805034 2.955983 0.0031167 0.0124670
CELSR1 61.84488 1.707006 0.4857077 3.514471 0.0004406 0.0025574
COL11A1 163.42748 1.686403 0.3475749 4.851910 0.0000012 0.0000134
SYT6 40.19859 -1.663037 0.4139876 -4.017119 0.0000589 0.0004223
CD74 346.80846 -1.632049 0.5179169 -3.151180 0.0016261 0.0075208
SNCG 4962.29216 -1.618762 0.2909121 -5.564438 0.0000000 0.0000004
CA12 19.05844 -1.617033 0.5336527 -3.030122 0.0024445 0.0100498
PLAGL1 352.79886 1.604264 0.3240305 4.950967 0.0000007 0.0000086
THEMIS 21.33935 -1.571329 0.5103544 -3.078898 0.0020777 0.0087856
ROS1 62.77118 1.547134 0.4371093 3.539467 0.0004009 0.0024037
NTSR1 17.58394 1.506049 0.5966653 2.524110 0.0115991 0.0336803
PAX6 43.07781 -1.476041 0.6301342 -2.342423 0.0191590 0.0488885
TEK 77.24957 -1.468077 0.4309519 -3.406592 0.0006578 0.0034440
ADGRA1 2507.27239 -1.456749 0.3502849 -4.158754 0.0000320 0.0002493
FEZF2 50.27440 -1.435714 0.4599713 -3.121312 0.0018005 0.0080717
FERMT2 72.12580 1.420855 0.4018111 3.536128 0.0004060 0.0024037
ITGA7 486.23124 -1.414410 0.4195631 -3.371150 0.0007486 0.0037554
PCP4 33.26656 1.407176 0.4877439 2.885071 0.0039133 0.0152411
MRC1 31.66929 1.399190 0.5164531 2.709230 0.0067440 0.0226842
CHRNA5 35.93372 1.388998 0.4993459 2.781634 0.0054086 0.0192413
MMP9 25.74172 -1.386533 0.5079210 -2.729821 0.0063369 0.0215599
FEV 86.88891 1.368685 0.4284468 3.194526 0.0014006 0.0065806
HTR3A 43.09983 -1.342165 0.5009984 -2.678980 0.0073847 0.0240205
GPR55 43.67703 -1.338645 0.5348321 -2.502926 0.0123171 0.0353968
P2RY12 44.82807 1.336356 0.4974422 2.686454 0.0072215 0.0237507
RELN 33.76484 1.336224 0.5127397 2.606047 0.0091594 0.0285357
ACAN 57.13322 1.323579 0.4533445 2.919588 0.0035050 0.0138329
PVALB 970.06691 1.315496 0.4596006 2.862258 0.0042063 0.0161698
NPNT 140.01450 1.314580 0.4218139 3.116491 0.0018302 0.0080717
CAMK2G 3964.22513 -1.312332 0.2754610 -4.764130 0.0000019 0.0000201
CSF1 127.76010 -1.302893 0.4024969 -3.237027 0.0012078 0.0058419
ANPEP 40.82337 1.298939 0.4612517 2.816117 0.0048608 0.0177629
CCK 224.65504 1.280208 0.3431739 3.730494 0.0001911 0.0012570
ID4 28.73801 1.277842 0.5323732 2.400274 0.0163828 0.0436874
SLC29A2 264.40392 1.251082 0.4028021 3.105946 0.0018967 0.0081366
KCNC1 4861.14945 -1.227698 0.3686553 -3.330204 0.0008678 0.0042813
NTNG2 49.73892 -1.222726 0.4091602 -2.988379 0.0028046 0.0113721
BIN1 3135.57396 -1.215988 0.5010166 -2.427042 0.0152225 0.0413381
HS3ST1 293.23717 -1.213702 0.3247905 -3.736876 0.0001863 0.0012534
NPTX1 112.74556 1.208435 0.4238830 2.850868 0.0043600 0.0163362
GPR63 54.30933 1.207502 0.4662365 2.589893 0.0096006 0.0289977
EPHA10 893.24548 -1.200976 0.4526171 -2.653404 0.0079684 0.0256376
SLC32A1 2690.78838 1.174253 0.3735220 3.143733 0.0016681 0.0075962
NOS1 761.81864 -1.169919 0.3348071 -3.494307 0.0004753 0.0027055
UBE3A 341.18459 1.158587 0.3403249 3.404355 0.0006632 0.0034440
ALDH1L1 110.39482 1.132438 0.3685143 3.072982 0.0021193 0.0088355
SYN1 4116.33941 -1.129960 0.3630248 -3.112625 0.0018543 0.0080717
SYNGAP1 2698.27047 -1.114070 0.3445601 -3.233310 0.0012236 0.0058419
LAMP5 136.69001 1.098887 0.4222439 2.602494 0.0092548 0.0285357
LRPPRC 556.08737 1.070031 0.4513367 2.370805 0.0177494 0.0464940
SULF2 473.11428 -1.066464 0.4104676 -2.598169 0.0093722 0.0285998
PDGFRB 53.73567 -1.063282 0.3826762 -2.778541 0.0054604 0.0192413
CALB1 160.45460 1.062729 0.4271686 2.487845 0.0128520 0.0365787
BACE1 1360.10026 -1.059756 0.2991984 -3.541982 0.0003971 0.0024037
GRIN1 8514.36051 -1.039149 0.4182934 -2.484259 0.0129821 0.0365972
CCKBR 279.58801 -1.028149 0.2996567 -3.431090 0.0006012 0.0032494

6.13 Sst

X baseMean log2FoldChange lfcSE stat pvalue padj
IFNG 1488.21771 6.891950 0.4562669 15.105086 0.0000000 0.0000000
CHODL 1183.75152 6.198239 0.8012600 7.735616 0.0000000 0.0000000
SEMA5B 1360.99868 5.538980 0.9565361 5.790665 0.0000000 0.0000001
CXCL10 286.20763 5.430394 0.7713398 7.040210 0.0000000 0.0000000
GRIA4 265.38547 5.414684 0.4763954 11.365945 0.0000000 0.0000000
GRM5 549.40647 5.197752 0.4736929 10.972832 0.0000000 0.0000000
SCTR 112.61571 5.070117 0.9213110 5.503155 0.0000000 0.0000004
GPHN 290.99917 4.744101 0.4533209 10.465216 0.0000000 0.0000000
NOS3 234.66210 4.301517 0.6964796 6.176084 0.0000000 0.0000000
NR5A1 103.55535 4.052104 0.5802559 6.983304 0.0000000 0.0000000
SIM1 251.75073 4.000872 0.7089496 5.643380 0.0000000 0.0000002
DLG4 1035.52067 3.988874 0.3348599 11.912069 0.0000000 0.0000000
MKI67 312.37877 3.846795 0.6876841 5.593841 0.0000000 0.0000003
IGF2 190.63803 3.782507 0.7506568 5.038930 0.0000005 0.0000043
RIMS1 461.75273 3.301260 0.5984212 5.516616 0.0000000 0.0000004
DCN 590.24312 3.294369 0.3714319 8.869374 0.0000000 0.0000000
SNCA 457.81925 2.890106 0.4097364 7.053573 0.0000000 0.0000000
CREBBP 1003.64329 -2.866436 0.3654939 -7.842637 0.0000000 0.0000000
RELN 96.98484 2.834559 0.5803710 4.884047 0.0000010 0.0000093
EPHA1 78.92953 2.827828 0.5426192 5.211441 0.0000002 0.0000020
TACR2 51.47098 2.795365 0.6254281 4.469523 0.0000078 0.0000580
IGF1 151.03075 2.723308 0.4672237 5.828702 0.0000000 0.0000001
FOS 396.80893 2.654723 0.9040249 2.936559 0.0033188 0.0103405
CTSS 28.38568 2.638786 0.5626749 4.689717 0.0000027 0.0000225
MAPK1 548.11273 2.626738 0.3786038 6.937961 0.0000000 0.0000000
GAD2 657.45308 2.619620 0.5035662 5.202135 0.0000002 0.0000020
PTEN 146.98872 2.606390 0.4934755 5.281701 0.0000001 0.0000014
ANPEP 25.78089 2.564605 0.5787487 4.431293 0.0000094 0.0000657
NRG3 258.68395 2.543964 0.4170380 6.100077 0.0000000 0.0000000
CALB1 735.70443 2.450598 0.5670145 4.321931 0.0000155 0.0000995
MAP4K3 406.74255 2.393122 0.3702949 6.462745 0.0000000 0.0000000
IL10 27.56202 2.326722 0.5706171 4.077554 0.0000455 0.0002542
DRD2 84.92723 -2.322850 0.4495377 -5.167197 0.0000002 0.0000023
SPI1 132.40034 -2.318359 0.6956936 -3.332442 0.0008609 0.0033976
AGTR1 20.68230 2.287015 0.6782657 3.371856 0.0007466 0.0030274
RIMS2 531.58611 2.204808 0.3979759 5.540054 0.0000000 0.0000004
TAC1 421.19976 2.141939 0.4837971 4.427350 0.0000095 0.0000657
CX3CL1 839.35945 -2.113065 0.4062508 -5.201380 0.0000002 0.0000020
NEGR1 539.04106 2.078513 0.3594530 5.782434 0.0000000 0.0000001
WNT2 26.44868 2.071733 0.5623815 3.683858 0.0002297 0.0010625
CSF1 155.45333 -2.052071 0.3382692 -6.066385 0.0000000 0.0000000
FEZF2 66.60224 -2.029968 0.4803918 -4.225650 0.0000238 0.0001439
PRKCD 119.66400 -2.017677 0.5783771 -3.488515 0.0004857 0.0020776
SCIMP 57.58269 -1.990989 0.5310755 -3.748975 0.0001776 0.0008342
TEK 172.31329 -1.965196 0.3325531 -5.909422 0.0000000 0.0000001
SNCG 1760.56683 -1.926994 0.3124132 -6.168095 0.0000000 0.0000000
CRH 86.32726 -1.922657 0.6954620 -2.764575 0.0056997 0.0168711
DBH 48.40973 -1.908551 0.4333012 -4.404675 0.0000106 0.0000697
THEMIS 24.30485 -1.879047 0.5117889 -3.671527 0.0002411 0.0010980
MEIS2 83.27739 1.870654 0.4035718 4.635244 0.0000036 0.0000282
ITGA7 581.15182 -1.870236 0.4928175 -3.794986 0.0001477 0.0007165
SOX10 1240.46037 -1.862399 0.4398344 -4.234319 0.0000229 0.0001414
PILRA 118.39565 1.849498 0.4590047 4.029366 0.0000559 0.0002928
HTR1A 197.12364 -1.834969 0.3851400 -4.764419 0.0000019 0.0000165
GRIN3B 56.19990 1.797387 0.4907394 3.662610 0.0002497 0.0011197
SYT6 49.63642 -1.779623 0.4012921 -4.434732 0.0000092 0.0000657
ADRB1 46.38222 1.774972 0.4556572 3.895411 0.0000980 0.0004836
MRC1 54.35473 1.767587 0.4387836 4.028379 0.0000562 0.0002928
OXGR1 12.19869 -1.756837 0.5920972 -2.967142 0.0030058 0.0094651
IL1B 43.77332 1.753588 0.6140714 2.855674 0.0042946 0.0129713
LAMP5 140.51257 1.750126 0.4618641 3.789266 0.0001511 0.0007213
NRG1 84.37268 -1.747660 0.3678818 -4.750602 0.0000020 0.0000172
TH 220.26829 -1.735815 0.4418850 -3.928206 0.0000856 0.0004294
OPRM1 60.12939 1.733261 0.6680805 2.594390 0.0094759 0.0262137
MTOR 192.66764 1.700157 0.3859489 4.405134 0.0000106 0.0000697
HTR3A 23.13835 -1.676839 0.6375722 -2.630038 0.0085375 0.0240677
NPAS1 722.19967 -1.631281 0.3521826 -4.631918 0.0000036 0.0000282
ACE 84.08343 -1.626697 0.3832427 -4.244560 0.0000219 0.0001379
NDST4 59.16470 1.622935 0.5137955 3.158717 0.0015847 0.0055183
PCP4 35.99630 1.619927 0.4869851 3.326441 0.0008796 0.0034259
COCH 81.05979 1.604176 0.4869942 3.294036 0.0009876 0.0037478
CA12 28.91592 -1.591396 0.4590994 -3.466343 0.0005276 0.0021995
HS3ST1 358.37963 -1.587702 0.4809597 -3.301112 0.0009630 0.0037020
KCND2 1330.48970 -1.549750 0.4299317 -3.604643 0.0003126 0.0013607
COL11A1 101.67327 1.518902 0.3732152 4.069776 0.0000471 0.0002579
NOSTRIN 75.00587 -1.487123 0.3752062 -3.963482 0.0000739 0.0003770
KCTD4 50.16988 1.479254 0.6261568 2.362434 0.0181554 0.0451596
TNF 38.04683 1.477726 0.4899301 3.016198 0.0025597 0.0082354
ID4 39.51288 1.467647 0.4827199 3.040370 0.0023629 0.0078585
NTNG2 72.38506 -1.451411 0.3971488 -3.654578 0.0002576 0.0011381
ADGRA1 1192.13488 -1.444576 0.3488873 -4.140525 0.0000347 0.0002011
TSHZ1 176.38960 -1.442498 0.4230256 -3.409955 0.0006497 0.0026711
OLIG1 237.69347 1.441762 0.4136528 3.485439 0.0004913 0.0020776
CD74 540.75094 -1.425958 0.4706999 -3.029442 0.0024501 0.0080580
BIN1 3730.20975 -1.424764 0.5249719 -2.713981 0.0066480 0.0194832
P2RY12 63.23210 1.413512 0.5302641 2.665675 0.0076834 0.0222969
PLAGL1 535.22978 1.400413 0.3377098 4.146793 0.0000337 0.0001996
NPTX1 114.32356 1.393764 0.4431272 3.145291 0.0016592 0.0056452
NMBR 85.68942 1.387848 0.5438667 2.551817 0.0107163 0.0288365
BACE1 1498.90433 -1.383759 0.3080311 -4.492269 0.0000070 0.0000535
CST7 13.36558 -1.379371 0.5443120 -2.534156 0.0112719 0.0300583
ROS1 64.87207 1.337721 0.4247436 3.149479 0.0016356 0.0056296
SLC6A4 31.77926 -1.336969 0.4418404 -3.025908 0.0024789 0.0080632
CCK 144.13237 1.318131 0.4161859 3.167168 0.0015393 0.0054243
FEV 112.45310 1.309770 0.4993021 2.623201 0.0087108 0.0243245
MRC2 50.45395 -1.302308 0.5290489 -2.461602 0.0138318 0.0352949
SYN1 4760.08105 -1.289367 0.4066811 -3.170463 0.0015220 0.0054243
KCNC1 2387.05643 -1.282819 0.4286001 -2.993044 0.0027621 0.0087912
NOS1 1893.97847 -1.279388 0.3996970 -3.200895 0.0013700 0.0050065
CASS4 36.46523 1.264154 0.4749907 2.661429 0.0077810 0.0223609
NDNF 19.09902 -1.258566 0.5375134 -2.341460 0.0192085 0.0469893
KCNQ1 28.50683 -1.258566 0.4403539 -2.858078 0.0042622 0.0129713
SORL1 706.32689 -1.250493 0.3050474 -4.099339 0.0000414 0.0002359
CAMK2G 3371.48995 -1.245436 0.3092387 -4.027427 0.0000564 0.0002928
SYNGAP1 2807.75275 -1.241818 0.3811622 -3.257977 0.0011221 0.0042043
IYD 158.90661 -1.222686 0.3651934 -3.348052 0.0008138 0.0032553
SLC32A1 2403.53256 1.200335 0.3830386 3.133719 0.0017261 0.0058058
SYP 7318.39438 -1.195886 0.3728395 -3.207508 0.0013389 0.0049539
CHRM4 130.34502 -1.177297 0.3708893 -3.174255 0.0015022 0.0054226
SERPINF1 54.12857 -1.169652 0.4933908 -2.370639 0.0177574 0.0445439
FIBCD1 41.32796 1.159827 0.4659374 2.489234 0.0128019 0.0332399
SLC29A2 193.70536 1.067836 0.4029447 2.650080 0.0080473 0.0229037
PDGFRB 128.18041 -1.030980 0.4007583 -2.572572 0.0100946 0.0274128
CD33 66.51333 -1.012736 0.4313185 -2.348000 0.0188745 0.0465571

6.14 Vip

X baseMean log2FoldChange lfcSE stat pvalue padj
GPHN 410.56533 5.784081 0.4933403 11.724322 0.0000000 0.0000000
GRIA4 596.58599 5.559792 0.4210974 13.203101 0.0000000 0.0000000
IFNG 417.10767 5.455981 0.5754961 9.480482 0.0000000 0.0000000
GRM5 218.31364 4.823765 0.4987705 9.671311 0.0000000 0.0000000
DLG4 1099.33797 3.883077 0.3621651 10.721839 0.0000000 0.0000000
CHODL 210.57534 3.829398 1.3346625 2.869188 0.0041153 0.0145014
RIMS1 442.51716 3.618316 0.4741628 7.630957 0.0000000 0.0000000
RELN 171.15182 3.243455 0.4223318 7.679875 0.0000000 0.0000000
NR5A1 59.66987 3.048414 0.5803883 5.252369 0.0000002 0.0000018
CREBBP 1178.59633 -3.020566 0.2989304 -10.104581 0.0000000 0.0000000
CXCL10 74.48545 2.929150 0.7275697 4.025938 0.0000567 0.0003652
NOS3 96.60562 2.878440 0.6081365 4.733214 0.0000022 0.0000204
SIM1 56.73271 2.835945 0.8306192 3.414254 0.0006396 0.0030534
IGF1 188.29693 2.759414 0.4785596 5.766083 0.0000000 0.0000001
DCN 254.02366 2.660865 0.3587858 7.416305 0.0000000 0.0000000
SNCA 321.42541 2.567000 0.3533476 7.264799 0.0000000 0.0000000
GAD2 544.82124 2.475666 0.3439656 7.197423 0.0000000 0.0000000
THEMIS 34.97609 -2.453336 0.5371528 -4.567296 0.0000049 0.0000442
PTEN 108.80777 2.427521 0.5844462 4.153540 0.0000327 0.0002254
TACR2 58.04650 2.398233 0.6295667 3.809339 0.0001393 0.0008593
MAPK1 485.34604 2.393031 0.3423434 6.990149 0.0000000 0.0000000
DBH 57.70269 -2.247564 0.4371185 -5.141773 0.0000003 0.0000030
GRIN3B 44.31360 2.210092 0.5894771 3.749242 0.0001774 0.0010715
NDST4 51.80722 2.205069 0.5151306 4.280602 0.0000186 0.0001346
CX3CL1 828.30539 -2.185628 0.3427474 -6.376789 0.0000000 0.0000000
NDNF 191.56993 2.151440 0.3742601 5.748514 0.0000000 0.0000001
MEIS2 73.70649 2.143592 0.4911649 4.364303 0.0000128 0.0000993
NRG3 337.08149 2.094395 0.3978113 5.264795 0.0000001 0.0000017
MTOR 205.80689 2.070560 0.4254242 4.867048 0.0000011 0.0000116
OLIG1 217.69294 2.060843 0.3597598 5.728386 0.0000000 0.0000002
SYT6 497.41071 -2.048236 0.3152753 -6.496660 0.0000000 0.0000000
CHRNA5 20.63370 2.040136 0.7327673 2.784153 0.0053668 0.0178490
NEGR1 267.25477 2.038705 0.3761580 5.419811 0.0000001 0.0000008
FEZF2 53.93860 -2.034863 0.4576196 -4.446625 0.0000087 0.0000717
CXCR4 68.49739 -2.010964 0.5485715 -3.665819 0.0002465 0.0014034
ROS1 59.47161 1.951321 0.5701792 3.422293 0.0006210 0.0030131
P2RY12 55.99871 1.935939 0.5732902 3.376892 0.0007331 0.0033906
GPR15 26.48090 1.926637 0.6127610 3.144190 0.0016655 0.0068469
HTR1A 79.41860 -1.923060 0.4057046 -4.740049 0.0000021 0.0000204
CTSS 31.41209 1.919542 0.5736701 3.346073 0.0008196 0.0036760
MAP4K3 262.22598 1.905688 0.3559638 5.353601 0.0000001 0.0000011
ACE 178.93605 -1.889597 0.3955889 -4.776668 0.0000018 0.0000176
FLT1 94.99237 1.886323 0.4135215 4.561607 0.0000051 0.0000442
VIPR2 305.11989 -1.860169 0.3254128 -5.716337 0.0000000 0.0000002
IL10 21.82412 1.853715 0.7052127 2.628590 0.0085740 0.0261969
MKI67 115.99376 1.841067 0.7489149 2.458312 0.0139592 0.0386161
ADGRA1 2527.10088 -1.793111 0.3448929 -5.199037 0.0000002 0.0000023
SNCG 554.07333 -1.749969 0.2872449 -6.092255 0.0000000 0.0000000
HS3ST1 169.83489 -1.736920 0.3968778 -4.376460 0.0000121 0.0000965
RIMS2 352.39063 1.718003 0.3378713 5.084787 0.0000004 0.0000039
NPY1R 220.36279 1.715825 0.4858782 3.531390 0.0004134 0.0021850
PTK2B 1047.16268 -1.685090 0.2817674 -5.980430 0.0000000 0.0000000
PDGFRB 200.75573 -1.684682 0.5025966 -3.351957 0.0008024 0.0036541
KCNC1 2074.02962 -1.632832 0.3621753 -4.508404 0.0000065 0.0000552
CAMK2G 2635.01653 -1.631952 0.3048421 -5.353435 0.0000001 0.0000011
SLC6A4 26.79980 -1.600496 0.5129863 -3.119959 0.0018088 0.0073342
PRKCD 757.29166 -1.582603 0.4490322 -3.524476 0.0004243 0.0022035
NPNT 54.10145 1.569306 0.4641388 3.381114 0.0007219 0.0033906
KCTD4 39.04981 1.565725 0.6163843 2.540177 0.0110797 0.0315344
KCNQ1 34.53296 -1.551109 0.6328008 -2.451181 0.0142388 0.0390249
LGALS3 83.67334 -1.536642 0.4217223 -3.643730 0.0002687 0.0015008
TYROBP 69.91197 -1.522857 0.3884111 -3.920735 0.0000883 0.0005560
ANPEP 24.84326 1.519000 0.6005466 2.529363 0.0114270 0.0322132
NOS1 215.06094 -1.503372 0.3569481 -4.211739 0.0000253 0.0001786
NMBR 34.41919 1.494858 0.5857573 2.552009 0.0107104 0.0307793
BDKRB1 16.89017 -1.487124 0.6297600 -2.361413 0.0182054 0.0489891
NPAS1 702.66290 -1.452998 0.4140002 -3.509655 0.0004487 0.0022510
TSHZ1 649.22672 -1.432170 0.3319683 -4.314177 0.0000160 0.0001216
EPHA1 36.86953 1.428743 0.5457957 2.617725 0.0088518 0.0267361
SYN1 4216.83974 -1.389605 0.3860563 -3.599488 0.0003188 0.0017477
BIN1 3805.62249 -1.385085 0.4783609 -2.895481 0.0037858 0.0138345
CELSR1 85.64870 1.364709 0.4138864 3.297303 0.0009762 0.0041877
NR2F2 1234.40051 1.343168 0.3607243 3.723531 0.0001965 0.0011630
CSF1 172.09303 -1.337484 0.3804395 -3.515630 0.0004387 0.0022389
ID4 41.34369 1.336587 0.5315621 2.514452 0.0119218 0.0332910
SYNGAP1 3081.26332 -1.335130 0.3292438 -4.055140 0.0000501 0.0003296
BACE1 1402.39577 -1.321662 0.3073258 -4.300522 0.0000170 0.0001261
EPHA10 1093.95262 -1.310048 0.4142659 -3.162337 0.0015651 0.0065249
TRPM4 150.12573 -1.298979 0.4787880 -2.713056 0.0066666 0.0212184
PENK 568.93710 -1.294883 0.5497526 -2.355392 0.0185032 0.0493418
PILRA 150.81315 1.292487 0.4352260 2.969693 0.0029810 0.0114593
MRC1 55.99508 1.268354 0.4568041 2.776582 0.0054934 0.0180671
MRC2 53.83025 -1.254733 0.4343296 -2.888895 0.0038660 0.0139207
LAMP5 350.16481 1.254369 0.3825197 3.279227 0.0010409 0.0044016
SCTR 102.56488 1.227219 0.4715639 2.602445 0.0092562 0.0276750
SULF2 670.58308 -1.226557 0.3019359 -4.062309 0.0000486 0.0003269
SYP 7776.09391 -1.201513 0.3642757 -3.298362 0.0009725 0.0041877
NTNG2 182.93226 -1.200301 0.5028278 -2.387100 0.0169818 0.0461158
PAX6 258.85375 -1.195971 0.3346052 -3.574275 0.0003512 0.0018901
NGF 146.49226 -1.192212 0.4184633 -2.849026 0.0043853 0.0150937
NPTX2 435.47447 -1.190717 0.3242959 -3.671700 0.0002409 0.0013984
FERMT2 100.58039 1.179852 0.4019495 2.935323 0.0033320 0.0126445
CD33 53.19536 -1.161391 0.4541510 -2.557280 0.0105494 0.0306140
GRIN1 11285.15367 -1.142415 0.4262134 -2.680383 0.0073538 0.0231567
PSEN2 848.19870 -1.129026 0.3260203 -3.463054 0.0005341 0.0026348
KCND2 1059.58989 -1.127086 0.3407888 -3.307287 0.0009420 0.0041619
SLC29A2 294.78101 1.125577 0.4115641 2.734876 0.0062404 0.0202984
FEV 76.17482 1.113483 0.4312950 2.581721 0.0098309 0.0288114
CCKBR 92.06916 -1.111433 0.3710937 -2.995021 0.0027443 0.0106882
SOX10 662.15797 -1.072294 0.3715679 -2.885862 0.0039034 0.0139207
COCH 119.40811 1.032764 0.3797325 2.719715 0.0065338 0.0210218
SLC17A7 367.19790 -1.027394 0.3418851 -3.005085 0.0026551 0.0104787
CHRM4 132.24569 -1.011812 0.3609908 -2.802873 0.0050650 0.0172325

6.15 VLMC

X baseMean log2FoldChange lfcSE stat pvalue padj
SIM1 117.600877 8.254573 1.4537765 5.678021 0.0000000 0.0000003
IFNG 970.673333 8.230679 0.7382515 11.148883 0.0000000 0.0000000
GRIA4 46.016099 7.867570 1.2874097 6.111163 0.0000000 0.0000000
CHODL 525.928133 7.461283 0.8964992 8.322687 0.0000000 0.0000000
CXCL10 158.650491 7.209771 1.1530066 6.253018 0.0000000 0.0000000
SCTR 87.964908 6.975233 1.2288454 5.676250 0.0000000 0.0000003
GRM5 204.470931 6.896581 0.8684446 7.941302 0.0000000 0.0000000
MKI67 174.112149 5.439940 0.8314156 6.542986 0.0000000 0.0000000
NR5A1 44.682307 4.897483 0.9396430 5.212068 0.0000002 0.0000027
SEMA5B 729.513710 4.659609 0.8957639 5.201828 0.0000002 0.0000027
GPHN 60.332773 4.159299 0.6752165 6.159949 0.0000000 0.0000000
FLT1 472.072216 4.107574 0.5908651 6.951797 0.0000000 0.0000000
OXGR1 6.489657 3.968238 1.3076059 3.034735 0.0024075 0.0105188
DLG4 180.439697 3.943432 0.4725733 8.344593 0.0000000 0.0000000
P2RY12 41.062379 3.869982 0.8705614 4.445386 0.0000088 0.0000958
CACNG5 38.723305 3.791910 0.7144684 5.307317 0.0000001 0.0000017
ROS1 15.028704 3.715452 0.9766359 3.804337 0.0001422 0.0009614
CREBBP 823.175188 -3.595769 0.3766104 -9.547716 0.0000000 0.0000000
PTEN 250.783871 3.517124 0.5859476 6.002456 0.0000000 0.0000000
TNF 17.788558 3.443856 0.9108448 3.780947 0.0001562 0.0009860
CHRNA5 20.659327 3.427133 0.8208359 4.175175 0.0000298 0.0002819
LAMP5 75.903513 3.227441 0.5513949 5.853230 0.0000000 0.0000001
NOS3 199.471843 3.058614 0.4208324 7.268009 0.0000000 0.0000000
EPHA7 53.332988 3.037418 0.6225200 4.879230 0.0000011 0.0000132
IL10 8.356251 2.748831 0.9971266 2.756752 0.0058379 0.0215318
NRG3 13.071074 2.669857 0.8403717 3.176995 0.0014881 0.0067082
ADAM10 21.089574 2.608650 0.9386697 2.779093 0.0054511 0.0206415
MS4A7 19.465893 2.530736 0.8233609 3.073666 0.0021145 0.0093829
SERPINF1 25.490283 2.508265 0.7679458 3.266200 0.0010900 0.0049930
CELSR1 33.925608 2.492888 0.6382772 3.905651 0.0000940 0.0007793
RIMS1 23.698095 2.490205 0.7482116 3.328209 0.0008741 0.0041372
COL11A1 64.641796 2.393600 0.6341653 3.774410 0.0001604 0.0009902
CDH12 18.474119 2.365544 0.7121052 3.321902 0.0008941 0.0041625
CCR6 12.242042 -2.344536 0.6416773 -3.653762 0.0002584 0.0014679
MAPK1 211.153191 2.318880 0.4276082 5.422908 0.0000001 0.0000009
CD74 2120.943896 -2.236527 0.3950356 -5.661583 0.0000000 0.0000003
RBP4 189.337216 2.236147 0.5764517 3.879157 0.0001048 0.0008269
FEZF2 26.295487 -2.191028 0.4972761 -4.406059 0.0000105 0.0001107
TLX3 10.347715 -2.164857 0.7161511 -3.022906 0.0025036 0.0107731
NEGR1 25.927707 2.117191 0.5861473 3.612045 0.0003038 0.0016592
NTF3 10.299559 2.057702 0.8502232 2.420190 0.0155124 0.0495002
FOXP2 20.241435 2.052555 0.7106070 2.888454 0.0038714 0.0157069
CTSS 14.733468 1.985380 0.7161979 2.772111 0.0055694 0.0208120
PENK 14.888561 1.978433 0.7592220 2.605870 0.0091641 0.0321310
SNCA 46.746834 1.964168 0.5158523 3.807617 0.0001403 0.0009614
PILRA 27.920698 1.924266 0.7051481 2.728882 0.0063549 0.0231385
CX3CL1 234.139102 -1.915500 0.4144453 -4.621840 0.0000038 0.0000450
MTOR 70.864453 1.852396 0.5392507 3.435130 0.0005923 0.0029001
DCN 2405.289261 1.837641 0.4711448 3.900374 0.0000960 0.0007793
LMNA 977.724023 1.776071 0.4675895 3.798355 0.0001457 0.0009620
TLR4 37.745762 1.761293 0.5055683 3.483789 0.0004944 0.0026000
SNCG 700.992349 -1.742150 0.3191162 -5.459297 0.0000000 0.0000008
PRKCD 169.050497 -1.736112 0.4137967 -4.195566 0.0000272 0.0002666
SPI1 79.228834 -1.710767 0.3831755 -4.464707 0.0000080 0.0000911
NPY1R 53.334531 1.708423 0.4484314 3.809776 0.0001391 0.0009614
MEIS2 20.262502 1.653820 0.6514212 2.538788 0.0111237 0.0380619
NPTX1 20.355523 1.621726 0.6329914 2.562003 0.0104070 0.0360439
CAMK2G 904.936161 -1.604090 0.3998304 -4.011926 0.0000602 0.0005517
KCNQ1 50.769743 -1.575926 0.4229383 -3.726136 0.0001944 0.0011504
INPP5D 469.239046 -1.567305 0.3089147 -5.073586 0.0000004 0.0000050
BACE1 259.903692 -1.549779 0.3636679 -4.261524 0.0000203 0.0002059
NOS1 67.878370 -1.540205 0.4462020 -3.451811 0.0005568 0.0028240
IGF2 3979.441687 -1.513813 0.4329813 -3.496256 0.0004718 0.0025283
NPNT 26.385997 1.513502 0.5727782 2.642388 0.0082324 0.0292249
MAP4K3 145.229248 1.505041 0.3899473 3.859600 0.0001136 0.0008488
TRPM4 438.253147 -1.492562 0.4309379 -3.463521 0.0005332 0.0027530
MRC2 1900.295394 -1.477577 0.3903540 -3.785223 0.0001536 0.0009860
OLIG1 62.413941 1.448667 0.4295839 3.372257 0.0007455 0.0035887
SHARPIN 190.673068 -1.423941 0.4848040 -2.937147 0.0033125 0.0140409
NXPH4 38.437516 1.395830 0.4768926 2.926926 0.0034233 0.0142973
COCH 32.286080 1.348479 0.5449378 2.474556 0.0133402 0.0435472
NR2F2 1343.361336 1.238698 0.3206514 3.863068 0.0001120 0.0008488
CD4 372.008585 -1.235344 0.3097733 -3.987896 0.0000667 0.0005916
FGFR3 201.988963 -1.224971 0.3564874 -3.436225 0.0005899 0.0029001
CSF1 527.326016 -1.218185 0.3314507 -3.675312 0.0002376 0.0013769
GRIA2 71.398346 1.213539 0.4292041 2.827416 0.0046925 0.0182559
ITGA7 3424.763375 -1.194525 0.4519630 -2.642971 0.0082182 0.0292249
ADAM17 313.810578 -1.174121 0.3115456 -3.768697 0.0001641 0.0009916
COL5A2 338.439319 -1.163423 0.4025094 -2.890424 0.0038472 0.0157069
CLDN5 3366.317797 -1.143951 0.2969905 -3.851810 0.0001172 0.0008538
PDGFRB 7434.439408 -1.119163 0.3078334 -3.635612 0.0002773 0.0015443
SYNGAP1 688.665014 -1.117878 0.4492567 -2.488283 0.0128362 0.0423892
APP 4577.493000 -1.112005 0.2799745 -3.971809 0.0000713 0.0006139
SLC17A7 182.539276 -1.087110 0.4449370 -2.443290 0.0145541 0.0469699
ABI3 70.186679 -1.081501 0.4327635 -2.499058 0.0124524 0.0416056
TSHZ1 281.320573 -1.015049 0.3523980 -2.880406 0.0039716 0.0158865

7. Gene differentiation expresssion (B11 v.s. Temporal Lobe)

Here, we use Wilcoxon rank-sum test to compute gene differential expression (DE). P value are adjusted using Benjamini–Hochberg procedure. The statistical significance was cut-off by log2(Fold Change) > 1 or log2(Fold Change) < -1 and p_value < 0.05.

The result are visualized via Volcano plot: a type of scatterplot that shows statistical significance (P value) versus magnitude of change (fold change).

The comparison is between B11 and Temporal Lobe Epilepsy samples. A positive fold change means higher expression in the Temporal Lobe Epilepsy group.

5.1 All

names scores logfoldchanges pvals pvals_adj
EPHA1 3.500605 2.353679 0.0004642 0.0009804
CA12 5.946485 2.026320 0.0000000 0.0000000
BDKRB1 2.703060 1.962244 0.0068704 0.0124686
SLC6A4 3.842847 1.883271 0.0001216 0.0002746
HCAR1 12.161648 1.850296 0.0000000 0.0000000
ADAM10 5.659477 1.841886 0.0000000 0.0000000
TLX3 9.016754 1.827301 0.0000000 0.0000000
SLCO2A1 4.632980 1.815597 0.0000036 0.0000089
IL23R 3.759074 1.808289 0.0001705 0.0003781
FOS -25.408777 -1.801347 0.0000000 0.0000000
ASPA 21.811375 1.769311 0.0000000 0.0000000
NKX6-2 44.757523 1.718044 0.0000000 0.0000000
SH3TC2 30.211113 1.702101 0.0000000 0.0000000
ABCC9 2.237317 1.664891 0.0252657 0.0425436
GLP2R 8.379714 1.664579 0.0000000 0.0000000
NPTX2 30.257084 1.659736 0.0000000 0.0000000
CTNNA3 5.694786 1.624130 0.0000000 0.0000000
PKP2 3.355081 1.575230 0.0007934 0.0016267
VIPR2 5.122368 1.556263 0.0000003 0.0000008
GLDN 49.381720 1.556250 0.0000000 0.0000000
SOX8 33.425533 1.543607 0.0000000 0.0000000
UGT8 19.222967 1.538733 0.0000000 0.0000000
TMEM106B 2.494486 1.536464 0.0126140 0.0222333
TPBG 5.530914 1.535824 0.0000000 0.0000001
MTOR 10.018521 1.525078 0.0000000 0.0000000
HEATR3 5.753680 1.506735 0.0000000 0.0000000
BIN1 98.749220 1.485429 0.0000000 0.0000000
GPR37 47.131435 1.472537 0.0000000 0.0000000
GABRA2 4.130517 1.462841 0.0000362 0.0000849
HNRNPU 78.337105 1.460166 0.0000000 0.0000000
CNTNAP2 18.557348 1.455391 0.0000000 0.0000000
CDKN1C 17.139105 1.451142 0.0000000 0.0000000
FEV 4.125896 1.418070 0.0000369 0.0000862
TNC -5.723496 -1.403268 0.0000000 0.0000000
ABCA8 7.928769 1.384042 0.0000000 0.0000000
AUTS2 14.601291 1.344267 0.0000000 0.0000000
NR2F2 6.301855 1.330224 0.0000000 0.0000000
CAMK2A 23.141506 1.321158 0.0000000 0.0000000
CCDC88A 35.193707 1.315991 0.0000000 0.0000000
PROX1 31.075785 1.314245 0.0000000 0.0000000
SGK2 28.550497 1.293376 0.0000000 0.0000000
CDH7 9.604843 1.288452 0.0000000 0.0000000
CNTN2 51.071133 1.259440 0.0000000 0.0000000
GPR63 5.121681 1.232040 0.0000003 0.0000008
ABCA2 65.600380 1.223129 0.0000000 0.0000000
EPHA10 12.879268 1.218032 0.0000000 0.0000000
SEPTIN4 59.365578 1.216865 0.0000000 0.0000000
GAL3ST1 24.364605 1.190907 0.0000000 0.0000000
SHARPIN 17.861265 1.183155 0.0000000 0.0000000
SNX14 2.411579 1.179124 0.0158836 0.0275016
LYNX1 28.419455 1.169345 0.0000000 0.0000000
ITGAL 6.957797 1.165525 0.0000000 0.0000000
ANLN 7.710851 1.163642 0.0000000 0.0000000
LAMP5 6.615628 1.162166 0.0000000 0.0000000
PCDH7 2.605250 1.147676 0.0091807 0.0164181
MOBP 36.955746 1.138206 0.0000000 0.0000000
CAMTA1 3.676984 1.134351 0.0002360 0.0005072
TTC21B 7.227595 1.125767 0.0000000 0.0000000
MEIS2 4.292684 1.119784 0.0000177 0.0000426
CUX2 11.356997 1.108759 0.0000000 0.0000000
OPN3 3.689623 1.107512 0.0002246 0.0004848
FGFR2 18.033133 1.106155 0.0000000 0.0000000
CLDN11 6.817818 1.100985 0.0000000 0.0000000
AQP1 -19.140047 -1.097956 0.0000000 0.0000000
NTNG2 16.300919 1.094115 0.0000000 0.0000000
SLC32A1 4.490956 1.093683 0.0000071 0.0000174
ADARB2 7.133257 1.083592 0.0000000 0.0000000
ELOVL1 35.550730 1.081073 0.0000000 0.0000000
ANXA1 -4.184539 -1.061050 0.0000286 0.0000680
TMEM98 10.317035 1.054849 0.0000000 0.0000000
SV2C 3.405163 1.045510 0.0006612 0.0013671
CHRM4 5.089490 1.042697 0.0000004 0.0000009
KCNH8 10.187960 1.038429 0.0000000 0.0000000
TSC1 31.011574 1.037154 0.0000000 0.0000000
SGK1 15.756825 1.020537 0.0000000 0.0000000
SCN4B 7.304902 1.020530 0.0000000 0.0000000
SLC44A1 6.692385 1.018859 0.0000000 0.0000000
ATXN1 32.499740 1.017804 0.0000000 0.0000000
NLK 3.819023 1.016906 0.0001340 0.0003012
MCAM 32.593235 1.002228 0.0000000 0.0000000
MOG 39.927475 1.002000 0.0000000 0.0000000
LRATD2 13.896486 1.000932 0.0000000 0.0000000

5.2 Astrocytes

names scores logfoldchanges pvals pvals_adj
NR2F2 4.106362 4.425458 0.0000402 0.0001790
FOS -38.190550 -4.254431 0.0000000 0.0000000
CA12 9.353842 3.315175 0.0000000 0.0000000
TGFBR2 -5.780868 -2.572330 0.0000000 0.0000000
C3 -18.692926 -2.324472 0.0000000 0.0000000
SEMA5B 3.226662 2.202422 0.0012524 0.0049491
P2RY6 -6.182395 -2.104639 0.0000000 0.0000000
MRC2 6.005584 2.077148 0.0000000 0.0000000
GPNMB -5.330295 -2.044865 0.0000001 0.0000005
SLC2A4 7.572840 2.014563 0.0000000 0.0000000
HLA-DRA -5.539760 -1.807433 0.0000000 0.0000002
ICAM1 -7.244293 -1.753840 0.0000000 0.0000000
KCND2 7.385154 1.736501 0.0000000 0.0000000
SNCG 16.356686 1.674984 0.0000000 0.0000000
FGFR3 61.318604 1.622886 0.0000000 0.0000000
VCAM1 -4.682678 -1.603779 0.0000028 0.0000137
ANXA1 -4.621762 -1.563560 0.0000038 0.0000178
COL11A1 8.673438 1.546124 0.0000000 0.0000000
NTNG2 22.641668 1.544701 0.0000000 0.0000000
CAMTA1 2.879122 1.541877 0.0039878 0.0143680
GRM1 2.956433 1.526282 0.0031122 0.0113804
AUTS2 5.055980 1.517197 0.0000004 0.0000022
NKD1 2.763991 1.508740 0.0057099 0.0202743
FZD9 2.910216 1.404740 0.0036118 0.0131094
SOX8 3.861046 1.395236 0.0001129 0.0004811
HMGCS1 -3.379700 -1.373150 0.0007256 0.0029631
TNC -12.658270 -1.365911 0.0000000 0.0000000
CD74 -15.960001 -1.357972 0.0000000 0.0000000
SEPTIN4 19.025312 1.339954 0.0000000 0.0000000
SOX1 3.107804 1.307594 0.0018848 0.0072154
FZD8 10.487715 1.291580 0.0000000 0.0000000
SLC7A5 6.440521 1.269426 0.0000000 0.0000000
TLR4 7.979957 1.268552 0.0000000 0.0000000
FEZF2 12.049705 1.266888 0.0000000 0.0000000
PDGFRB 32.339810 1.265595 0.0000000 0.0000000
GRIK2 4.306394 1.255528 0.0000166 0.0000753
ECHDC3 -2.693519 -1.196558 0.0070702 0.0249238
TRIB2 15.878796 1.173026 0.0000000 0.0000000
HNRNPU 24.139620 1.172100 0.0000000 0.0000000
GRIA2 18.394220 1.151093 0.0000000 0.0000000
MEIS2 3.418098 1.143772 0.0006306 0.0025966
WFS1 29.250930 1.132877 0.0000000 0.0000000
MAPK1 4.167468 1.119873 0.0000308 0.0001385
LRATD2 2.554300 1.109246 0.0106402 0.0364593
CERS2 7.061147 1.094163 0.0000000 0.0000000
KREMEN1 7.147086 1.081092 0.0000000 0.0000000
SLC1A2 28.512697 1.074462 0.0000000 0.0000000
ADGRA1 3.254810 1.056068 0.0011347 0.0045573
SHARPIN 6.276836 1.042543 0.0000000 0.0000000
ALDH1L1 35.612190 1.030445 0.0000000 0.0000000
SGK2 5.102135 1.030131 0.0000003 0.0000018
STRADA 14.191921 1.023474 0.0000000 0.0000000
CAMK2A 4.715082 1.002543 0.0000024 0.0000118
BCAN 35.771732 1.002022 0.0000000 0.0000000

5.3 Endothelial

names scores logfoldchanges pvals pvals_adj
AQP1 -4.069438 -3.363505 0.0000471 0.0006998
FOS -21.945929 -2.141309 0.0000000 0.0000000
SLCO2A1 4.846393 1.755480 0.0000013 0.0000228
SLC7A5 34.342920 1.745912 0.0000000 0.0000000
DEPTOR 10.783356 1.509623 0.0000000 0.0000000
FZD8 3.130658 1.487521 0.0017442 0.0194235
CD2AP 5.567244 1.417248 0.0000000 0.0000006
BGN 6.409152 1.312592 0.0000000 0.0000000
LYNX1 3.048123 1.311240 0.0023028 0.0245293
HNRNPU 12.774236 1.265624 0.0000000 0.0000000
LMNA -5.225600 -1.199290 0.0000002 0.0000035
DVL1 3.243697 1.154089 0.0011799 0.0144537
CREBBP 14.502749 1.153995 0.0000000 0.0000000
NKD1 8.964833 1.138319 0.0000000 0.0000000
SHARPIN 3.211210 1.131684 0.0013218 0.0154207
FGF1 -5.191480 -1.122243 0.0000002 0.0000041
TSC1 3.670490 1.116184 0.0002421 0.0032060
FLNA -9.045603 -1.054510 0.0000000 0.0000000

5.4 L2_3_4 IT

names scores logfoldchanges pvals pvals_adj
NR2F2 3.807780 4.289285 0.0001402 0.0006190
CSPG4 2.579513 3.813786 0.0098940 0.0343833
GRIN3A -12.407755 -2.965390 0.0000000 0.0000000
NPTX2 20.950878 2.704012 0.0000000 0.0000000
PROX1 2.589323 2.506813 0.0096165 0.0336576
SOX1 4.881565 2.349728 0.0000011 0.0000058
DRD2 2.809394 2.189848 0.0049635 0.0183704
CALB1 -8.827926 -2.159043 0.0000000 0.0000000
LAMP5 21.225294 2.154468 0.0000000 0.0000000
SV2C 4.723542 2.145492 0.0000023 0.0000118
WFS1 13.303240 1.969712 0.0000000 0.0000000
ITGA7 9.252903 1.926115 0.0000000 0.0000000
TTC21B 4.759640 1.664891 0.0000019 0.0000101
HNRNPU 22.055468 1.627736 0.0000000 0.0000000
CAMK2A 27.117563 1.620410 0.0000000 0.0000000
HTR1A 8.802076 1.612974 0.0000000 0.0000000
PAX6 -3.409070 -1.598302 0.0006518 0.0027068
EPHA7 5.912348 1.591129 0.0000000 0.0000000
GLP2R 6.623502 1.456831 0.0000000 0.0000000
ADRB1 9.906328 1.438273 0.0000000 0.0000000
VRK2 -3.402483 -1.415909 0.0006678 0.0027496
GRIK2 19.709358 1.377377 0.0000000 0.0000000
NRG1 -8.259035 -1.373999 0.0000000 0.0000000
ROBO1 3.564108 1.348679 0.0003651 0.0015290
PTK2B 26.392380 1.342578 0.0000000 0.0000000
KCNAB1 -12.138035 -1.330926 0.0000000 0.0000000
EPHA10 18.537249 1.324246 0.0000000 0.0000000
FGF1 -5.198985 -1.281959 0.0000002 0.0000012
CNN3 -7.434592 -1.279731 0.0000000 0.0000000
SPI1 -5.233968 -1.250813 0.0000002 0.0000010
TPBG -8.112574 -1.245053 0.0000000 0.0000000
NPTX1 13.118690 1.243914 0.0000000 0.0000000
RPH3A -17.542503 -1.155773 0.0000000 0.0000000
SLC7A5 8.056058 1.115587 0.0000000 0.0000000
AUTS2 6.378199 1.113045 0.0000000 0.0000000
CPLX1 11.000213 1.104526 0.0000000 0.0000000
TF 4.439932 1.103648 0.0000090 0.0000450
TRIB2 -8.483463 -1.102840 0.0000000 0.0000000
SCN4B 5.325308 1.074588 0.0000001 0.0000006
SHARPIN 4.328613 1.052253 0.0000150 0.0000721
HMGCR 4.859656 1.045379 0.0000012 0.0000063
CD2AP 3.265693 1.043305 0.0010920 0.0043858
TSHZ1 10.969707 1.021828 0.0000000 0.0000000
CNTN2 5.291757 1.019630 0.0000001 0.0000007
BCAN 7.191358 1.018866 0.0000000 0.0000000
DEPTOR 6.141353 1.016486 0.0000000 0.0000000
BRAF 2.622218 1.013695 0.0087360 0.0310190
NTNG2 2.668266 1.010625 0.0076244 0.0276737
PTBP1 10.981189 1.003848 0.0000000 0.0000000

5.5 L5_6 EP

names scores logfoldchanges pvals pvals_adj
TPBG 4.479676 6.517034 0.0000075 0.0000796
MEIS2 3.062215 3.002218 0.0021971 0.0136273
CAMK2A 9.422451 2.280691 0.0000000 0.0000000
VIM -3.389069 -2.275746 0.0007013 0.0052066
HNRNPU 11.249299 2.146370 0.0000000 0.0000000
TTC21B 2.931866 2.124518 0.0033693 0.0203823
ADRB1 3.941905 1.959239 0.0000808 0.0007202
SHARPIN 3.464396 1.916386 0.0005314 0.0040687
GRIA3 8.086866 1.689336 0.0000000 0.0000000
ELOVL1 3.654025 1.655160 0.0002582 0.0020738
MAPK1 2.788417 1.637631 0.0052966 0.0301785
GRIK1 -3.078590 -1.560453 0.0020798 0.0132353
AUTS2 3.364506 1.542686 0.0007668 0.0056080
TSHZ1 7.431848 1.519097 0.0000000 0.0000000
HTR2C 9.998213 1.493823 0.0000000 0.0000000
ATXN1 6.511218 1.490109 0.0000000 0.0000000
SNCG 4.854675 1.479217 0.0000012 0.0000155
SCN1A 5.925304 1.382507 0.0000000 0.0000001
EPHA7 6.364494 1.360977 0.0000000 0.0000000
TSC1 6.753575 1.306347 0.0000000 0.0000000
SORL1 10.059457 1.287832 0.0000000 0.0000000
FGF1 -5.603689 -1.279657 0.0000000 0.0000004
TF 2.639727 1.276813 0.0082973 0.0451741
GRIK2 5.377052 1.256225 0.0000001 0.0000013
CNTN2 5.610239 1.228921 0.0000000 0.0000004
AXIN2 4.211773 1.174095 0.0000253 0.0002534
FGF17 7.562851 1.162276 0.0000000 0.0000000
PSEN1 4.193433 1.161168 0.0000275 0.0002693
LRPPRC 3.301297 1.156846 0.0009624 0.0067828
SPI1 -2.828373 -1.138884 0.0046785 0.0272914
LYNX1 7.424643 1.111057 0.0000000 0.0000000
SLC7A5 3.586558 1.086731 0.0003351 0.0026482
EPHA10 5.813295 1.085517 0.0000000 0.0000001
GRIN1 9.911750 1.063022 0.0000000 0.0000000
STRADA 4.542885 1.027598 0.0000055 0.0000647
NPRL3 5.071158 1.026602 0.0000004 0.0000059
PTBP1 4.663736 1.024822 0.0000031 0.0000377
ABCA2 6.008164 1.023869 0.0000000 0.0000000
SEPTIN4 5.866352 1.015338 0.0000000 0.0000001
CCDC88A 4.660461 1.013554 0.0000032 0.0000377
SCN4B 3.056319 1.011343 0.0022407 0.0137244
PCSK1 4.755439 1.008295 0.0000020 0.0000249
BIN1 9.349089 1.000018 0.0000000 0.0000000

5.6 L5_6 IT

names scores logfoldchanges pvals pvals_adj
SLCO2A1 10.410595 3.435334 0.0000000 0.0000000
NR2F2 5.004632 2.856337 0.0000006 0.0000019
CSPG4 4.019124 2.850327 0.0000584 0.0001617
PDGFRB 16.982796 2.552995 0.0000000 0.0000000
CDKN1C 4.569991 2.435692 0.0000049 0.0000147
HTR2C 3.008118 2.408424 0.0026287 0.0066395
TPBG 11.890178 2.322820 0.0000000 0.0000000
SNCG 23.163086 2.212356 0.0000000 0.0000000
VIPR2 8.447200 2.206460 0.0000000 0.0000000
TH 4.725085 2.159203 0.0000023 0.0000071
ADRB1 16.311861 2.101454 0.0000000 0.0000000
CDH7 3.423902 1.968040 0.0006173 0.0016175
CAMK2A 42.860905 1.833882 0.0000000 0.0000000
HCAR1 2.673231 1.805427 0.0075125 0.0187811
HNRNPU 36.887325 1.784152 0.0000000 0.0000000
SCN1A 22.895205 1.707630 0.0000000 0.0000000
MTOR 4.786234 1.682108 0.0000017 0.0000054
TTC21B 7.299089 1.680001 0.0000000 0.0000000
IL23R 2.580577 1.666896 0.0098635 0.0238086
CPLX1 25.992918 1.643198 0.0000000 0.0000000
PLD1 4.347667 1.637903 0.0000138 0.0000401
LYNX1 33.481060 1.636852 0.0000000 0.0000000
GLP2R 6.303179 1.624578 0.0000000 0.0000000
EPHA10 22.594664 1.587889 0.0000000 0.0000000
TRPM4 8.934297 1.561281 0.0000000 0.0000000
CD33 2.411981 1.512002 0.0158661 0.0373769
NPTX2 22.414164 1.478291 0.0000000 0.0000000
CNTN2 12.204947 1.451223 0.0000000 0.0000000
GPR63 10.143898 1.445925 0.0000000 0.0000000
OPN3 4.259973 1.437150 0.0000204 0.0000593
MRC2 3.798490 1.426292 0.0001456 0.0003898
SCN4B 12.440490 1.395617 0.0000000 0.0000000
SOX8 5.951657 1.384737 0.0000000 0.0000000
PTBP1 20.412365 1.381989 0.0000000 0.0000000
TSC1 26.527365 1.375858 0.0000000 0.0000000
RORB 19.960709 1.364512 0.0000000 0.0000000
CBLN4 9.714286 1.356233 0.0000000 0.0000000
VRK2 -3.671680 -1.329552 0.0002410 0.0006417
VTN 4.350235 1.316887 0.0000136 0.0000399
CD2AP 7.981059 1.304537 0.0000000 0.0000000
SHARPIN 8.968277 1.303022 0.0000000 0.0000000
AUTS2 9.246805 1.281358 0.0000000 0.0000000
HTR1F 5.397953 1.280986 0.0000001 0.0000002
P2RY6 8.570025 1.279070 0.0000000 0.0000000
ACTA2 4.240965 1.271985 0.0000223 0.0000638
BIN1 36.075222 1.267861 0.0000000 0.0000000
DBH 3.665385 1.265655 0.0002470 0.0006541
CAMTA1 2.639947 1.263667 0.0082919 0.0204187
NLK 3.920768 1.261089 0.0000883 0.0002403
ATXN1 23.290607 1.252844 0.0000000 0.0000000
SLC29A2 4.202113 1.251909 0.0000264 0.0000753
RIMS2 7.542774 1.221487 0.0000000 0.0000000
CHRM4 8.542943 1.208050 0.0000000 0.0000000
KCNK10 10.095057 1.194886 0.0000000 0.0000000
SLC30A3 23.336030 1.188412 0.0000000 0.0000000
GAL3ST1 3.070914 1.176864 0.0021340 0.0055036
SLC7A5 14.779365 1.176663 0.0000000 0.0000000
SLC29A1 17.970175 1.176380 0.0000000 0.0000000
PAX6 -2.665664 -1.176115 0.0076836 0.0191116
DEPTOR 8.169632 1.156931 0.0000000 0.0000000
CCDC88A 13.000751 1.146559 0.0000000 0.0000000
SEPTIN4 13.977942 1.146442 0.0000000 0.0000000
GJA1 -4.847096 -1.146289 0.0000013 0.0000040
NPRL3 19.924122 1.144258 0.0000000 0.0000000
HMGCR 9.040175 1.142314 0.0000000 0.0000000
PTK2B 24.480621 1.138645 0.0000000 0.0000000
COL11A1 4.670675 1.123917 0.0000030 0.0000092
PSEN2 17.868180 1.117887 0.0000000 0.0000000
ACE 8.473696 1.111753 0.0000000 0.0000000
NLGN1 8.407714 1.110869 0.0000000 0.0000000
NRG2 4.611455 1.109689 0.0000040 0.0000121
KREMEN1 2.302946 1.108123 0.0212819 0.0494224
SPI1 -5.928903 -1.106988 0.0000000 0.0000000
BCAN 10.769981 1.105356 0.0000000 0.0000000
ADGRA1 23.442560 1.101024 0.0000000 0.0000000
CD8A 3.009195 1.099868 0.0026194 0.0066395
NTNG2 10.450817 1.098486 0.0000000 0.0000000
MAP4K3 4.471431 1.098346 0.0000078 0.0000231
SV2A 30.480812 1.097146 0.0000000 0.0000000
DVL2 11.421903 1.094287 0.0000000 0.0000000
CUX2 9.423747 1.091285 0.0000000 0.0000000
MYD88 2.589152 1.088113 0.0096213 0.0233387
ITGA7 6.797273 1.086758 0.0000000 0.0000000
WWOX 6.221785 1.085042 0.0000000 0.0000000
CALB1 -2.526892 -1.081883 0.0115077 0.0276410
APH1B 4.771339 1.074602 0.0000018 0.0000057
MAS1 2.348298 1.066942 0.0188594 0.0440053
SULF2 8.371453 1.059383 0.0000000 0.0000000
CREBBP 25.073566 1.057401 0.0000000 0.0000000
MCAM 4.887128 1.056765 0.0000010 0.0000033
BCL11B 5.312647 1.055185 0.0000001 0.0000004
BRAF 4.358522 1.036937 0.0000131 0.0000387
SST -4.516735 -1.030561 0.0000063 0.0000188
STXBP1 22.977398 1.025401 0.0000000 0.0000000
GLDN 4.163776 1.021034 0.0000313 0.0000876
ABCA2 22.174011 1.017164 0.0000000 0.0000000
BDNF 8.140168 1.009520 0.0000000 0.0000000
NPTX1 19.083569 1.008115 0.0000000 0.0000000
AQP4 -3.798797 -1.007800 0.0001454 0.0003898
ATP1B3 5.635387 1.007236 0.0000000 0.0000001

5.7 L6b

names scores logfoldchanges pvals pvals_adj
P2RY6 8.068946 2.860214 0.0000000 0.0000000
MYD88 3.309149 2.205270 0.0009358 0.0032521
CNR1 15.558931 2.154729 0.0000000 0.0000000
GPR63 7.892134 2.050778 0.0000000 0.0000000
CAMK2A 24.542036 2.035895 0.0000000 0.0000000
VIM -3.331700 -1.972476 0.0008632 0.0030211
CELSR1 -6.357599 -1.906185 0.0000000 0.0000000
HNRNPU 21.627840 1.857511 0.0000000 0.0000000
GRM1 10.541858 1.752510 0.0000000 0.0000000
PTK2B 24.106367 1.736840 0.0000000 0.0000000
SNCG 15.178018 1.736460 0.0000000 0.0000000
ACTA2 3.247901 1.670504 0.0011626 0.0040118
LRP6 2.428248 1.632990 0.0151720 0.0453309
COCH 2.602559 1.606789 0.0092531 0.0286963
GRIK2 20.220890 1.596320 0.0000000 0.0000000
VTN 2.816532 1.566788 0.0048545 0.0157531
BIN1 25.151007 1.555723 0.0000000 0.0000000
DEPTOR 7.045016 1.546693 0.0000000 0.0000000
PDYN 6.510105 1.525550 0.0000000 0.0000000
CD2AP 6.332371 1.502378 0.0000000 0.0000000
TTC21B 3.907941 1.496992 0.0000931 0.0003649
SYT6 -14.046816 -1.493871 0.0000000 0.0000000
COL5A2 -3.530800 -1.484744 0.0004143 0.0015150
PDGFRB 2.922268 1.480307 0.0034749 0.0116624
KCNK10 6.254407 1.477474 0.0000000 0.0000000
MCAM 2.832766 1.428384 0.0046147 0.0150748
NPTX1 15.715957 1.420482 0.0000000 0.0000000
MEIS2 2.964256 1.390473 0.0030342 0.0102534
SLC7A5 10.233511 1.344307 0.0000000 0.0000000
CNTN2 8.660630 1.325183 0.0000000 0.0000000
SCN4B 7.164967 1.307029 0.0000000 0.0000000
CCDC88A 10.633291 1.304885 0.0000000 0.0000000
AUTS2 5.327789 1.300507 0.0000001 0.0000005
ADRB1 4.433463 1.299040 0.0000093 0.0000395
TRPM4 5.092625 1.293271 0.0000004 0.0000017
NPRL3 14.563695 1.291636 0.0000000 0.0000000
NPY 4.462420 1.285273 0.0000081 0.0000355
LYNX1 16.810656 1.277958 0.0000000 0.0000000
ERBB4 2.730627 1.250193 0.0063214 0.0202450
SCN1A 4.966005 1.245916 0.0000007 0.0000032
FZD7 2.516610 1.225912 0.0118490 0.0356197
PTBP1 12.231531 1.214391 0.0000000 0.0000000
SST -3.408918 -1.213942 0.0006522 0.0023529
CARS2 7.315016 1.197728 0.0000000 0.0000000
WWOX 5.796977 1.188581 0.0000000 0.0000000
TSC1 14.545970 1.174477 0.0000000 0.0000000
MAPK1 7.159527 1.165524 0.0000000 0.0000000
KCNH7 4.476723 1.163863 0.0000076 0.0000338
ATXN1 13.774666 1.132399 0.0000000 0.0000000
APH1B 2.877517 1.118879 0.0040082 0.0132703
AXIN1 4.714476 1.104991 0.0000024 0.0000110
SHARPIN 4.447590 1.101642 0.0000087 0.0000377
NPTXR 2.677452 1.093653 0.0074185 0.0233016
HRH3 2.541969 1.092442 0.0110230 0.0333412
GRIN1 21.954920 1.068489 0.0000000 0.0000000
NPRL2 5.674262 1.068282 0.0000000 0.0000001
GJA1 -2.909896 -1.023006 0.0036155 0.0120516
PLAGL1 -5.441072 -1.011868 0.0000001 0.0000003
GRIK3 16.483795 1.010827 0.0000000 0.0000000

5.8 LAMP5

names scores logfoldchanges pvals pvals_adj
MYH11 3.511338 2.447084 0.0004459 0.0030770
SLC7A5 5.250301 1.742117 0.0000002 0.0000019
SLC32A1 9.919564 1.629782 0.0000000 0.0000000
ARX 8.902006 1.611289 0.0000000 0.0000000
CAMK2A 6.325984 1.603026 0.0000000 0.0000000
HNRNPU 9.385974 1.569362 0.0000000 0.0000000
BIN1 12.405436 1.514403 0.0000000 0.0000000
HRH3 3.987398 1.511400 0.0000668 0.0005644
PSEN1 3.852172 1.377294 0.0001171 0.0009253
PRSS12 6.169999 1.355876 0.0000000 0.0000000
AUTS2 2.671907 1.299737 0.0075422 0.0429728
ATXN1 7.179847 1.254965 0.0000000 0.0000000
SOX1 9.860453 1.254847 0.0000000 0.0000000
PTBP1 5.704021 1.252816 0.0000000 0.0000002
DVL1 3.639052 1.213689 0.0002736 0.0020044
CRTAC1 9.435596 1.205946 0.0000000 0.0000000
WFS1 2.684955 1.187972 0.0072540 0.0418170
KCND2 4.848379 1.185695 0.0000012 0.0000127
SCN4B 3.114753 1.171632 0.0018410 0.0121903
TSC1 5.068023 1.124374 0.0000004 0.0000045
CREBBP 7.341170 1.109764 0.0000000 0.0000000
PROX1 6.547605 1.104067 0.0000000 0.0000000
EPHA10 5.018598 1.102136 0.0000005 0.0000057
AXIN2 5.098864 1.068605 0.0000003 0.0000040
CNTN2 2.639484 1.065956 0.0083032 0.0462339
DVL2 2.928718 1.050442 0.0034036 0.0208472
NRG2 2.618132 1.044162 0.0088413 0.0481357
ADGRA1 5.224798 1.024789 0.0000002 0.0000021
NPTXR 8.382255 1.021782 0.0000000 0.0000000
WWOX 2.826903 1.013781 0.0047001 0.0274170
CNTNAP2 3.420396 1.011842 0.0006253 0.0042555

5.9 Microglia

names scores logfoldchanges pvals pvals_adj
GLDN 30.439344 2.929219 0.0000000 0.0000000
AQP1 -5.665077 -2.288814 0.0000000 0.0000002
P2RY6 6.397656 1.861073 0.0000000 0.0000000
SYT6 27.299498 1.856111 0.0000000 0.0000000
FZD8 5.799194 1.637917 0.0000000 0.0000001
SGK1 10.131671 1.521562 0.0000000 0.0000000
LYNX1 7.606777 1.488630 0.0000000 0.0000000
PROX1 2.681550 1.453019 0.0073282 0.0427478
ITGAL 10.171062 1.348232 0.0000000 0.0000000
CNN3 -3.452082 -1.338217 0.0005563 0.0039504
CD9 3.754943 1.309089 0.0001734 0.0013274
CDH7 2.919146 1.287224 0.0035099 0.0220495
BIN1 33.703068 1.265856 0.0000000 0.0000000
ABI3 18.379566 1.223599 0.0000000 0.0000000
VIM -6.148516 -1.222129 0.0000000 0.0000000
PRKCD 30.867922 1.199568 0.0000000 0.0000000
CAMK2A 5.309079 1.180943 0.0000001 0.0000012
SHARPIN 4.895581 1.162551 0.0000010 0.0000100
CD74 47.594425 1.131279 0.0000000 0.0000000
HLA-DMB 10.392750 1.106488 0.0000000 0.0000000
ITGAX 18.996319 1.078943 0.0000000 0.0000000
PTK2B 11.467946 1.072551 0.0000000 0.0000000
SNCG 3.554549 1.049079 0.0003786 0.0027691
HNRNPU 15.395666 1.048965 0.0000000 0.0000000
GJA1 -3.707510 -1.047797 0.0002093 0.0015779
FOS 7.167586 1.044725 0.0000000 0.0000000
CCDC88A 3.896343 1.032750 0.0000977 0.0008110

5.10 Oligo

names scores logfoldchanges pvals pvals_adj
CNTNAP2 15.281305 2.776823 0.0000000 0.0000000
COL5A2 3.309412 2.432704 0.0009349 0.0031594
SLC6A4 2.400795 2.427331 0.0163595 0.0474328
AQP1 -7.024278 -2.381509 0.0000000 0.0000000
HCAR1 11.340734 1.990419 0.0000000 0.0000000
FEV 2.391587 1.972657 0.0167757 0.0482612
RORB 3.952593 1.864031 0.0000773 0.0002983
ITGAL 3.905765 1.835215 0.0000939 0.0003540
ADAM10 4.891583 1.828156 0.0000010 0.0000041
NPTX2 21.617764 1.802396 0.0000000 0.0000000
LYNX1 14.508653 1.727815 0.0000000 0.0000000
CA12 3.338649 1.592332 0.0008419 0.0028647
CCDC88A 28.526630 1.586814 0.0000000 0.0000000
ASPA 24.588646 1.581868 0.0000000 0.0000000
MYD88 10.396500 1.579536 0.0000000 0.0000000
MTOR 8.334654 1.573572 0.0000000 0.0000000
SOX8 30.710909 1.572615 0.0000000 0.0000000
OPN3 2.579884 1.567869 0.0098834 0.0304582
BIN1 84.638084 1.554145 0.0000000 0.0000000
HNRNPU 48.749060 1.536946 0.0000000 0.0000000
GNAO1 59.408400 1.523214 0.0000000 0.0000000
HEATR3 4.536619 1.521943 0.0000057 0.0000230
SH3TC2 35.030590 1.511758 0.0000000 0.0000000
TLX3 9.681120 1.510498 0.0000000 0.0000000
GABRA2 3.344508 1.491753 0.0008243 0.0028245
CTNNA3 6.061849 1.474033 0.0000000 0.0000000
NKX6-2 50.278400 1.466298 0.0000000 0.0000000
CELSR1 2.410829 1.461592 0.0159163 0.0464825
ATXN1 23.858448 1.402903 0.0000000 0.0000000
SLC7A5 2.427341 1.398681 0.0152099 0.0448968
SHARPIN 10.757661 1.389932 0.0000000 0.0000000
NNAT -9.329770 -1.389263 0.0000000 0.0000000
MCAM 39.094680 1.375171 0.0000000 0.0000000
GPR37 57.621075 1.369954 0.0000000 0.0000000
FEZF2 6.598865 1.354547 0.0000000 0.0000000
PENK 2.908237 1.352366 0.0036347 0.0117172
VWF 3.624429 1.346955 0.0002896 0.0010511
NPRL2 6.134121 1.337012 0.0000000 0.0000000
AUTS2 7.173422 1.336315 0.0000000 0.0000000
TSC1 17.451557 1.312108 0.0000000 0.0000000
VIM -7.802017 -1.305293 0.0000000 0.0000000
LRATD2 15.479521 1.298438 0.0000000 0.0000000
STRADA 19.560616 1.286361 0.0000000 0.0000000
BRAF 2.614931 1.283622 0.0089245 0.0278537
UGT8 19.743390 1.280418 0.0000000 0.0000000
DVL2 9.348951 1.269356 0.0000000 0.0000000
GJA1 -3.254996 -1.259461 0.0011339 0.0038057
NLK 2.410359 1.252498 0.0159368 0.0464825
ABCA8 8.678375 1.242546 0.0000000 0.0000000
GLP2R 3.355605 1.237979 0.0007919 0.0027327
DEPDC5 6.292041 1.230706 0.0000000 0.0000000
ATF3 3.601024 1.202455 0.0003170 0.0011337
NPRL3 20.396082 1.201350 0.0000000 0.0000000
GLDN 44.095980 1.186834 0.0000000 0.0000000
LRPPRC 11.199956 1.166144 0.0000000 0.0000000
CDKN1C 16.267717 1.155649 0.0000000 0.0000000
SGK2 29.211126 1.155097 0.0000000 0.0000000
IYD 2.892514 1.139250 0.0038217 0.0122395
UBE3A 6.019587 1.122264 0.0000000 0.0000000
ADARB2 4.018627 1.114598 0.0000585 0.0002276
NTNG2 8.072918 1.113271 0.0000000 0.0000000
FGF17 3.030422 1.108796 0.0024421 0.0080311
PROX1 29.546194 1.099592 0.0000000 0.0000000
GAL3ST1 23.456837 1.067722 0.0000000 0.0000000
CREBBP 25.381382 1.058965 0.0000000 0.0000000
PTBP1 14.876349 1.056821 0.0000000 0.0000000
IQCK 2.464366 1.051507 0.0137256 0.0407608
SEPTIN4 62.515045 1.048643 0.0000000 0.0000000
ABCA2 72.062584 1.034177 0.0000000 0.0000000
FGFR2 17.617070 1.027375 0.0000000 0.0000000
GRIA3 12.975366 1.025808 0.0000000 0.0000000
CARS2 6.638287 1.004991 0.0000000 0.0000000
CNTN2 53.661366 1.002197 0.0000000 0.0000000

5.11 OPC

names scores logfoldchanges pvals pvals_adj
PKP2 4.164984 3.410221 0.0000311 0.0001557
SLC29A2 3.783197 2.503206 0.0001548 0.0007295
FGFR3 30.581114 2.426141 0.0000000 0.0000000
VIPR2 9.240804 1.871083 0.0000000 0.0000000
TMEM119 2.981366 1.813700 0.0028697 0.0116209
ALDH1L1 14.837585 1.796104 0.0000000 0.0000000
AQP1 -2.569453 -1.793283 0.0101859 0.0381000
GRIK1 12.173743 1.724291 0.0000000 0.0000000
ADARB2 12.833031 1.606173 0.0000000 0.0000000
CUX2 7.295879 1.603415 0.0000000 0.0000000
NKX6-2 2.481494 1.594579 0.0130833 0.0474875
HNRNPU 20.726475 1.566395 0.0000000 0.0000000
CAMK2A 7.136366 1.563443 0.0000000 0.0000000
GPNMB 9.998622 1.553628 0.0000000 0.0000000
SOX8 21.996546 1.507017 0.0000000 0.0000000
LMNA 6.339156 1.505167 0.0000000 0.0000000
WWOX 8.829294 1.497661 0.0000000 0.0000000
NPTX2 6.047966 1.483324 0.0000000 0.0000000
NKD1 12.445533 1.464491 0.0000000 0.0000000
APH1B 2.996059 1.411688 0.0027349 0.0112615
CACNG5 9.775554 1.377264 0.0000000 0.0000000
LYNX1 5.394662 1.356847 0.0000001 0.0000004
BMP2 3.538122 1.312143 0.0004030 0.0018116
NLGN1 8.151117 1.296422 0.0000000 0.0000000
NTNG2 4.244844 1.296320 0.0000219 0.0001128
TRPM4 4.805993 1.294735 0.0000015 0.0000088
PROX1 6.516120 1.293908 0.0000000 0.0000000
SLC7A5 8.189898 1.270768 0.0000000 0.0000000
CSF1 6.992896 1.253651 0.0000000 0.0000000
SULF2 24.360653 1.243613 0.0000000 0.0000000
SNCG 4.268965 1.239784 0.0000196 0.0001024
ARX 3.015699 1.230728 0.0025639 0.0106466
DVL2 5.903646 1.217599 0.0000000 0.0000000
CARS2 3.996957 1.194618 0.0000642 0.0003113
NPRL3 10.087758 1.192805 0.0000000 0.0000000
BCL11B 2.938487 1.189006 0.0032982 0.0131391
STRADA 6.685596 1.170416 0.0000000 0.0000000
ABCA2 13.193280 1.170225 0.0000000 0.0000000
SHARPIN 4.212810 1.170221 0.0000252 0.0001287
PDGFRB 4.620625 1.163655 0.0000038 0.0000215
BIN1 10.443604 1.154760 0.0000000 0.0000000
TSC1 9.246831 1.149806 0.0000000 0.0000000
CCDC88A 7.964824 1.130471 0.0000000 0.0000000
CERS2 4.467684 1.115009 0.0000079 0.0000435
MRC2 3.617481 1.094000 0.0002975 0.0013623
WFS1 4.811595 1.091535 0.0000015 0.0000086
CSPG4 18.458359 1.090449 0.0000000 0.0000000
PTK2B 4.136983 1.081665 0.0000352 0.0001742
FOS -2.663875 -1.067430 0.0077246 0.0291159
MINK1 13.285097 1.056108 0.0000000 0.0000000
UBE3A 4.181475 1.042963 0.0000290 0.0001463
SCN3A 4.102224 1.037438 0.0000409 0.0002005
NPRL2 2.966401 1.037052 0.0030131 0.0121017
PNKP 7.212281 1.036582 0.0000000 0.0000000
KCND2 15.873483 1.024971 0.0000000 0.0000000
DVL1 5.552988 1.023846 0.0000000 0.0000002
FGF17 2.529692 1.021836 0.0114163 0.0423786
SGK2 4.418778 1.008715 0.0000099 0.0000540
CREBBP 15.908209 1.002284 0.0000000 0.0000000

5.12 Pvalb

names scores logfoldchanges pvals pvals_adj
HNRNPU 14.886833 1.780629 0.0000000 0.0000000
CAMK2A 11.383479 1.747443 0.0000000 0.0000000
CUX2 5.589731 1.741023 0.0000000 0.0000002
CHRM4 3.292930 1.622334 0.0009915 0.0051684
HRH3 7.601695 1.595679 0.0000000 0.0000000
SLC7A5 5.937768 1.525205 0.0000000 0.0000000
ARX 15.431036 1.485043 0.0000000 0.0000000
SLC32A1 14.655663 1.475100 0.0000000 0.0000000
TRPM4 7.073513 1.406396 0.0000000 0.0000000
BIN1 16.840322 1.386398 0.0000000 0.0000000
CNTN2 8.541594 1.381161 0.0000000 0.0000000
CX3CL1 12.559114 1.345329 0.0000000 0.0000000
SPI1 -2.945935 -1.320673 0.0032198 0.0153175
SOX1 4.754924 1.313804 0.0000020 0.0000133
TSC1 10.695335 1.290170 0.0000000 0.0000000
DEPTOR 6.936541 1.284847 0.0000000 0.0000000
CCDC88A 7.589760 1.273870 0.0000000 0.0000000
TSHZ1 3.246793 1.255962 0.0011671 0.0060200
PTBP1 7.363556 1.254278 0.0000000 0.0000000
GRIK3 10.609628 1.242816 0.0000000 0.0000000
ELOVL1 2.968523 1.233655 0.0029923 0.0145173
ATXN1 9.224210 1.233415 0.0000000 0.0000000
CNTNAP2 9.687912 1.233205 0.0000000 0.0000000
CACNG5 -4.628686 -1.233178 0.0000037 0.0000244
BCL11B 9.135539 1.223616 0.0000000 0.0000000
SST -6.079306 -1.204668 0.0000000 0.0000000
LYNX1 12.444489 1.201154 0.0000000 0.0000000
CARS2 4.130141 1.179024 0.0000363 0.0002193
DVL2 3.743896 1.153052 0.0001812 0.0010445
SCN2A 10.016885 1.149163 0.0000000 0.0000000
CD2AP 3.064163 1.140629 0.0021828 0.0111414
TTC21B 2.651646 1.123544 0.0080100 0.0344291
LMNA 2.669108 1.097951 0.0076053 0.0332732
CREBBP 10.950055 1.096961 0.0000000 0.0000000
UBE3A 2.731826 1.084312 0.0062984 0.0285762
MINK1 11.154952 1.058033 0.0000000 0.0000000
SEPTIN4 11.552891 1.048314 0.0000000 0.0000000

5.13 Sst

names scores logfoldchanges pvals pvals_adj
SLC7A5 6.873033 2.043587 0.0000000 0.0000000
LEF1 -3.216001 -1.990818 0.0012999 0.0064995
HRH3 4.175110 1.896554 0.0000298 0.0001714
HNRNPU 15.852629 1.814596 0.0000000 0.0000000
CAMK2A 13.714177 1.790811 0.0000000 0.0000000
CUX2 6.007900 1.660048 0.0000000 0.0000000
NLGN1 3.508728 1.640646 0.0004503 0.0023723
PTK2B 7.655380 1.633149 0.0000000 0.0000000
SHARPIN 4.021857 1.584150 0.0000577 0.0003215
DEPTOR 4.193725 1.522320 0.0000274 0.0001601
AUTS2 6.084611 1.515317 0.0000000 0.0000000
ARX 17.285275 1.509545 0.0000000 0.0000000
BIN1 17.537565 1.506816 0.0000000 0.0000000
CRH -3.086031 -1.501002 0.0020285 0.0098411
KCNK10 3.090306 1.478891 0.0019995 0.0097976
CNTNAP2 9.826845 1.459725 0.0000000 0.0000000
SPI1 -4.594038 -1.442977 0.0000043 0.0000284
CHRM4 2.522286 1.440377 0.0116595 0.0488303
GRIN1 19.838436 1.421362 0.0000000 0.0000000
GRIK3 17.080000 1.412500 0.0000000 0.0000000
CX3CL1 11.254035 1.412221 0.0000000 0.0000000
ELOVL1 3.615133 1.408351 0.0003002 0.0015989
SLC32A1 12.640902 1.370342 0.0000000 0.0000000
EPHA7 4.348046 1.357216 0.0000137 0.0000852
GRIK1 15.761408 1.297131 0.0000000 0.0000000
CCDC88A 6.198889 1.266475 0.0000000 0.0000000
BCL11A 3.790825 1.250928 0.0001501 0.0008085
RIMS2 2.963429 1.247363 0.0030423 0.0138031
CREBBP 11.482142 1.246653 0.0000000 0.0000000
APP 19.787258 1.236912 0.0000000 0.0000000
LYNX1 8.402578 1.228512 0.0000000 0.0000000
ATXN1 8.431824 1.228170 0.0000000 0.0000000
CNTN2 5.804200 1.212192 0.0000000 0.0000001
SOX1 4.172804 1.203608 0.0000301 0.0001714
FGF17 9.366524 1.186327 0.0000000 0.0000000
DLX1 10.089877 1.181282 0.0000000 0.0000000
SYP 17.780577 1.180847 0.0000000 0.0000000
CARS2 3.111677 1.178655 0.0018603 0.0092075
CDH12 2.752981 1.175493 0.0059055 0.0260695
AXIN1 2.710408 1.172627 0.0067201 0.0291401
PTBP1 6.494371 1.131867 0.0000000 0.0000000
TSC1 8.411634 1.129972 0.0000000 0.0000000
SV2A 14.856964 1.083677 0.0000000 0.0000000
DVL2 3.384720 1.067767 0.0007125 0.0036751
NPAS1 5.560571 1.065917 0.0000000 0.0000002
CAMK2G 14.399287 1.059743 0.0000000 0.0000000
CERS2 2.703828 1.045007 0.0068546 0.0294627
SLC29A1 8.187968 1.044445 0.0000000 0.0000000
GRIN3A 10.541818 1.030304 0.0000000 0.0000000
DVL1 3.862699 1.029057 0.0001121 0.0006105
SST -11.355604 -1.028781 0.0000000 0.0000000
ELFN1 9.039492 1.015921 0.0000000 0.0000000
SCN1A 6.720567 1.009213 0.0000000 0.0000000
EPHA10 5.449779 1.002795 0.0000001 0.0000004

5.14 Vip

names scores logfoldchanges pvals pvals_adj
GRIK3 2.610889 2.773168 0.0090307 0.0402278
DRD2 2.841829 2.155215 0.0044856 0.0222012
PDGFRB 2.787451 2.063661 0.0053125 0.0257733
TBX1 2.715416 1.848518 0.0066192 0.0311868
TRPM4 2.634628 1.797993 0.0084229 0.0378646
SLC7A5 6.608975 1.765761 0.0000000 0.0000000
GRIK1 4.575028 1.731581 0.0000048 0.0000343
NR2F2 7.369229 1.718081 0.0000000 0.0000000
COL11A1 4.427398 1.698495 0.0000095 0.0000677
SLC29A2 2.680178 1.658774 0.0073583 0.0340148
HNRNPU 12.992722 1.653592 0.0000000 0.0000000
NTNG2 2.644940 1.644093 0.0081705 0.0371921
GRIA3 6.139009 1.532503 0.0000000 0.0000000
SLC32A1 11.660349 1.532150 0.0000000 0.0000000
CAMK2A 10.808401 1.521598 0.0000000 0.0000000
BIN1 16.406893 1.477015 0.0000000 0.0000000
CNTNAP2 9.650512 1.475085 0.0000000 0.0000000
ARX 7.381321 1.471068 0.0000000 0.0000000
ELFN1 9.025350 1.363362 0.0000000 0.0000000
ATXN1 9.300058 1.330980 0.0000000 0.0000000
HRH3 7.697501 1.316363 0.0000000 0.0000000
CX3CL1 8.637135 1.315418 0.0000000 0.0000000
LYNX1 8.070506 1.301527 0.0000000 0.0000000
DEPDC5 3.547112 1.301010 0.0003895 0.0023561
TSC1 8.253893 1.296689 0.0000000 0.0000000
GRIN3A 2.716529 1.294415 0.0065970 0.0311868
SLC29A1 8.564212 1.271067 0.0000000 0.0000000
SHARPIN 3.191762 1.253299 0.0014141 0.0077854
WFS1 5.618968 1.242105 0.0000000 0.0000002
ITGA7 7.766419 1.241740 0.0000000 0.0000000
BCAN 7.847652 1.220194 0.0000000 0.0000000
STK11 4.881637 1.215757 0.0000011 0.0000082
DVL1 5.147444 1.215398 0.0000003 0.0000021
ACE 2.900065 1.209626 0.0037309 0.0188466
CERS2 2.643827 1.175626 0.0081974 0.0371921
TSC2 8.001291 1.170989 0.0000000 0.0000000
CCDC88A 5.686848 1.157568 0.0000000 0.0000001
GRIN2A 7.755365 1.154167 0.0000000 0.0000000
ADARB2 13.018242 1.135172 0.0000000 0.0000000
CPLX1 5.964821 1.119086 0.0000000 0.0000000
AXIN1 2.799469 1.109124 0.0051187 0.0250815
SYP 16.037819 1.097143 0.0000000 0.0000000
PKP2 3.274183 1.091652 0.0010597 0.0059005
SNCG 3.164314 1.079220 0.0015545 0.0083703
CARS2 3.008079 1.077396 0.0026290 0.0137046
APP 15.913633 1.056322 0.0000000 0.0000000
CREBBP 9.228395 1.052622 0.0000000 0.0000000
VIPR2 2.695906 1.052364 0.0070198 0.0327589
SCN1A 5.234018 1.040032 0.0000002 0.0000014
SULF2 3.815070 1.029665 0.0001361 0.0008444
NPTX2 3.280934 1.028063 0.0010346 0.0058642
AXIN2 5.506428 1.022153 0.0000000 0.0000003
PTBP1 5.333353 1.003501 0.0000001 0.0000008

5.15 VLMC

names scores logfoldchanges pvals pvals_adj
ANPEP 6.780589 1.854619 0.0000000 0.0000000
SHARPIN 3.474677 1.784888 0.0005115 0.0073712
FOS -8.280366 -1.713197 0.0000000 0.0000000
IGF2 19.030077 1.648086 0.0000000 0.0000000
NKD1 8.401329 1.615173 0.0000000 0.0000000
HNRNPU 12.079896 1.604471 0.0000000 0.0000000
CSPG4 6.954158 1.587315 0.0000000 0.0000000
AQP1 -2.904190 -1.527950 0.0036821 0.0440050
SLC7A11 3.666023 1.464087 0.0002464 0.0036580
SLC7A5 6.977059 1.459799 0.0000000 0.0000000
SLC6A13 14.581616 1.413753 0.0000000 0.0000000
NOSTRIN 3.077412 1.332369 0.0020881 0.0262346
AXIN2 7.274607 1.226050 0.0000000 0.0000000
COL5A2 3.696717 1.206754 0.0002184 0.0033443
TRPM4 4.362330 1.108885 0.0000129 0.0002335
PDGFRB 18.055786 1.039298 0.0000000 0.0000000
SEPTIN4 7.564735 1.029983 0.0000000 0.0000000
TRIB2 9.003632 1.024629 0.0000000 0.0000000
TSC2 4.267044 1.013327 0.0000198 0.0003466
CREBBP 7.933281 1.008015 0.0000000 0.0000000

8. Gene Enrichment Analysis (Age)

With the differential gene list obtained from the differentiation analysis, we can assign genes to a set of predefined bins based on their functional characteristics. We utilize two primary databases for this analysis: the Gene Ontology (GO) database and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.

The GO database, established by the GO organization in 2000, provides a structured framework for biological classification. For the GO analysis, we represent the results using bar plots to indicate the count of genes enriched in various categories. Biological ontology is divided into three aspects: cellular components, molecular functions, and biological processes. Additionally, for biological processes, we use a tree plot to perform hierarchical clustering of the enriched pathways.

KEGG database offers systematic analysis of gene functions and genomic information, integrating data across genomic, biochemical, and phylogenetic dimensions. In the KEGG analysis, we employ a dot plot to display the pathways and the genes enriched in each pathway. The Gene Ratio represents the ratio of enriched genes to the total number of genes in the differential expression list, while color coding indicates the p-value associated with each pathway.

8.1 all

8.2 Astrocyte

8.3 Endothelial

8.4 L2_3_4 IT

8.5 L5_6 IT

8.6 L5_6 NP

8.7 L6b

8.8 Lamp5

8.9 Microglia

8.10 Oligo

8.11 OPC

8.12 Pvalb

8.13 Sst

8.14 Vip

8.15 VLMC

9. Gene Enrichment Analysis (Region)

8.1 all

8.2 Astrocytes

8.3 Endothelial

8.4 L2_3_4 IT

8.5 L5_6 EP

8.6 L5_6 IT

8.7 L6b

8.8 LAMP5

8.9 Microglia

8.10 Oligo

8.11 OPC

8.12 Pvalb

8.13 Sst

8.14 Vip

8.15 VLMC

Supplement 2: Abbreviation

Cell types & Regions

Astro, Astrocyte;

ABC, arachnoid barrier cells;

BAM, border-associated macrophages;

BLA, Basolateral amygdala;

CB, cerebellum;

CGE, caudal ganglionic eminence;

CHOR, choroid plexus;

CNU, cerebral nuclei;

CR, Cajal–Retzius;

CT, corticothalamic;

CTX, cerebral cortex;

CTXsp, cortical subplate;

DC, dendritic cells;

DCO, dorsal cochlear nucleus;

DG, dentate gyrus;

EA, extended amygdala;

Endo, endothelial cells;

ENT, Entorhinal area;

ENTl, Entorhinal area, lateral part;

Epen, ependymal;

EPI, epithalamus;

ET, extratelencephalic;

GC, granule cell;

HB, hindbrain;

HPF, hippocampal formation;

HY, hypothalamus;

HYa, anterior hypothalamic;

IMN, immature neurons;

IT, intratelencephalic;

L6b, layer 6b;

LGE, lateral ganglionic eminence;

LH, lateral habenula;

LSX, lateral septal complex;

MB, midbrain;

MGE, medial ganglionic eminence;

MH, medial habenula;

MM, medial mammillary nucleus;

MY, medulla;

NN, non-neuronal;

NP, near-projecting;

NT, non-telencephalon;

OB, olfactory bulb;

OEC, olfactory ensheathing cells;

OLF, olfactory areas;

Oligo, oligodendrocytes;

OPC, oligodendrocyte precursor cells;

P, pons;

PAL, pallidum;

Peri, pericytes;

PIR, piriform cortex;

SMC, smooth muscle cells;

STR, striatum;

TE, telencephalon;

TH, thalamus;

UBC, unipolar brush cells;

VLMC, vascular leptomeningeal cells.

Neurotransmitter types

Chol, cholinergic;

Dopa, dopaminergic;

GABA, GABAergic;

Glut, glutamatergic;

Glyc, glycinergic;

Hist, histaminergic;

Nora, noradrenergic;

Sero, serotonergic

ADP, anterodorsal preoptic nucleus

AHN, anterior hypothalamic nucleus

ARH, arcuate hypothalamic nucleus

CLI, central linear nucleus raphe

CUN, cuneiform nucleus

DMH, dorsomedial nucleus of the hypothalamus

DMX, dorsal motor nucleus of the vagus nerve

IF, interfascicular nucleus raphe

LHA, lateral hypothalamic area

MDRN, medullary reticular nucleus

MPN, medial preoptic nucleus

MPO, medial preoptic area

MV, medial vestibular nucleus

NTS, nucleus of the solitary tract

PAG, periaqueductal grey

PARN, parvicellular reticular nucleus

PB, parabrachial nucleus

PBG, parabigeminal nucleus

PGRN, paragigantocellular reticular nucleus

PGRNd, paragigantocellular reticular nucleus, dorsal part

PH, posterior hypothalamic nucleus

PMv, ventral premammillary nucleus

PPN, pedunculopontine nucleus

PVa, periventricular hypothalamic nucleus, anterior part

PVHd, paraventricular hypothalamic nucleus, descending division

PVi, periventricular hypothalamic nucleus, intermediate part

PVpo, periventricular hypothalamic nucleus, preoptic part

PVR, periventricular region

RAmb, midbrain raphe nuclei

RL, rostral linear nucleus raphe

SBPV, subparaventricular zone

SNc, substantia nigra, compact part

SPIV, spinal vestibular nucleus

TMv, tuberomammillary nucleus, ventral part

VII, facial motor nucleus

VMPO, ventromedial preoptic nucleus

VTA, ventral tegmental area

ZI, zona incerta.